ID F1A281_DICPU Unreviewed; 576 AA.
AC F1A281;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Ras guanine nucleotide exchange factor {ECO:0000313|EMBL:EGC29698.1};
GN ORFNames=DICPUDRAFT_158689 {ECO:0000313|EMBL:EGC29698.1};
OS Dictyostelium purpureum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC29698.1, ECO:0000313|Proteomes:UP000001064};
RN [1] {ECO:0000313|Proteomes:UP000001064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT Dictyostelium purpureum.";
RL Genome Biol. 12:R20.1-R20.23(2011).
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DR EMBL; GL871402; EGC29698.1; -; Genomic_DNA.
DR RefSeq; XP_003293780.1; XM_003293732.1.
DR AlphaFoldDB; F1A281; -.
DR STRING; 5786.F1A281; -.
DR EnsemblProtists; EGC29698; EGC29698; DICPUDRAFT_158689.
DR GeneID; 10505099; -.
DR KEGG; dpp:DICPUDRAFT_158689; -.
DR eggNOG; KOG3417; Eukaryota.
DR InParanoid; F1A281; -.
DR OMA; FNDFTKW; -.
DR OrthoDB; 9093at2759; -.
DR Proteomes; UP000001064; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblProtists.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:1905742; C:Ras guanyl-nucleotide exchange factor complex; IEA:EnsemblProtists.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0030295; F:protein kinase activator activity; IEA:EnsemblProtists.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IEA:EnsemblProtists.
DR GO; GO:0043327; P:chemotaxis to cAMP; IEA:EnsemblProtists.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:EnsemblProtists.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF203; RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR H; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001064}.
FT DOMAIN 196..310
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 339..566
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 576 AA; 66781 MW; 136B220D0E8965C9 CRC64;
MSNNPIVQQI HNTPQKKLTN SQYSTFSGSS GQDGINDNDS FVNFPASEWL SKAMHKHSDI
LELRERTRPI TNSKSYSRNK RAGKTEASHA INDTILLKMV MQYLHEENLT TSLKKIQEET
KLQFVPNEVD KDTLENLLRI GIKDINWFGP LANNEDPDCE VETYHAYNSD DSNENNLEEG
NLADDRYDES QIIRNPDMTI QAASLNRLLL WLVGNFNGQD ANEKKIFFLT YPSFTSAETI
LNKFIQIYHS FENIDSAQVI CFIKVWIEQQ PTDFNEKLLA ILNNFIDHQV ATAHAKQLRA
VISSKIEKKE TQRREIKDPP EPKVPKNIFS PTLTFDDIDE EEIARQLCVI DFGLYELIKT
SEFLIKGWTK PQFRSKAVNL LNMMRRFNDF TKWIASSILN EQNSKGRTKL LGRFLKISEH
LRANNNFHSL MAIYGGINNT HVFRTKAIRK DLSKQQQETF ADLEKLFSSE NSFRNYRINY
KDAKPPCIPF LGIHLRDLAF VDESNPDRIN NLINLNKRRI IWKVITNTMR YQPMAYNFLK
VHQISLFLTE LKIDVEQTQP LDFSPDTVLP NSTTKQ
//
