ID F0YQQ0_AURAN Unreviewed; 497 AA.
AC F0YQQ0;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=Nicotinamide phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00035036};
DE EC=2.4.2.12 {ECO:0000256|ARBA:ARBA00035024};
GN ORFNames=AURANDRAFT_39495 {ECO:0000313|EMBL:EGB02559.1};
OS Aureococcus anophagefferens (Harmful bloom alga).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Pelagophyceae; Pelagomonadales;
OC Aureococcus.
OX NCBI_TaxID=44056 {ECO:0000313|Proteomes:UP000002729};
RN [1] {ECO:0000313|EMBL:EGB02559.1, ECO:0000313|Proteomes:UP000002729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP 1984 {ECO:0000313|Proteomes:UP000002729};
RX PubMed=21368207; DOI=10.1073/pnas.1016106108;
RA Gobler C.J., Berry D.L., Dyhrman S.T., Wilhelm S.W., Salamov A.,
RA Lobanov A.V., Zhang Y., Collier J.L., Wurch L.L., Kustka A.B., Dill B.D.,
RA Shah M., VerBerkmoes N.C., Kuo A., Terry A., Pangilinan J., Lindquist E.A.,
RA Lucas S., Paulsen I.T., Hattenrath-Lehmann T.K., Talmage S.C., Walker E.A.,
RA Koch F., Burson A.M., Marcoval M.A., Tang Y.Z., Lecleir G.R., Coyne K.J.,
RA Berg G.M., Bertrand E.M., Saito M.A., Gladyshev V.N., Grigoriev I.V.;
RT "Niche of harmful alga Aureococcus anophagefferens revealed through
RT ecogenomics.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:4352-4357(2011).
CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-
CC ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and
CC nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00035007}.
CC -!- SIMILARITY: Belongs to the NAPRTase family.
CC {ECO:0000256|ARBA:ARBA00010897}.
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DR EMBL; GL833438; EGB02559.1; -; Genomic_DNA.
DR RefSeq; XP_009042743.1; XM_009044495.1.
DR AlphaFoldDB; F0YQQ0; -.
DR EnsemblProtists; EGB02559; EGB02559; AURANDRAFT_39495.
DR GeneID; 20221989; -.
DR KEGG; aaf:AURANDRAFT_39495; -.
DR eggNOG; ENOG502QSGN; Eukaryota.
DR InParanoid; F0YQQ0; -.
DR OMA; TFGFAMK; -.
DR OrthoDB; 312306at2759; -.
DR UniPathway; UPA00253; -.
DR Proteomes; UP000002729; Unassembled WGS sequence.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01569; PBEF_like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR041529; DUF5598.
DR InterPro; IPR041525; N/Namide_PRibTrfase.
DR InterPro; IPR016471; Nicotinamide_PRibTrfase.
DR InterPro; IPR036068; Nicotinate_pribotase-like_C.
DR PANTHER; PTHR43816; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43816:SF1; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; 1.
DR Pfam; PF18127; NAMPT_N; 1.
DR Pfam; PF04095; NAPRTase; 1.
DR PIRSF; PIRSF005943; NMPRT; 1.
DR SUPFAM; SSF51690; Nicotinate/Quinolinate PRTase C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW Reference proteome {ECO:0000313|Proteomes:UP000002729};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 3..100
FT /note="Nicotinamide phosphoribosyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18127"
FT DOMAIN 171..410
FT /note="Nicotinate/nicotinamide phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF04095"
FT REGION 461..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 179
FT /ligand="diphosphate"
FT /ligand_id="ChEBI:CHEBI:33019"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
FT BINDING 202
FT /ligand="beta-nicotinamide D-ribonucleotide"
FT /ligand_id="ChEBI:CHEBI:14649"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
FT BINDING 229
FT /ligand="diphosphate"
FT /ligand_id="ChEBI:CHEBI:33019"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
FT BINDING 291..293
FT /ligand="beta-nicotinamide D-ribonucleotide"
FT /ligand_id="ChEBI:CHEBI:14649"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
FT BINDING 291
FT /ligand="diphosphate"
FT /ligand_id="ChEBI:CHEBI:33019"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
FT BINDING 333..334
FT /ligand="beta-nicotinamide D-ribonucleotide"
FT /ligand_id="ChEBI:CHEBI:14649"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
FT BINDING 364
FT /ligand="beta-nicotinamide D-ribonucleotide"
FT /ligand_id="ChEBI:CHEBI:14649"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
FT BINDING 372
FT /ligand="beta-nicotinamide D-ribonucleotide"
FT /ligand_id="ChEBI:CHEBI:14649"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
SQ SEQUENCE 497 AA; 53863 MW; 0959E5C864384CEE CRC64;
MDNILLLTDS YKVSHWKQYP AKTTTVYSYF ESRGGKYDEV VFFGLQYYVK KYLVGEQVTK
AKIDEAERFY GEHFPPGFEF NRAGWEHILE KHGGRLPLRI KAAPEGTVVG AKNVLMTVEN
TDPACFWLTN FVETLLVQVW YPMTVATHSR EQKKVVAKYL DVTGDVAGLG FKLHDFGFRG
VSSVETAGVG SCAHLVNFLG TDTVAGLVVA KDYYGAESAA GFSIPASEHS TITSWGESRE
VDAMRNMLEV YPAGLVACVS DSYDIFKACG DLWGTQLKDA VLARDGCLVV RPDSGDPPST
AMRVLTILGD KFGKEKNDKG YWVLDSHVRV IWGDGIDYEM ICAVLSTLAD AGWSADNIGF
GSGGGLLQKL NRDTQKCAFK CSSIVVDGAA RDVFKDPVTD KGKASKKGRL ALVDVDGTLT
TKTQCAPGPV EGDVLATVFE DGALLVDDTL ETVRERAALP PLDTLPLPRG KSAAPPPPLK
KPEVLAACPT LGGMLGF
//
