ID F1KJF9_9HIV1 Unreviewed; 240 AA.
AC F1KJF9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ADY92374.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ADY92374.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ADY92374.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ADY92374.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=48clone22 {ECO:0000313|EMBL:ADY92374.1};
RX PubMed=21241214; DOI=10.1089/aid.2010.0346;
RA Persaud D., Bedri A., Ziemniak C., Moorthy A., Gudetta B., Abashawl A.,
RA Mengistu Y., Omer S.B., Isehak A., Kumbi S., Adamu R., Lulseged S.,
RA Ashworth R., Hassen E., Ruff And The Ethiopian Swen Study Team A.;
RT "Slower Clearance of Nevirapine Resistant Virus in Infants Failing Extended
RT Nevirapine Prophylaxis for Prevention of Mother-to-Child HIV
RT Transmission.";
RL AIDS Res. Hum. Retroviruses 27:823-829(2011).
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DR EMBL; JF336178; ADY92374.1; -; Genomic_DNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 41..231
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADY92374.1"
FT NON_TER 240
FT /evidence="ECO:0000313|EMBL:ADY92374.1"
SQ SEQUENCE 240 AA; 27861 MW; 53707F380B1C6D74 CRC64;
PIETVPVKLK PGMDGPKVKQ WPLSEEKIKA LTAICEEMEK EGKISKIGPE NPYNTPVFAI
KKKDSTKWRK LVDFRELNKR TQDFWEVQLG IPHPAGLKQK KSVTVLDVGD AYFSVPLDES
FRKYTAFTIP STNNETPGIR YQYNVLPQGW KGSPAIFQCS MTKILEPFRA QNPEIVIYQY
MDDLYVGSDL EIGQHREKIE ELREHLLKWG FTTPDKKHQK EPPFLWMGYE LHPDKWTVQP
//
