ID F0ZCT2_DICPU Unreviewed; 872 AA.
AC F0ZCT2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Ras guanine nucleotide exchange factor {ECO:0008006|Google:ProtNLM};
GN ORFNames=DICPUDRAFT_53443 {ECO:0000313|EMBL:EGC38273.1};
OS Dictyostelium purpureum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC38273.1, ECO:0000313|Proteomes:UP000001064};
RN [1] {ECO:0000313|Proteomes:UP000001064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT Dictyostelium purpureum.";
RL Genome Biol. 12:R20.1-R20.23(2011).
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DR EMBL; GL870980; EGC38273.1; -; Genomic_DNA.
DR RefSeq; XP_003285230.1; XM_003285182.1.
DR AlphaFoldDB; F0ZCT2; -.
DR STRING; 5786.F0ZCT2; -.
DR EnsemblProtists; EGC38273; EGC38273; DICPUDRAFT_53443.
DR GeneID; 10502429; -.
DR KEGG; dpp:DICPUDRAFT_53443; -.
DR eggNOG; KOG3417; Eukaryota.
DR InParanoid; F0ZCT2; -.
DR OMA; CNNRIEY; -.
DR OrthoDB; 1654263at2759; -.
DR Proteomes; UP000001064; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF367; RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR E; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001064}.
FT DOMAIN 418..567
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 598..834
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 71..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 872 AA; 97709 MW; 4528F4C502A5B0A9 CRC64;
MDHTECNNRI EYLNNQNLIL KNKIFELESL NENLKSQVEY FQTKFLESNL MSEGKDISSC
LTEIYNSLSL DNSSNNSNNI SNSSSNNSNN SNNNNKIINL RNNSNRNYKI NLTANTNSNN
SSANTSPFIC SNNSDTSNYE SLPQLSDSEN SSPVLTSQPL PSTPTTISTT PSSSNRPPPP
PRPAFLRSTS DNFEDLNNSS SNNTPTKEFS SSQTSSPLNK GSTWSTAVIP LKMRSETIVQ
QKSPYSPDTT LTNLNNKLVN ELNINNQNNQ NNQNNNNNSN GSVESPSKLT PRGVSNVSSS
PTQSQIDRRS KTSPFPANVT PPLSSSGHLV RTASASSANA IKPQQLSNSC SANITSANNS
RPSTPVQNNS FSIEATGSPS TQSGLYNPFE ITEDEPEVLD DPKLVIAKVT SDGASSTPSF
IVKGGTIEKL VNRLIARHDP DFASAFLLTH KSFTTSGELL DLLIEFYLNN KPLGHAPSLS
SSTTSISSMD LTSSTGSFSS QSDEVKRKRA IRLKITNVIK SWVDKHYYDF EEDKQLIAKL
DNFINTHIMQ DMDKIGINLK RLLSNDRIVP VPIFSNGPPA PIPPKIKNGS EVSFKDLDPT
EVARQLTLFE SDLFRKIGAK ECLGQAWNKQ DKEEKAPNIV NFIKRFNQVS SWVATEILRQ
EKLKDRVSYI KRFILLAQKC RELNNFNATM EILSGLQNSS VYRLRKTWER IEAKPILKNT
YDELMSLMSS NANYKNYMQE LHNIHPPCIP YLGVYLTHLT FIEDGMKNHL NQDEEIINFE
KCRKISVVIR EIKQYQQQQY HLETEEITQR YLNNLPSIQS QKSMYKLSLI CEPKEKESSS
FDSGYGSISD RPDKVKKEFS MTSLLNSWKN NN
//
