ID F0ZEB8_DICPU Unreviewed; 4664 AA.
AC F0ZEB8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=HECT domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DICPUDRAFT_86857 {ECO:0000313|EMBL:EGC37729.1};
OS Dictyostelium purpureum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC37729.1, ECO:0000313|Proteomes:UP000001064};
RN [1] {ECO:0000313|Proteomes:UP000001064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT Dictyostelium purpureum.";
RL Genome Biol. 12:R20.1-R20.23(2011).
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DR EMBL; GL870992; EGC37729.1; -; Genomic_DNA.
DR RefSeq; XP_003285750.1; XM_003285702.1.
DR STRING; 5786.F0ZEB8; -.
DR EnsemblProtists; EGC37729; EGC37729; DICPUDRAFT_86857.
DR GeneID; 10499242; -.
DR KEGG; dpp:DICPUDRAFT_86857; -.
DR eggNOG; KOG1426; Eukaryota.
DR eggNOG; KOG1477; Eukaryota.
DR InParanoid; F0ZEB8; -.
DR OMA; IINSACI; -.
DR OrthoDB; 8391at2759; -.
DR Proteomes; UP000001064; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:EnsemblProtists.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0106072; P:negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:EnsemblProtists.
DR GO; GO:0051896; P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:EnsemblProtists.
DR CDD; cd00821; PH; 1.
DR CDD; cd12885; SPRY_RanBP_like; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR043366; HECTD4.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR044736; Vid30/RanBPM/SPLA_SPRY.
DR PANTHER; PTHR46435; E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED; 1.
DR PANTHER; PTHR46435:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001064};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 2236..2424
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3347..3484
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 4289..4658
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 96..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1016..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2090..2120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2226..2264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2505..2531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2653..2677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2852..2882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2897..2954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3188..3267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3385..3404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3784..3820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4146..4258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1033
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1084
