ID   F1AEM3_9NEOB            Unreviewed;        78 AA.
AC   F1AEM3;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   SubName: Full=Preprobrevinin-2CE {ECO:0000313|EMBL:ADD51562.1};
OS   Rana chensinensis (Chinese brown frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana.
OX   NCBI_TaxID=79015 {ECO:0000313|EMBL:ADD51562.1};
RN   [1] {ECO:0000313|EMBL:ADD51562.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Skin {ECO:0000313|EMBL:ADD51562.1};
RX   PubMed=21303203; DOI=10.2108/zsj.28.112;
RA   Zhao J., Sun Y., Li Z., Su Q.;
RT   "Molecular Cloning of Novel Antimicrobial Peptide Genes from the Skin of
RT   the Chinese Brown Frog, Rana chensinensis.";
RL   Zool. Sci. 28:112-117(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GU561637; ADD51562.1; -; mRNA.
DR   AlphaFoldDB; F1AEM3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR012521; Antimicrobial_frog_2.
DR   InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR   Pfam; PF08023; Antimicrobial_2; 1.
DR   Pfam; PF03032; FSAP_sig_propep; 1.
PE   2: Evidence at transcript level;
KW   Amphibian defense peptide {ECO:0000256|ARBA:ARBA00022446};
KW   Antibiotic {ECO:0000256|ARBA:ARBA00023022};
KW   Antimicrobial {ECO:0000256|ARBA:ARBA00022529};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..78
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003262426"
FT   DOMAIN          3..38
FT                   /note="Frog antimicrobial peptide propeptide"
FT                   /evidence="ECO:0000259|Pfam:PF03032"
FT   DOMAIN          42..78
FT                   /note="Frog antimicrobial peptide brevinin-2/esculentin
FT                   type"
FT                   /evidence="ECO:0000259|Pfam:PF08023"
SQ   SEQUENCE   78 AA;  8473 MW;  F5068A0657D7C714 CRC64;
     MFTSKKSMLL FFFLGTISLS LCQEEERGAD EDEVVEEEVK RGLLSVFKGV LKTAGKNVAK
     NVAGSLLDQL KCKISGGC
//