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Entry: F1BN82_9NEOP
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ID   F1BN82_9NEOP            Unreviewed;       232 AA.
AC   F1BN82;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=Isocitrate dehydrogenase [NADP] cytoplasmic {ECO:0000256|ARBA:ARBA00040860};
DE   AltName: Full=Cytosolic NADP-isocitrate dehydrogenase {ECO:0000256|ARBA:ARBA00041229};
DE   AltName: Full=IDPc {ECO:0000256|ARBA:ARBA00041648};
DE   Flags: Fragment;
GN   Name=IDH {ECO:0000313|EMBL:ADX62439.1};
OS   Simplicia sp. RZ-2010.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Erebidae; Herminiinae; Simplicia.
OX   NCBI_TaxID=941453 {ECO:0000313|EMBL:ADX62439.1};
RN   [1] {ECO:0000313|EMBL:ADX62439.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zahiri R., Kitching I.J., Lafontaine J.D., Mutanen M., Kaila L.,
RA   Holloway J.D., Wahlberg N.;
RT   "A new molecular phylogeny offers hope for a stable family level
RT   classification of the Noctuoidea (Lepidoptera).";
RL   Zool. Scr. 40:158-173(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH;
CC         Xref=Rhea:RHEA:19629, ChEBI:CHEBI:15562, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:16810, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.42;
CC         Evidence={ECO:0000256|ARBA:ARBA00036496};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19630;
CC         Evidence={ECO:0000256|ARBA:ARBA00036496};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR   EMBL; HQ006520; ADX62439.1; -; Genomic_DNA.
DR   AlphaFoldDB; F1BN82; -.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006102; P:isocitrate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR004790; Isocitrate_DH_NADP.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   NCBIfam; TIGR00127; nadp_idh_euk; 1.
DR   PANTHER; PTHR11822:SF21; ISOCITRATE DEHYDROGENASE [NADP] CYTOPLASMIC; 1.
DR   PANTHER; PTHR11822; NADP-SPECIFIC ISOCITRATE DEHYDROGENASE; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE   3: Inferred from homology;
KW   Glyoxylate bypass {ECO:0000256|ARBA:ARBA00022435};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT   DOMAIN          2..232
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ADX62439.1"
FT   NON_TER         232
FT                   /evidence="ECO:0000313|EMBL:ADX62439.1"
SQ   SEQUENCE   232 AA;  26606 MW;  FF4CAE62E4E5B303 CRC64;
     NLIFPFLDIK LHVYDLGIEN RDKTEDQVTI DCAEAIKKYN VGIKCATITP DEQRVEEFKL
     KKMWKSPNGT IRNILGGTVF REAIICKNIP RLVTGWDKPI IIGRHAHADQ YKATDFVVPS
     AGTLEIIFKS TSGETIRHVV NEFKGAGVAI GMYNTDASII DFAHSSFKYA LDRNYPLYLS
     TKNTILKKYD GRFKDIFQEI YDKEYKSQYE AAGIWYEHRL IDDMVAYAMK SE
//
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