ID F0Y4D8_AURAN Unreviewed; 2439 AA.
AC F0Y4D8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN ORFNames=AURANDRAFT_71169 {ECO:0000313|EMBL:EGB10105.1};
OS Aureococcus anophagefferens (Harmful bloom alga).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Pelagophyceae; Pelagomonadales;
OC Aureococcus.
OX NCBI_TaxID=44056 {ECO:0000313|Proteomes:UP000002729};
RN [1] {ECO:0000313|EMBL:EGB10105.1, ECO:0000313|Proteomes:UP000002729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP 1984 {ECO:0000313|Proteomes:UP000002729};
RX PubMed=21368207; DOI=10.1073/pnas.1016106108;
RA Gobler C.J., Berry D.L., Dyhrman S.T., Wilhelm S.W., Salamov A.,
RA Lobanov A.V., Zhang Y., Collier J.L., Wurch L.L., Kustka A.B., Dill B.D.,
RA Shah M., VerBerkmoes N.C., Kuo A., Terry A., Pangilinan J., Lindquist E.A.,
RA Lucas S., Paulsen I.T., Hattenrath-Lehmann T.K., Talmage S.C., Walker E.A.,
RA Koch F., Burson A.M., Marcoval M.A., Tang Y.Z., Lecleir G.R., Coyne K.J.,
RA Berg G.M., Bertrand E.M., Saito M.A., Gladyshev V.N., Grigoriev I.V.;
RT "Niche of harmful alga Aureococcus anophagefferens revealed through
RT ecogenomics.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:4352-4357(2011).
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DR EMBL; GL833124; EGB10105.1; -; Genomic_DNA.
DR RefSeq; XP_009034938.1; XM_009036690.1.
DR EnsemblProtists; EGB10105; EGB10105; AURANDRAFT_71169.
DR GeneID; 20228096; -.
DR KEGG; aaf:AURANDRAFT_71169; -.
DR eggNOG; KOG1426; Eukaryota.
DR InParanoid; F0Y4D8; -.
DR OrthoDB; 37462at2759; -.
DR Proteomes; UP000002729; Unassembled WGS sequence.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR023393; START-like_dom_sf.
DR PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR PANTHER; PTHR16305:SF35; TRANSCRIPTIONAL ACTIVATOR DOMAIN; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF13540; RCC1_2; 2.
DR PRINTS; PR00633; RCCNDNSATION.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
DR PROSITE; PS00626; RCC1_2; 2.
DR PROSITE; PS50012; RCC1_3; 5.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002729}.
FT REPEAT 246..302
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 303..348
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 349..398
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 398..469
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 470..523
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 754..813
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 1051..1130
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 123..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1688..1707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1891..1978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2395..2439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1688..1705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1893..1912
