ID F0YB93_AURAN Unreviewed; 1992 AA.
AC F0YB93;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=MBD domain-containing protein {ECO:0000259|PROSITE:PS50982};
GN ORFNames=AURANDRAFT_64731 {ECO:0000313|EMBL:EGB07619.1};
OS Aureococcus anophagefferens (Harmful bloom alga).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Pelagophyceae; Pelagomonadales;
OC Aureococcus.
OX NCBI_TaxID=44056 {ECO:0000313|Proteomes:UP000002729};
RN [1] {ECO:0000313|EMBL:EGB07619.1, ECO:0000313|Proteomes:UP000002729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP 1984 {ECO:0000313|Proteomes:UP000002729};
RX PubMed=21368207; DOI=10.1073/pnas.1016106108;
RA Gobler C.J., Berry D.L., Dyhrman S.T., Wilhelm S.W., Salamov A.,
RA Lobanov A.V., Zhang Y., Collier J.L., Wurch L.L., Kustka A.B., Dill B.D.,
RA Shah M., VerBerkmoes N.C., Kuo A., Terry A., Pangilinan J., Lindquist E.A.,
RA Lucas S., Paulsen I.T., Hattenrath-Lehmann T.K., Talmage S.C., Walker E.A.,
RA Koch F., Burson A.M., Marcoval M.A., Tang Y.Z., Lecleir G.R., Coyne K.J.,
RA Berg G.M., Bertrand E.M., Saito M.A., Gladyshev V.N., Grigoriev I.V.;
RT "Niche of harmful alga Aureococcus anophagefferens revealed through
RT ecogenomics.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:4352-4357(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL833130; EGB07619.1; -; Genomic_DNA.
DR RefSeq; XP_009037617.1; XM_009039369.1.
DR EnsemblProtists; EGB07619; EGB07619; AURANDRAFT_64731.
DR GeneID; 20224971; -.
DR KEGG; aaf:AURANDRAFT_64731; -.
DR eggNOG; KOG1965; Eukaryota.
DR InParanoid; F0YB93; -.
DR OrthoDB; 36962at2759; -.
DR Proteomes; UP000002729; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR PROSITE; PS50982; MBD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002729};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 1008..1028
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1048..1065
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1077..1100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1106..1129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1181..1208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1215..1232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1271..1292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1312..1331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1343..1363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1375..1400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..102
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 852..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 944..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..305
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..974
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1992 AA; 207449 MW; 5394FC443609A189 CRC64;
MPRVEDPHAE QAMEELEDAV EEWGGDASML DGWRTEVHDR PTGSSAGTTD RYYFDEFGKR
FRSKAEIARA LGLAGAPAPA RRASEAPAPP RDRTYDARDG AAAYALSASV AAECAAAQDE
DDAVLERLLL HAAAAARRAS AMADACGAPF RGDARAPPSA RFATVRLKLA EPDEPADDGD
DPPRKRRRRG KTPAWLKPMA CELRLARWPP RVVAVRVAGG RERPAAAAVG DAYWAERRGP
PPPGPARRAL RVRLTTGGKD EVVEEDAADA DAPPVATLGP APPVATLGPA PPVATLGPAP
PEAIPDAAEP EAAAPSPAPS LAPSPAPRAS PAARAAAPAP TEEPLVAHFS LSPQDADVAA
SFRVARGAAA RARRRRLAVA GATEPPEDDG LPEGLGDVNA LLRVADFLGS FAPLLNVAAP
PLEALAAMLA DDGRSKLAAM LAEATHVALC RVALGDRLFA CRRERPEDES DDDDDAAAPS
PAPGKPKADE NADPAKTEKP PDKPGAPALG AEWRTEGPHV GMWITRAVYS NGKQTSSSVG
LVEGYLPPEE ADFLDDAGAP AALWSVRYVS GELAGDREDL EAAEVEESGP RWVRPPRSGQ
GENAAPEDRG AALALRALDD ACERQQWWRP LPPPETLTAA TWPALAAACV FRDARVDADD
AGAGATSKAA LDACAALRAA RGAYGALGAA RRLALLDGLV HACASTAAVS DRCRLRRGGA
DCADLAPAAP APRAAAPAKA GKAKPKASAG GGRAPSKHPL PMAAIAMLVG DAVPLAVRQH
NPKGGASRAR YEGYKSATNA KVFIALGGSK GDLQNDLIKG HIQLLGPDGE PIEWHTHEHV
VAVAVTGPAA GRKAAAAARA SPPRARTPEP RARTPEPAPE PAAAAAREPP AAEPDGPAAH
SLLCGASLAL AEKAGSLPAR PWLVLAVAAC LAIAVLGDGH DDDGSAVSDD GHGDASHGDA
SHDDGHDSSS HAHGGEHANH AAPLILLVVA LFFGVLAKTL LAKSKIPYTV LLLLAGVAVG
WGVDYEGADD KKPLHRSVRA WDRVNPHLLM YLFLPVLIFE SAFSVDVHTL FRELFQVLTL
AVPGVALSTA LTACVARWLF AGREFTWAAS LMLGAILSAT DPVAVVALLK ELGVSKRVGT
LIEGESLFND GTAIVVFNVF FHELRDRGNG GGIDGGEVAV YFLRLAGGGV LLGVLVGGAT
VLGLSYIYDD GLSEITLTIV AAMGTFLIAE MITVDGQALT SGVLAVVALG LIVGSKGASR
VSATVGHDLH ATWEALGFVA NTLIFFVAGL IVEVRLSHSE HVARDLGQLA VLYASLHVIR
FVVLLVAWPL LRRMGYGMDW KFGVALWWGA LRGAVGLTLA LIVEEDHAVH ADVRHAVVFH
VAGITLLSLC VNGTTMEYVL SRVGLSEKSA SAEAEFVAVG RELSLASDDH ARRLRDDDRF
LVDCDWATCL RYLPVHDAET YRTRLAATEA GAAPLMAKRW HGYAKAFGGP NAAPTPTSAK
PPRRRASVAR VLGGAAAADG DRELVALGAA GAAARCDTEQ RRRAARMVRA ELWRLSEAGY
ARATAVDTLL VVCDELRDGV EAGGDLRSWD ARVRPQLDRF AAGGGLGFGR CASRFSARAP
ILDRLFRANL AYAFDVASCY ARATSAVAEA LAGGGCATAD AAGAELAEEA EKASRWLDEY
LGAFPEVARS VTTEAAARVV LARETEDVLE RVHAGELGSR EERVLRAALA ASAARLDFGR
TAIPPPTALA KLKNLPGLAI FDRLHGLGPL AALARRPAYA TGATLCVGES WFLVLRGEAR
CLRAPDAPPR PAASPRRRSV FAALTSPRGS PERPPPFEPA AAAEADVVAT LGAGRTGGLL
ELLAGTPARP YAYVADRLTQ VFEFPNDATK GLMERTPALR DALLAAAGRD FSPEIAALAG
RGDVVARGIV RAGDDLGASD LSSYGGCGLL VGKAGAARAP ALVAWPPGAA PDVADGSVAV
LFTAADMEEL AA
//
