ID F0YIS4_AURAN Unreviewed; 1445 AA.
AC F0YIS4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Apple domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AURANDRAFT_66784 {ECO:0000313|EMBL:EGB04941.1};
OS Aureococcus anophagefferens (Harmful bloom alga).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Pelagophyceae; Pelagomonadales;
OC Aureococcus.
OX NCBI_TaxID=44056 {ECO:0000313|Proteomes:UP000002729};
RN [1] {ECO:0000313|EMBL:EGB04941.1, ECO:0000313|Proteomes:UP000002729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP 1984 {ECO:0000313|Proteomes:UP000002729};
RX PubMed=21368207; DOI=10.1073/pnas.1016106108;
RA Gobler C.J., Berry D.L., Dyhrman S.T., Wilhelm S.W., Salamov A.,
RA Lobanov A.V., Zhang Y., Collier J.L., Wurch L.L., Kustka A.B., Dill B.D.,
RA Shah M., VerBerkmoes N.C., Kuo A., Terry A., Pangilinan J., Lindquist E.A.,
RA Lucas S., Paulsen I.T., Hattenrath-Lehmann T.K., Talmage S.C., Walker E.A.,
RA Koch F., Burson A.M., Marcoval M.A., Tang Y.Z., Lecleir G.R., Coyne K.J.,
RA Berg G.M., Bertrand E.M., Saito M.A., Gladyshev V.N., Grigoriev I.V.;
RT "Niche of harmful alga Aureococcus anophagefferens revealed through
RT ecogenomics.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:4352-4357(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GL833145; EGB04941.1; -; Genomic_DNA.
DR RefSeq; XP_009040296.1; XM_009042048.1.
DR EnsemblProtists; EGB04941; EGB04941; AURANDRAFT_66784.
DR GeneID; 20225949; -.
DR KEGG; aaf:AURANDRAFT_66784; -.
DR eggNOG; KOG3764; Eukaryota.
DR InParanoid; F0YIS4; -.
DR Proteomes; UP000002729; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17325; MFS_MdtG_SLC18_like; 1.
DR Gene3D; 3.40.50.11090; -; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG-like.
DR PANTHER; PTHR23517:SF2; MULTIDRUG RESISTANCE PROTEIN MDTH; 1.
DR PANTHER; PTHR23517; RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR Pfam; PF07690; MFS_1; 2.
DR Pfam; PF00024; PAN_1; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS50948; PAN; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 1042..1067
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1079..1101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1107..1126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1138..1156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1168..1187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1257..1279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1286..1305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1311..1331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..121
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 1013..1398
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 862..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1401..1445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1417..1445
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1445 AA; 152886 MW; 40455DCAC0ABA7C0 CRC64;
MLAAHVTPTP VRGRCARPRP LAKVVAPVAP RIVTTEQLAS REKRAVERSW PTFLNVSVFG
CDYHNNHLEV QSVDECKTRC HRLERCKAFS YLKHGGVCYF KTCRETNLRN MSGVDTYVKH
RHSLAPAGSS CPKTRKLRVA PENPAVAVVV TVHDALEWVE RCLAAMFDRT EDAAYGLYLV
NDGSASATLR GLERLVDARG KRDLVRFVNW RGESDLHGYT RAVNAGLRAA LGDDPAIPPP
ATPYGAFCLL NSDTEILTPT WLAALLSAAF STPDIGVVGP VSNAASYQSV PQLRHTNPDT
GKVDWSKNPL PPDWRPRDVA QAVARASKLG LVDVPVLNGF CLLVKAEVFG VVGLFDDVAS
PLPRPPNLFH PKAHLFFRFP HGFGEENDFA LRAARLGYRL KVADGVYVWH HKSKSYGDAT
RKDLSSESRA TLLQRWGPQL RDAVQALERE PALDEARRRV AANLGARNAT EGCRPAALRV
LFVLNPIRRA PQPPAMHGGW ISIVNQAIGL RKRGVCARVA ISAWTLGTFR SNFRDSDDVF
LPYKDNVRTP RDLADALRDH AAAFDFLVAT LFTTVEAIAD VAACHPNVQT GYFIQDYEAD
FDNLDLVLKE KALESYTRVE GMVLFAKTRW LRERVARNHN VTVHAVTGSV DLGAFDAARA
AHDERVRSEA DQRSGVARVV AMLRPSTPRR NPTGTLDVLR RVRARFGDRV DVHTFGCPDD
ELDAFLSASD RSFLTHHGTL RREDVAALFG ASDVFLDMSH WQAWGRTGLE AMAAGCVPVL
PGGSGSEEYA VHDANAKLTN TTEPAEAVDA VGHLVADAKF RNRLRTKAIW TAGDFDLATA
SLTVLKLFCD RLDDAVDRLL LAPSPPVTSR STESSKAPYL SSTERCHAVT RGPACHKTTV
SFDDGALETD AAASDDGALE TDAVSFDDGA LETEAAASEA AASVGASTLR NQTPCLGVTN
APLAMRSASA TVAFFHRRFA NWKWQRKSLP RGLATPSSSK DDGTSGAPPP WRQIAILSGS
SFVANAGFGC IIPVLPSLSE SLSLGAVGVG VILSAPAAAR VVLNVRLGAL ADEIGRRPLM
IAGSALGAAG TFATGSAGSL LELVPARLLA GAGSAATLAG AQAYMADVTE GRGDRGKLLG
VQQAAVALGF IGGPALGGGL AEVLGPHALF HAVGVCNLLC VAGYALLPET HQGTGIAASD
ADAAADADTR ARLAAAWRGP LPPLLAMQLA QYLGYACHLS VVPLRAVDVM AASPGDIGVL
FSTVSAVAIV GAPLGGYLAD FGRRTAVVPA ASLTVLGAAA VPLAADGAQF YAAMIAWGLG
ASLMTPALAA ISADVAPPKA RGAVVSYSRV AQDSAFLCGP LAYGALADAL SPSAAIFASS
ACSAAALGFF AARAPETLPK KAAAPVLPDD DAPPARRDPS PAPPAAMAAT PPKAPAPMQD
PPRDA
//
