ID   F1KPS3_ASCSU            Unreviewed;       808 AA.
AC   F1KPS3;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Cullin-1 {ECO:0000313|EMBL:ADY39877.1};
OS   Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY39877.1};
RN   [1] {ECO:0000313|EMBL:ADY39877.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21685128; DOI=10.1101/gr.121426.111;
RA   Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA   Davis R.E.;
RT   "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT   functional diversification, and novel developmental profiles.";
RL   Genome Res. 21:1462-1477(2011).
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; JI163914; ADY39877.1; -; mRNA.
DR   AlphaFoldDB; F1KPS3; -.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF169; CULLIN-1; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   2: Evidence at transcript level;
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          448..676
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   808 AA;  93005 MW;  EFDE44E4A49BDA7B CRC64;
     MSSTNTRKRT LGEPERNGTR MGTRPAPSID EIWGDLEKGL NEIYSRQTMT PTRYMELYSR
     VYTYCTCVTY AGDQNRVGGA RTSRPSRTAR TNNSTAVGAE FVGLDLYNHV KHFFQTFVEN
     ILLNGGDLNG EDVLKYYTSE WDAYRFSSKV AGGIFSYLNR HWIKRELDEG NDNIYEIYAL
     ALVTWKEHLF VHMRHSVTSA VLKLIERERN GEKINTMLIS GVIQCYVELG VNETDTSIVA
     GPSSGSTTHS DRSPKLRVYR EYFEKRFLED TEAYFAHEAA EFIQANPVTE YMKKVETRLK
     EEKQRCDLYL NPSTQEVLAK TLEKVLISKQ LELFQNEFGN LLEANKDADL ERMYTLCDRV
     ENGLDELKAA LEKHIARQGE AALDKIADVA INDPKQYVST ILEVHKRYHQ LVTCAFKNEP
     GFVQSLDKAC TAFINRNNVT KKANSTTKSP ELLARYCDLL LKKSAKNPEE GEMEELLTQV
     MIVFKYIEDK DVFQKFYTKM LAKRLVNELS ASDEAESNMI SKLKQMCGFE YTSKLQRMFT
     DTSLSKDISE KYKQYLSSSN IELGLDFSIM VLGSGAWPFT QSSVFDIPRQ LDNCIEQFTK
     FYQAQHTGRK LTWLLSMCRG ELSTNAFQRK YTFTTTTAQM ALLMLYNDSL EMTMAQLQEN
     TKLKHEMLIQ IVHALVKVEL LSIVGQHVEV DMNTPLTTIL KLNLTFANKK LKVDLSKTMM
     RTEVRQETVE VQKSVDDDRR MVVQAAIVRI MKMRKRLKHT QLITEVLAQL SSRFKPKVPM
     IKKCVDVLID KEYLQRVEGE KDLYEYLA
//