ID F0YKV0_AURAN Unreviewed; 649 AA.
AC F0YKV0;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=MutL C-terminal dimerisation domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AURANDRAFT_72554 {ECO:0000313|EMBL:EGB04191.1};
OS Aureococcus anophagefferens (Harmful bloom alga).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Pelagophyceae; Pelagomonadales;
OC Aureococcus.
OX NCBI_TaxID=44056 {ECO:0000313|Proteomes:UP000002729};
RN [1] {ECO:0000313|EMBL:EGB04191.1, ECO:0000313|Proteomes:UP000002729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP 1984 {ECO:0000313|Proteomes:UP000002729};
RX PubMed=21368207; DOI=10.1073/pnas.1016106108;
RA Gobler C.J., Berry D.L., Dyhrman S.T., Wilhelm S.W., Salamov A.,
RA Lobanov A.V., Zhang Y., Collier J.L., Wurch L.L., Kustka A.B., Dill B.D.,
RA Shah M., VerBerkmoes N.C., Kuo A., Terry A., Pangilinan J., Lindquist E.A.,
RA Lucas S., Paulsen I.T., Hattenrath-Lehmann T.K., Talmage S.C., Walker E.A.,
RA Koch F., Burson A.M., Marcoval M.A., Tang Y.Z., Lecleir G.R., Coyne K.J.,
RA Berg G.M., Bertrand E.M., Saito M.A., Gladyshev V.N., Grigoriev I.V.;
RT "Niche of harmful alga Aureococcus anophagefferens revealed through
RT ecogenomics.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:4352-4357(2011).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; GL833154; EGB04191.1; -; Genomic_DNA.
DR RefSeq; XP_009041044.1; XM_009042796.1.
DR AlphaFoldDB; F0YKV0; -.
DR EnsemblProtists; EGB04191; EGB04191; AURANDRAFT_72554.
DR GeneID; 20228763; -.
DR KEGG; aaf:AURANDRAFT_72554; -.
DR eggNOG; KOG1978; Eukaryota.
DR InParanoid; F0YKV0; -.
DR OrthoDB; 4698638at2759; -.
DR Proteomes; UP000002729; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000002729}.
FT DOMAIN 240..378
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 530..639
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 649 AA; 68962 MW; D503D697F9434975 CRC64;
MLTNIAKIDT ASARKLSSGQ VVVDLAGAVK ELLENALDAG ATSIELRIND DGGGAEIECA
DNGHGIAHRV ESISELRQRS QVKICIAPRD FALVAARSAT SKLVNFEELR TVQSFGFRGE
ALASLRELAG EVLVVTRTSA DAVGARLSFQ RDGILKSSTP HARSVGTTVT VRGLFDCAPV
RRADLARRWK WHVSRALRTV QAHALVAVGC RLRLTLVSGG GATRRTAIAV QAPRSLRESA
SALFGHAFAR SLEEVSFDLR GGEDCSLAVI GLMSRAGGFD APGPRGGGGD RQFLFVNGRP
IDAPRVSRCI GDVWRSVEGD RRGRPAFVLD IRVPPSAVDV NVSPDKRDVV LDDETGRGAV
PLPATSNLLV AALRIALHDL WEPSRGSFAG GRSLAPHVAP STTPDTEAPC SLVLPIAVPS
CVTSTATATN APAREAMLVV PPTLRPTQRN SDTIAVAQVI ALSPWQAARA HIDWNCAVAP
ARLHASSVFG TLAVQSRCGH GHRTVQIDRR PGGNVPTAAL AKADFSAMEA LGQFNLGFLV
CRLGDHLFLV DQHAADEKFR YEALWRDTRV DTQPLLAPLS LDLGATEELA LLERRCTVER
VGFRLAVNDL APPGRRVAVI SASALSVLFC GSVRLPSPNQ ITLVSGSGL
//