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2852..2871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2903..2948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 4622
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 4664 AA; 527942 MW; 26A5BA0F6012F71A CRC64;
MGNGNSHIKE VIDLSPRTLA LTSVDDKVWL GIPEENLFND SFTIEKYYML QSKPLSNFKD
IDHYNSIEQI EETSFFSSYK DRSNLPLQQQ LQEQLLQQQK QQTQHTQINQ TSAASNQANG
RNSTNLTSGN NNSGASNSTT NNSNNNNNNQ TISEFIEEYK NRSSIPVFLI PEDPYKTHQK
TLSFVLEDLY SQSNVNTAYY TTLLQKRLCI LKRIHLALKR EIARKKLFDS IYHSKAKTRT
KKVHMPPISI RIACRLFLST LQEQVFEQKI SLSTLKSFNI MIKELPPLSM AGEPQDCIDS
LNKWLLSALS SSSPLIKRES MEALIGLSLS QGSLSSILSS LSLIITPDKI ITNNTNNNNP
TTNSGIGVNN SNNSNNSNNT NNSNIGLRMS MSIKQLEQWK VDLPLSPLSR DLLLATWPIQ
WNDNIYDDSL AFLSSSNYNI ATITSDSEYI YIHDTCGLAK IGTGYFGTHQ GRVYARNADF
YPKEKGWLVN IGNHLYYRSP SITENSTLIV LNPMNLEEIG HINQDGSGSI QTVNNLAFPF
GPECHDYIIT SSTSSSISTP TSNFLNNNNH NSNNTTHQLI SNTNRSPIFT DGRYLYLLSL
QRFHNFSNKQ FIVDMYDPFE SFQHYKRIEL RYPDGEVVNH YQNEELVLNP NVLDLGSFYT
NGHYLMVVLP PPLGSDYNYD SKSFICRAFS LSDGSLIGNY CLENQPIGLA SFYDYLNNVI
WNYSSSESEI GKYGNEGFGP KHNFPSIVQK SNTNNTTINI NITINIPVGG NLTPQPILLP
SSSTITTISE EDSDPSMDPK EMVSTILSIL SRLAVDYMPS ASDNAGGPNS STSSIHHVHK
LTEPYSVEVC FNTFSQLYDI LEHYRFNQLK PGGFSATSPK TIETLRCIIY CLRLLKVNLF
RLTSNIRILE RNQQIYQDAS RDNLLKCIDQ NFLHKLRILL LNFVIDGIDS FNESKIASSS
SSKEKERDSI AEFETIREES CEVLTIGLDL FYPTSLDKAN FIFHLLDQFS KNRLPKDKEK
DKEKDKEKDK DNSNLLTNTL PATIANLKPT NLKKNLSNNN NNSNSNNNNN NNNNNNNNNQ
IFKSDKDQGY SMLLNRVLIL LSSHPNASFF ALPPLSSEFS SFSLVNINNF TNNSNNNNNS
NIDSMNLFVP IITHLLQEAQ ATIPPQTIIP QISRQDSTQH LGFSLYSSAS PPPLSSPAMR
LLLAIQKDLI LRVENSVNEN DAPCQALVAY SKLLMDKCKE LLIGVLDMDS QKNQSILLTD
FKSSVVGALL PTLIHSLFLF SYRISLAKEL LPPLVQLMGV VDRVNRRLPK LLNRPELGRQ
PLQKRSSFVE GPSRISESPH PYHAYMNTRQ PVSIPGAVFL SLVFDDRSYT SSLDDVLQIF
ESQDSKEPLE QFSHTKWPKR RILIPGDTVV FQFITGPVNP SNTYSNFWGY RCNIIGHMPN
SDKTSLPWSS HLEKTMCCLA GRFSSCLISG EALTGLELEN SHFLESPLFS GGVEEDFVSS
VLFSNNNESY DLPYLNQAQD ISSPSQQSPP INTKRNNEVY SNHLSDFMWK HVTGEKLKGK
ATIKSAQQAV IAALIKHLGL CDLALNFTLE IIQYKQQQQQ NLNQQQIKPP QPLVDVWKSV
LPIRMTIIQR HQESQLSNHQ IDDMAESQKR RSVDMKTHSE FRESIYNEIA DKIIENSMFL
LELQSYYDPS IILSNQNHYH HNHLSSSQLK QEISSILFKF VLSNNLQIND IKKILISRRS
RAYSRSIGLQ AMHDILRCAS DHSMKPEALC FIGPALRNSG LVKRRCPPYH YLDFLHGSGT
KLIRDVKKNF KLLMEDVSAL LNDQNSDSIL KLYALDAFTL NFSPDDSEML TQVDIFNKIH
NLMTNESIWG GIWGSTGDHN HRNSIGSSPS GSILHSNSTS SLYDNDVGYP PYSSHSIYSS
FVEEEKLERE KLKKNAKALF KFLGLICVDI TQQPTVNNNS NNGVKFESLR DSFFTLMATQ
LESSLVFLKE TNKTYWGRNS SGDTNTPGVS SPNTNVKSRR LYRVEKSYVD LSDSLSLLYI
LSAFDNVKQR LCSVTFINIF HCILQVGDET QRKLILRIFR RILPSVSPYK FNNNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNQNKTLFSL LLEILGAVSY WGCSSDIQEI SKYIDPRYFI
SSNNFNLYRS SSYNSTKIDS PHSYFSIFDK TTQFPCSWDI ISQSPYIKFS DDGKIATFIS
