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Database: UniProt
Entry: F1C704_PERFV
LinkDB: F1C704_PERFV
Original site: F1C704_PERFV 
ID   F1C704_PERFV            Unreviewed;       298 AA.
AC   F1C704;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=Mitochondrial 2-oxoglutarate/malate carrier protein {ECO:0000256|ARBA:ARBA00040264};
DE   AltName: Full=Solute carrier family 25 member 11 {ECO:0000256|ARBA:ARBA00041881};
DE   Flags: Fragment;
GN   Name=Slc25a11 {ECO:0000313|EMBL:ADX97064.1};
OS   Perca flavescens (American yellow perch) (Morone flavescens).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Percoidei; Percidae; Percinae; Perca.
OX   NCBI_TaxID=8167 {ECO:0000313|EMBL:ADX97064.1};
RN   [1] {ECO:0000313|EMBL:ADX97064.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Pierron F., Normandeau E., Campbell P.G.C., Bernatchez L., Couture P.;
RT   "Effects of chronic metal exposure on wild fish populations revealed by
RT   high-throughput cDNA sequencing.";
RL   Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-
CC         oxoglutarate(in); Xref=Rhea:RHEA:71587, ChEBI:CHEBI:15589,
CC         ChEBI:CHEBI:16810; Evidence={ECO:0000256|ARBA:ARBA00036491};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate(out) + maleate(in) = 2-oxoglutarate(in) +
CC         maleate(out); Xref=Rhea:RHEA:71599, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:30780; Evidence={ECO:0000256|ARBA:ARBA00036076};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate(out) + malonate(in) = 2-oxoglutarate(in) +
CC         malonate(out); Xref=Rhea:RHEA:71591, ChEBI:CHEBI:15792,
CC         ChEBI:CHEBI:16810; Evidence={ECO:0000256|ARBA:ARBA00036366};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate(out) + oxaloacetate(in) = 2-oxoglutarate(in) +
CC         oxaloacetate(out); Xref=Rhea:RHEA:71603, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:16810; Evidence={ECO:0000256|ARBA:ARBA00036462};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate(out) + succinate(in) = 2-oxoglutarate(in) +
CC         succinate(out); Xref=Rhea:RHEA:71595, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:30031; Evidence={ECO:0000256|ARBA:ARBA00036084};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR   EMBL; HQ206466; ADX97064.1; -; mRNA.
DR   AlphaFoldDB; F1C704; -.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:InterPro.
DR   GO; GO:0006839; P:mitochondrial transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR   InterPro; IPR002030; Mit_uncoupling_UCP-like.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   PANTHER; PTHR45618:SF38; MITOCHONDRIAL 2-OXOGLUTARATE/MALATE CARRIER PROTEIN; 1.
DR   PANTHER; PTHR45618; MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00784; MTUNCOUPLING.
DR   SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Antiport {ECO:0000256|ARBA:ARBA00022449};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00282}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00282};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        109..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REPEAT          13..98
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          107..198
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          207..296
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   NON_TER         298
FT                   /evidence="ECO:0000313|EMBL:ADX97064.1"
SQ   SEQUENCE   298 AA;  32609 MW;  3DCCE60C16119E2E CRC64;
     MAETKPKTSP KAIKFLFGGL AGMGATVFVQ PLDLVKNRMQ LSGQGTKARE YKTSFHALFS
     ILKNEGVGGI YTGLSAGLLR QATYTTTRLG IYTILFEKMT GADGRPPNFL LKALIGMTAG
     AVGAFVGTPA EVALIRMTAD GRLPADQRRG YSNVFNALAR ITREEGVTTL WRGCIPTMAR
     AVVVNAAQLA SYSQTKQALL DSGYFGDDIL CHFCASMISG LVTTAASMPV DIVKTRIQNM
     KMIDGKPEYK NGVEVLMRVV RNEGFFSLWK GFTPYYARLG PHTVLTFIFL EQMNRLYK
//
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