ID F0YFE3_AURAN Unreviewed; 947 AA.
AC F0YFE3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Eukaryotic translation initiation factor 5B {ECO:0000256|ARBA:ARBA00013824};
DE AltName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00032478};
GN ORFNames=AURANDRAFT_54360 {ECO:0000313|EMBL:EGB06180.1};
OS Aureococcus anophagefferens (Harmful bloom alga).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Pelagophyceae; Pelagomonadales;
OC Aureococcus.
OX NCBI_TaxID=44056 {ECO:0000313|Proteomes:UP000002729};
RN [1] {ECO:0000313|EMBL:EGB06180.1, ECO:0000313|Proteomes:UP000002729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP 1984 {ECO:0000313|Proteomes:UP000002729};
RX PubMed=21368207; DOI=10.1073/pnas.1016106108;
RA Gobler C.J., Berry D.L., Dyhrman S.T., Wilhelm S.W., Salamov A.,
RA Lobanov A.V., Zhang Y., Collier J.L., Wurch L.L., Kustka A.B., Dill B.D.,
RA Shah M., VerBerkmoes N.C., Kuo A., Terry A., Pangilinan J., Lindquist E.A.,
RA Lucas S., Paulsen I.T., Hattenrath-Lehmann T.K., Talmage S.C., Walker E.A.,
RA Koch F., Burson A.M., Marcoval M.A., Tang Y.Z., Lecleir G.R., Coyne K.J.,
RA Berg G.M., Bertrand E.M., Saito M.A., Gladyshev V.N., Grigoriev I.V.;
RT "Niche of harmful alga Aureococcus anophagefferens revealed through
RT ecogenomics.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:4352-4357(2011).
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
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DR EMBL; GL833136; EGB06180.1; -; Genomic_DNA.
DR RefSeq; XP_009039132.1; XM_009040884.1.
DR AlphaFoldDB; F0YFE3; -.
DR EnsemblProtists; EGB06180; EGB06180; AURANDRAFT_54360.
DR GeneID; 20222381; -.
DR KEGG; aaf:AURANDRAFT_54360; -.
DR eggNOG; KOG1144; Eukaryota.
DR InParanoid; F0YFE3; -.
DR OMA; EFAVMLC; -.
DR OrthoDB; 169393at2759; -.
DR Proteomes; UP000002729; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000002729}.
FT DOMAIN 341..563
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..267
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 947 AA; 102872 MW; F7216EE450444AC4 CRC64;
MPKKKNNAKK AAAPAGGDDD WDALNEAPAG GESAPAAPAA EPAPAPDPEP EAGEPGGGEG
QDAAAAFLSS MGEGASAAKK KDDKKKKKGK KKGGGGGDDE EKEAPKAQSK AGKAIAERLA
KQRAEEERLA AEKAEQERAI REAEEAEARK EQEEKEKREA KLARKAAARE EAKKAGTYET
KKQKEARLAA ERRLKSMQDA GMLPPSGGRA ASKVEKKKPK EVKPPPAPEP EPEPEPEPEP
EAEVDDWEDA GDDAAVDEEE EDEADLEQKA KDEALRKAGA AFRKREEEKK AEEEKQAALE
AEAAEMADKA AREAELKKRE CRAKRLAREA AREADRSNDR LRSPICCIMG HVDTGKTKLL
DRIRQTNVQD GEAGGITQQI GATLRGHQPL LDKLGYVDAI MGVGGEPQLK LPGLLVIDTP
GHESFSNLRS RGSSLCDMAI LVVDLMHGLE PQTLESISLL KRKRTPFVVA LNKVDRCYDW
KAVDGASIRE TLKQQAANTL AEFESKKQKC CTELNEQGLN VALYWENDDP AATVSVVPTS
AITGEGVPDL LRTVLSLTQQ RLASHLAFSY NLQCTVLEVK VVEGLGATLD VILVNGCLHQ
GDTMVLCTQD GAIVTQARSL LTPPPSRETR VKSDLIKHEA LEGAIGLKIT GDSELTKVIP
GTSIMVMHAD DDVEDIKEEV MKDVSGLVDT LATEAKGVTV QASTLGALEA LLEFLRNPGK
DRQGKERPPI PVFSATVGPI HKKDVIRAAI MAQKGHDEFA CILGFDVPVD PDAQTYADKN
GVKIFTAEII YHLETHFTTH LDAIMEQRRD DARNVAVFPS TFKISPRHVF NQKDPIIVGG
TVTDGILKVG TPLCIPHLGF LDIGVVQSIE INSKDVTTAR KGTECAIRIV NASNPTMTYG
RQFDDKHDLF SKLNRASIDA LKKYFKDDMT DDDWRLVIKL KKVFSVI
//