PQNNNFANRS GIPRNNNNPS NTTSSTPITS TGSRPNVSTN QSTNVVGTVT SNSNFSILSN
NLEIIQGLQL VKSDIMIPES TPFFYFEVKI EIETKDIIIG LFPANSIDQL RSLRDWRFGL
GYSSKDGHKV CYRVTSTQSR GYSNGFSRND VIGCGYNHKD GKVFFTKNGK YLGTAFKNVM
GDFYPVVAMS SGGSVSVNFG QQPFQYDLTS IISYHLEFLS ERSTPSMTLS YVNEIVSLLR
ILMKSPQWKQ PLLKYVMEGL KLLPSTIQSN IIPISILNDQ NNINSNSGAN SNSSDDASGD
TSGNNNSSQP KIQNTIHIPK FLSNKTNIQS LFQVFSTVSF ISGYLDGIWP GARVEVDIGS
GCFEYGTVVE YSTQNHLCKV LLDCNVDKLI KTTHNRIALK PIQEIPIDFG IFSNPTLILQ
SISTFLKPPL PTKDSIPSSS SSSSTTPAPT NENSNSLKQS SFNNFKQWHL LNEIIYSSTN
LSNSSNNISN SLPTTNPAVS SSLPTSTTSV TFNLPKNINN SNNIPNDSQL SLSNMSISNA
VNNIRNIYLY IKSRVMKIFS GLLKYSECSK YTLDESLIPI LVEFALGRPI QFMEEPKIEK
MERLSFLLKE KIYDKTLKSF LNNSLGHQFN SVGRGRGRNK TVSSNNQEEN VEELTSEFDF
EEDNEIGEAL NEFDESLDNF DDEDNTTQAN NDNNEDSSPH SSNYSVGNRS GGRSNTILQQ
SQQQQQQQDD YDEIDEDESL QGAIADDDLP EEGIPGKKVL WADIKIGMHV LISKRERLLL
RNSNWVHEMD DIIGHVGIVK SIDKKYRQVL VSFLDDETLT TVDWWMCYET FTYPNEKSTK
NPIISIDKYS HSQLIHLDTS CEMALSILYS RQALISLLVT LPNTSRVSYQ SFGGAKNLIY
ILKLTLYTTL LNDSSNYILS SNSITKLLNV SPKNYKDYIN LKSLQSKLSL LLKQESNNLV
LINHSNQNHN HKVSSNSHSN LPSLTSLNTN NGNSGNVPSS SSQSSGRRSN PSSATSTPTK
TTTISSKDGS SSSTNSTPTK WKSYKPDSTY NYHPTAALGS NVLNNSTNII IGGNTSNMLQ
NNHKNTIEAN NSIITNNKMN ENNISNNNHP TATTTNYIIN QSLIFGEPLK TGNLMKQQKI
IKLWKRIYVV LSSDSIIFYK PQNQQGGSLG HQNKDQHTHQ HHNTIHGLHL SGTNNNPIGS
IDLRDIVSVT QVSLVKQNKI SFSGSTKKDF CFQITLTSNK THLFQASSQE DLNDWIQIIN
SACISSASFR SKPPNFQSTI PLIEVLTKEV CVQLKESSNE SPHIHHEESP HPYPANYCIK
KIVRIEGSQS LLITFDNKSY SEPGLAVLRF FYDPSCTNHI ASYSGKFSSF PPTIINSCQF
WMVFTADTMR SEWGYKFTVT PIRNKTTDVS LLPQPSFEFA CFIVDWVLQL DIQLFKNYPN
FFSQDLVDML LLHLNINQPL DRKLKAINFL TRLLQKLREN PIQLLSITTQ KEISSKIEFI
KDEMFKLYKI ECGNNNMFTN NTLNQPILSQ YLQKLIEICI QTHIVLSQAN SSQLLYLQQQ
QQQQQQQHIP ENDQSSNNIG PSSNNNSNNE LSSSNSSSNN GSSNLYLNIN NTNININSNY
NYSVFNIRDE HKQWFSKMIK TSKVLEHLFR GKGFGKEFIK ESFIETRSKQ VIDSPHPYPP
GARVTSNIII PDSVSLKIEF DPKSRTQTYV DYLMFSKSTP GADDLGFFTG EFPTQPIFIQ
GDRFIWSFYS DSNEPEWGFR FTITPQFSDD VIRENDQKYE REILMLSRNT WNHSMDLELV
KLVNAICEKQ KKNPYQLIFE QCLIPEYLTL FPSLSEIEDH HILYLRFVVL KHFNSLIQSF
INYIDLKGAS DDWSISYKLC SLRGLLFNDC KLEILNNSLI QTKSLSRRPI IHLNRHGSLL
ITTTQPIQQP QPQPQNRNQN NTTITLNPNR TSLRTGNNQA TTTNLNQRNS NNNNISNNNR
NQRASTLTAT SVPTTSTAAT LNNTNNNSTT TATNTAQQQS LPQQQQQPSE QPQSNPASSL
SIITSKNYLY NYKNENLFLQ SFRQLCYMDP LRLKHNDRAW EVKLEREGAR DAGGPYRECM
TQIVTDLQSR EMNLFLPCQN AQGDVAFNRD KLVPNSSANS PLALQLYEYI GRLIGIAIRT
KNCIELSFPS IIWKSFVCAK VERVDLEAID KYTTNFIELL EGTSTTNETK LTPDIFPDCV
DQTFIARSID NNEVELIPDG RLIPVTWENR SEYASLLEQY KLSEYRLQID AMVKGASSII
PLQILNLFTW QEIEQRVCGI PGLDIKLLKK HTRYCGLLPS EARVAWFWRI IESFSSEEQT
LFLRFVWGRS RLPSPSEFNF QFQIYPFIKN QSRIYDDDFE DQRLSEDHDQ IQDEYLPEAQ
TCFFTLSIPN YSSLDVMREK LLYAITSCRE IDADYIVAPE NNLY
//