ID F0XU78_GROCL Unreviewed; 1287 AA.
AC F0XU78;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=DNA excision repair protein rad2 {ECO:0000313|EMBL:EFW98861.1};
GN ORFNames=CMQ_4713 {ECO:0000313|EMBL:EFW98861.1};
OS Grosmannia clavigera (strain kw1407 / UAMH 11150) (Blue stain fungus)
OS (Graphiocladiella clavigera).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Leptographium.
OX NCBI_TaxID=655863 {ECO:0000313|Proteomes:UP000007796};
RN [1] {ECO:0000313|EMBL:EFW98861.1, ECO:0000313|Proteomes:UP000007796}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=kw1407 / UAMH 11150 {ECO:0000313|Proteomes:UP000007796};
RX PubMed=21262841; DOI=10.1073/pnas.1011289108;
RA DiGuistini S., Wang Y., Liao N.Y., Taylor G., Tanguay P., Feau N.,
RA Henrissat B., Chan S.K., Hesse-Orce U., Alamouti S.M., Tsui C.K.M.,
RA Docking R.T., Levasseur A., Haridas S., Robertson G., Birol I., Holt R.A.,
RA Marra M.A., Hamelin R.C., Hirst M., Jones S.J.M., Bohlmann J., Breuil C.;
RT "Genome and transcriptome analyses of the mountain pine beetle-fungal
RT symbiont Grosmannia clavigera, a lodgepole pine pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:2504-2509(2011).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
CC {ECO:0000256|ARBA:ARBA00005283}.
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DR EMBL; GL630006; EFW98861.1; -; Genomic_DNA.
DR RefSeq; XP_014168344.1; XM_014312869.1.
DR STRING; 655863.F0XU78; -.
DR GeneID; 25977955; -.
DR eggNOG; KOG2520; Eukaryota.
DR HOGENOM; CLU_003018_0_1_1; -.
DR InParanoid; F0XU78; -.
DR OrthoDB; 5479162at2759; -.
DR Proteomes; UP000007796; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd09904; H3TH_XPG; 1.
DR CDD; cd09868; PIN_XPG_RAD2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR001044; XPG/Rad2_eukaryotes.
DR InterPro; IPR019974; XPG_CS.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR16171:SF7; DNA EXCISION REPAIR PROTEIN ERCC-5; 1.
DR PANTHER; PTHR16171; DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR PRINTS; PR00066; XRODRMPGMNTG.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00842; XPG_2; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007796}.
FT DOMAIN 1..98
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 915..984
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 120..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1260
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1261..1278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1287 AA; 141765 MW; F11DE73D4E69232E CRC64;
MGVNGLWQVL QPCARPTNLA TLNRKRLAVD ASIWIYQFLK AVRDKEGNAL RNSHVVGFFR
RVCKLLWFGI LPVFVFDGGA PALKRSTLQA RRQRREGRRE DAVRTAGKLL AVQMQRIAEE
DAEKRRKRRR EAPSESAPSA VEASGEDGMV DGEMLPSMDK VVYAEEMHKP EQERLQARKF
TKKDAYHLPE LDRPIEGMGR PEDPRIMNID ELEEYARQFH AGEDINLYDF SKIDFDGDFF
KSLPPADRYY ILNAARIRSR LRMGLSKEQL DVMFPDRMAF SRFQIERVRE RNHLTQRLMI
EAGMTGIDLT MGVNGRVAGE KDREYILVKN EGVEGGWALG VVSRDKEQGQ VHKPIDVDAL
QFQYDGGKGE DSEDDVEFQD VPIEGLNRLP KLSVSQKDDQ TAGGHEADAE DESLFVSSYQ
PVETLQPETM QEAVGDENLV ADEEEDLHKA IAMSLRNQHD ADASGGDIDE DEDETFEDVD
IPAPEWTQKA AEVVSRPIVA TSGRMVAHIV NNRSNAAISA SKAQGSKDDD NSDSSDSELD
IRAAMVAAAK KKKRTVEQGT SQAGSVQSAD PPKSRVKPLF DGPLPFEQLD WKTSIFEKKP
NADAASSFAA LASASTVQDG KAAAAAAETG SLEADSDDDG LAGGFVIEAD EANSATGDVD
DDMAGADRET GVKDDAPRPL PPWMADATDI RTAIRQQQAY DDGINAEDRE MALAEERTWQ
RQQEPQIVEI GSSSDSGSDI EIIEAPRLAR ESETVEQLTR VAETNTAEDQ QEPTAVTDSI
SEAVEMVEPA VTRLSSPEME FEDVELPDRP TVTKEVVAEA VTGIAPVDDD GLFTGEGEDE
FDISDPEEEE LFAQMAEEAE EHARFASTLN HKTGRESQAV FEQEVKALRN QQKKDRRDAD
EVTMVMVSEC QALLRLFGIP YITAPMEAEA QCSELVSLGL VDGIVTDDSD TFLFGGTRVY
KNMFNGNKFV ECFLAADLEK EMSLSREKLI SLAQLLGSDY TDGLPGVGPV TAMEILSEFP
GPQGLEEFRT WWDDVQMHGR SREADAGSPF RRKFRKSQGT KLFLPTGFPN AAVAAAYKKP
EVDSSTEPFQ WGVPDLDGLR SFLMSTIGWS QDRTDEVLVP VIRDMNRREA EGTQSNITRF
FSGAVGSGAR LTAAQQRAQA QAQAQMPDEF APRHAPRNKS SRGSSRRLAA AVSNLKAGTT
SMEAAAAIMR SGPVVRAPSR KKTTAAGRKR KPEASPTVTG SGEPETSANE DDEDSAAELD
NDKDEPAGRL SGRQQRATRR GEKRVKA
//
