ID   F1KQT4_ASCSU            Unreviewed;      1383 AA.
AC   F1KQT4;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   SubName: Full=Calcium-dependent secretion activator {ECO:0000313|EMBL:ADY40238.1};
OS   Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY40238.1};
RN   [1] {ECO:0000313|EMBL:ADY40238.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21685128; DOI=10.1101/gr.121426.111;
RA   Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA   Davis R.E.;
RT   "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT   functional diversification, and novel developmental profiles.";
RL   Genome Res. 21:1462-1477(2011).
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DR   EMBL; JI164364; ADY40238.1; -; mRNA.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:1990504; P:dense core granule exocytosis; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016079; P:synaptic vesicle exocytosis; IEA:InterPro.
DR   CDD; cd01234; PH_CADPS; 1.
DR   Gene3D; 1.10.357.50; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR033227; CAPS.
DR   InterPro; IPR010439; MUN_dom.
DR   InterPro; IPR014770; Munc13_1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR12166; CALCIUM-DEPENDENT SECRETION ACTIVATOR; 1.
DR   PANTHER; PTHR12166:SF8; CALCIUM-DEPENDENT SECRETION ACTIVATOR; 1.
DR   Pfam; PF06292; MUN; 2.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM01145; DUF1041; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS51258; MHD1; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Transport {ECO:0000256|ARBA:ARBA00022927}.
FT   DOMAIN          428..542
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          568..674
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          963..1094
FT                   /note="MHD1"
FT                   /evidence="ECO:0000259|PROSITE:PS51258"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          99..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..82
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1383 AA;  157385 MW;  ED3219576D91EA5C CRC64;
     MLGASSSEED DDDRFVNDND DTSEILSIPR QQLTTSVSPR SDSPAPSDSV SQANSLNRGD
     SARARRNDSA NSGLPTFRTS SSRQLHMAAV AGRPVFAQSS QDISDDDEDY TSNDQGTPAH
     VVADSAPKIS KEEQERIKAE LEEEQRKKKL QLYVFVAKCI AYHFNAKQPT DMARRQLKVN
     KQELARIKDR FQSFLKGETQ IAADEAFTKA IESYFEVFLK SERVQKVVQA GGFSQYDFRE
     VFRCNIEKRI RSLPEIDGLS KETVLNSWMT KFDTIIRGDE DTLQARQGRG RLRGVNQSSA
     DLILLKDQLY DMFQQILSVK KFEHQIIFNA LQLDNPDEQA AAIRREVATR EEALRDMSRM
     KKLMPKFVVK DMETLFIDET RQSINLLISN LESVPVTPRG QTVGGRKKDS KGRSSLKRRT
     SSSSLNKCDS DDDVSLTKSD VVLSFNLEVV VMEVQNLKSI SPNRIVYCTM EVDGCSKLQT
     DHAEASKPSW DTQGDFTTKH PLPTVKVKLY TEIRSIVAFE DKELGKVVIR PTPNCSRTPE
     WYKMTVPKNS TDQNLKIRIA IRVEKPPNLK YCGYCYAIGR IAWKKWKRRF FCLVQVSQYA
     FAICSYREKK ADPTEFIQLD GFTIDYMPEP DPELYNQGGK HFFTAIKEGD ELKFATDDEN
     ERHLWVQALY RATGQAYKPV PPKQSSVVPS KAQGFADKAS KHGMDELIQA EPLSFNHDHL
     FSELQSLTLD FRLNEPICSL GWFSPGQVFV LDEYCARYMV RGCHRYVSLL NDLLNKADEG
     HLIDPTLMHY SFAFCASHVH GNRPDGVGTV TLEEKERFQE VKERLRTLLE KQITNFRYCF
     PFGRPEGALK GTLSLLERVL MKDVVSPVPP EEVRNVIRKC LEDAALVNYT RICNEAKLER
     EVLRQERMGV DVSPQQRIED MIRVTEFCID LLKENEEHHG EAFAWFSDLL ADHSEIFWSL
     YSVDLDAALE VQPQDSWDSF PLFQLLNDFL CSEPTLKNGI FHTKLIQQFS PLVVRYIDLM
     EHSIAQSIDK GFAREKWELR KDGCATSEDI YWKLDALQGF VQDLNWPEEE FAKYLQVRMK
     ALASEMISKC ANCTYQCFDG FMQRARKSTD YVLPSEVCVM INVIFSSKSR ATKLTLDSGE
     YKYQSKLDET LETMLRDMET CIHDKLLAVL EYVLSKLARY DEGNPIGALL SIAPKPTSIF
     NRMKNIVGDQ GIAHLTGSTP SAPATPKPAA AQSQNSGHIG HSYVTFMRAC TEQLRQVVVD
     ELWVNALFEH WYDGQMKMIN EWLTERLQQS LSPYQLTCLL FIVKKIYSDF ELHGIDDERI
     NSKTYQSITR RLQLEEANCA LSENSAGTSS TSNHALIGNA TQAVSNMGSM VEGAGAKVFA
     LFK
//