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1919..1940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1947..1961
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2439 AA; 253686 MW; 6ECC7D03C9170CCF CRC64;
MECRNPYLPG AGRSETRGLA GVGAHASLAS TGPHVAAHSD LRRTTNVASA RRGLDGARYR
ERLQAYAGLS GAGPPPRTGD ARDLAGHLST TSLRHDGAPA AMRAFETAPA LKQAGACSRS
AEALGQGSTW RGPATSARNV DPRARPAAPR PPPPFSRPPA ACARALLFLA NADVAACAAV
SAYWADELLL DYAALRVRFG ALLPGESAPS FLASLAALAA ARGARGCADA LATGSAAHHG
VAFLPGGCVA WGRNDSGQTG DARLAGGPAG PPLPAWVAGL PERTPPVAAA AGADHSVFLD
SDGAVYDCGV DGAGDRPIPR PVSRVREIAR RVVAVAAGER YTLALTTRGD VYSWGECLFG
SLGTGAFLEK RRAPATVGLP RTTRVSAGPH HALAVAGGRL YAWGRGADGE TGLRQRLRAP
AATPAAATRR RDVAGDRAHD RARPEAVALA GDVVDASAGG AHSLAVVAGG AVFGFGLASF
GRTGVDVGWP RRANVWRPEA VALAARVVRV AAGGEHSLAL DDGGGVWSWG RGGLHGRATA
RDAFAPAPVK LPSPAVAIAA HAAHALAATA PGDDGRCAVY AWGRGDHGRL GVADAFGNCD
IRDRATPTVV QWTRRSSAGG RKFEDFVHHP DGSFQHRDDS SFGSQPAFVV VARHGTVLNV
HLLDRPRKDH FKKSTCSDAA TLIIPRCLSA IGAVFSLSEI ILEAHRSLAQ KLRESGEVER
MKTSRLLRSF VPKLVRQDVA SRDPSKRFRQ AQGAVLFADA SGFTALTQSL CADKDGAERL
TGILNDFFGV LIDLVESYGG DVVQFSGDAL TILWRCAESD DDKGLAGGEA QAVILASACA
AAMQRAIAGD ARLAGGPLTM HMALGCGAVT LAHLGGVWGR WVLVMDGPAM AQIALAEPLG
GSGDVVLSPR AAKALRETDG STRADSILEA PYGDAHAAHA RLAMGGDLRA LAAAAAAVKH
SLGDVPATRG SLSGSPGDAA KIAAYVPATV CKQLLLNRRE DKIDASAAEL RHVSVVFAHM
AGVRASAAAA VVEALQRAVG VGEGDVNKIL VDDKGMLCLA VFGLPPLVHV DDATRATAAA
LLVVGELAAL GVAASVGVTT GTAFCGFVGS SVRREYTVMG NVVNLAARLM SAAKREAGRV
LVDAETRAAA ASASASRDFD FRATAPLQLK GLKDRVSAFA PVEVERADGS LASKVFFRAT
RRTPRRRSYL QKLFRQSSLG IHGDPLSRSN AQVGPTRHAQ ELLYGFSRPP ERVWPAPEGA
GAAEARAAGG ALCVAGHTGR GMHAIIDDLC DWGEDKMRWT VFRVDLDDRH ASQAEALRLG
FASRRGDARE TTAWRLAALS MRFARAWILD LAAAAGVDDW RALVPPELRP FAGLAAAVVD
DDAAADDVAL ETSAKETLAV AVIVAALRSG VDRLPGPALF AADVRDSSSS TCALRGGGWR
LLAALGRRCG EATARAAPAP PMLLVVAAKP RDFGRGPAAQ LWADAGERGA ALSLRALGRG
SDAYGTYVAQ CLGGVDDVVD ARDDGGAAAR VAGGDEAPLL GGAAEEPPRD PRRVLEDFVL
EYSGGVPAFV REICRHLVAS KAVVVSGTTA FLHCRRLDAA AHVPPLVATF VKLEYEGLAD
DEKFLLQAAS VLPRFRELVV AADVFRRFFE AGDADATLHA NLRVAALAES LILDDVLTLA
AADDDDDDAA RRARAAPRGD DDGAQPDGFL DQILWICKKT DADAPPALER SGRGSFADDV
DARACARAYG ALEAAEDEAP RRLRFKNRAL RAYVVSIMSK RARSRPLICW SQIVFWPSHF
MDPTKSTRTG PPPSAGAAAS ARGAGGAWRC LATSASLSTA SKDAGLLGPR ASNSSSTCAA
SLRTTDSETT CVAGSTLEST MEIMDVGTWA GSCVPPSKST RISASPGTSP RRWKKTSSRR
AAGSQTWPTG GQTTSARGDR ASQGAPGGGR TATSSSAGDR AARPAASTAD TPTRAATAPP
VAVASAAAAA SGAPTRSGCV PGSEMMSTQL TAPVAPAPTA LTQRARTFAS RTQAATSSGG
SDAIDATTIK LDALGTQEPT NTSKDDLCDV RSLAADARWL DAFDALDTLE SPAPETAEDV
DLVEEVRARG ASFRRARAFC SADADGAATA DGAATADGAV PAAAAATADG AATADGAAPA
EEAWSEGHRA FGVETSYRYD ADGLLWLRTT GEMKDIDLFH TVAVIREIGL FGEWIPFLRH
SDVVHELDFS RLLAHFSIGV RGVLSRDCVM RVAACNDALS SGALYFEGES LADDVAAWRG
AAVPPRYTGW GYDRMHVHSL VAKVAFTSAT SQHAMVVVSV DLRTRLPRSI LDFFLKKLVG
IFLWLWRRQS RYISAHDEGK HRDAIAADAA FYENWLRPKY DEFCAARGWT DTSPALGADE
AEDEVGDDAA LPPGLDGAED GGAAESPAPA VGGDAEAVG
//
