ID F0ZZN9_DICPU Unreviewed; 954 AA.
AC F0ZZN9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DICPUDRAFT_41248 {ECO:0000313|EMBL:EGC30596.1};
OS Dictyostelium purpureum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC30596.1, ECO:0000313|Proteomes:UP000001064};
RN [1] {ECO:0000313|Proteomes:UP000001064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT Dictyostelium purpureum.";
RL Genome Biol. 12:R20.1-R20.23(2011).
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DR EMBL; GL871316; EGC30596.1; -; Genomic_DNA.
DR RefSeq; XP_003292884.1; XM_003292836.1.
DR AlphaFoldDB; F0ZZN9; -.
DR STRING; 5786.F0ZZN9; -.
DR EnsemblProtists; EGC30596; EGC30596; DICPUDRAFT_41248.
DR GeneID; 10509064; -.
DR KEGG; dpp:DICPUDRAFT_41248; -.
DR eggNOG; KOG3519; Eukaryota.
DR InParanoid; F0ZZN9; -.
DR OMA; KPIERMI; -.
DR OrthoDB; 8607at2759; -.
DR Proteomes; UP000001064; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR CDD; cd00821; PH; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45834:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L; 1.
DR PANTHER; PTHR45834; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001064};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 159..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 596..777
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 800..901
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 62..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 954 AA; 108247 MW; EAFE974E1CB4D7AC CRC64;
MIDQSEISNT PSISVSRVGM LGYDSVGSGS GQNMMDDTAS NISGSVSSFY TRSSMKNRNL
ILSNGNSSVR SNHSNNNNQS PEKPKKKFGI LHHSIHFSSI GGLFSMQNLP NQKSFTDLGQ
KIFHGKGIRK LRSMKRRRNA KKSTKSYARR KKISQLMNSK WAMIVMIVAT IYLLYIDDLL
LTTLAPNTSA SYNIVSVIKV IVFLIFVIDM IFQIYVQRLN YVLTLFFPID LVSIASLVPD
VIGYIFGLTS IVYALNSLSI SRTARVARMA SRLSRIARII NFFDVFQCGK RVQEKNKNEI
QLSVEPSTIG KKLLSKTSHK IVVMCLLIVL ITILTSPTLD QHKYFFSILE LLVISATQNG
LASPAFQAAF NDIQENRDTV DLLYLNINNT LVYQSPIDTD LWYPSYIIKI DSDNNEMWVN
NQRNEQILAA LSITMTTCLI IILCVGTLLI SYDFQKLVIK PIERMISLIK KISSMDRGYG
SDYDDSDQDE YTGGADGVDD EGGDAQMADM EVGGFSSGGE SDFESFGDYG TEEHETEILV
EVLTDLASKK MNNFNKEQQA QEAKQQVING LNYLVAGIKA YSQRKHYNGE LKVYSRRGRI
VKELLTTEQS YVNSLNIAVE HFLIPIRTNS HISNEDSTTI FSNIEVVHQF NKGFLEIIEE
KVNNWHFNQS IGESFSYMES ATQSYSTYVN NYNNAIKALE DAKKEEKFAE FLQETREQKA
KGIELVGYLI MPIQRMPRYV MLLEDLLKHT HQQHYDYEHI DNAVKNLKKI TVQLNERKRE
SENKQSIQDI YMKLVPPVQD ILVPGNSIVM QSKLKQDGDK FYFFLFNSGL LKAAKHENEL
HVKQYIPIKD IVVQLSVLQD VPSLKFFNAF QIKIEDEMVL VFAKTPEQRQ EWITAFAQFT
KVQTQRTKSV LMMNNHLRKS TISRNSLGGS LTQSQSPSLN HSRLSVSSAS SKKQ
//