ID F0ZF38_DICPU Unreviewed; 1681 AA.
AC F0ZF38;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Kinesin motor domain-containing protein {ECO:0000259|PROSITE:PS50067};
GN ORFNames=DICPUDRAFT_149960 {ECO:0000313|EMBL:EGC37470.1};
OS Dictyostelium purpureum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC37470.1, ECO:0000313|Proteomes:UP000001064};
RN [1] {ECO:0000313|Proteomes:UP000001064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT Dictyostelium purpureum.";
RL Genome Biol. 12:R20.1-R20.23(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; GL870999; EGC37470.1; -; Genomic_DNA.
DR RefSeq; XP_003286034.1; XM_003285986.1.
DR STRING; 5786.F0ZF38; -.
DR EnsemblProtists; EGC37470; EGC37470; DICPUDRAFT_149960.
DR GeneID; 10499830; -.
DR KEGG; dpp:DICPUDRAFT_149960; -.
DR eggNOG; KOG0244; Eukaryota.
DR InParanoid; F0ZF38; -.
DR OMA; HKQRVIQ; -.
DR OrthoDB; 9262at2759; -.
DR Proteomes; UP000001064; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblProtists.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:EnsemblProtists.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR CDD; cd01372; KISc_KIF4; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR47969; CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED; 1.
DR PANTHER; PTHR47969:SF15; ZGC:66125; 1.
DR Pfam; PF00225; Kinesin; 2.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Reference proteome {ECO:0000313|Proteomes:UP000001064};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 12..394
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REPEAT 1344..1386
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1393..1427
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1515..1554
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1647..1681
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 450..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 773..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1247..1311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 640..706
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 933..960
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 842..871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1254..1304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 92..99
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1681 AA; 188786 MW; D62758DDBD66D6AD CRC64;
MSNNNEEHNE NCVRVALRVR PLSTKEINER SVEVVKYVDN EPQVIIGDKD QTFTFDYVFN
GKSKQEEIFD QCVYGLVDSL FEGYNSTILA YGQTGSGKTH TMGSTSTVGI DSEDLGVIPR
VIDLVFDKLE SKKDTHQIVL KVSFLELYNE EIRDMLNPYP APGGLPIREK SNGEVYIPGL
VEEVVRSRKQ MEDALIRGSQ SRTVGSTLMN IHSSRSHAIF SIIVEQTPIN SPHITRTTTT
PSLDGNCLPL KKDNSNDSID GGGTTVVEEI DLDDEDMSMD ERNPSIRSMF HFVDLAGSER
VKKTKAEGQR LKEGININSG LLALGNVISA LGDTRKLNNK AKHIPYRDSK LTRMLQSSLG
GNSKTLMVAC VSPADSNFEE TLNTLKYAYR ARNIMNKPVV NIDPVTQQII LYKAQIQLLK
DTLEKCSCRD LDIHTILSQM PTTTIEIKPA SLPSSNISNN NNNSNSNNSS GNSGFRPSRS
SSSLSSSSAT APINRSKPNN NNSNQQQAHQ HQTNNVVVNN SIDKEKEKEI FDLNMKVSQL
EFENNMLEDI SNKVTSKYKA LANKNKQLEE LAYNFINNFS PNKDQTFFNE VFEQFNSALN
NTNQQQLDDQ PQQDQNQNPN EGIEFFEDDS EELSDLSQYI TEKEEELELI SKTKHQYQQM
KEQFDQKLKE LESQLEEVRE EKDQALKALE KDNTIGNEKV ASYEDEKYRL TQFYEKKINE
LKSQLDQHSG SNKKDYQRLL DLKRKSEEKI DSLQQDIKDT KRQKSDLLKK MRDELKKRDD
AKQHQAKELE SLKREARKSG VIIDQLKNQS KKKDLLLQKK IDESESYKRK LKDIETHKQR
VIQPIKPSST KPPVSSLFSS SSSTASGTNK KPLRKSIAEP YWREWIINQI QKNLERNELQ
ELLQKDFKNK ELFVRQSNDL KKAFTSTPPK LSKAEYNEQS QFLEQNIKNQ NEKISKSQTQ
LAIISNDCLD APEILRMVSN TSFDKLPKLI QSALELCIEY AELNRKNQQI LNNLSKSSPS
PSSLLSTSNT MPPPLSQNTT NIQPIHPPIS EQALEQRSSS FALMEGIKAA KLERKNSENI
NTNVNITNEI NNKPNQLPQK QLQQLPSQPA IISETTTPQD YSSPSTSSLG QKLDQLLEEI
KLDKEKREKN RLLNGYPPMN NNSSGNNNNS GFTPILVSPQ PITTSSPLSS QSLPNNLNHP
SKNIAPLNIS SPSLLVTSLD DNILDHSVFD KDFLDTDIAL DSTLKKGTLS PTHKHKKTIS
LQNSPIGLAE GNSSSNPGGS SINSSTGSTG SLSNDVFTRL SSQPRPDSRL KKYRDKLNID
DYLLAIKKNT HDPNENFLRC NWTFNGHDGS LLTLTLDEQN PKILYSGGSD KNIKLWDLNT
GDNMMDLSSP GPVRSLCVNQ SSGFMFSGGS ERIVKVWDIR SPSNANLSIF KTPSDVTSLV
TYGNYVVAGL ENGTFKVWDI RHMQKPLKTP LTTISHHSGS IFSMSTTSKY LVTASRDHTI
NLFHRDSFVL AQKLQPPHHD GVTSIAVLDD VIYSGSRDKS IKKWEISSSN ILNLSNTNPI
ETIPTNTLNN NSNSLLPQQQ AQQVPPNLKT STDTLFVSNQ FQQTRLLNNA HNDWVNCLCI
HNGTVFSGGK DSNIKGWDPN FTSNNLLVGH DSSITCMISS GKEFLFSGSV DKSIKIWKPS
N
//
