ID F1KSR5_ASCSU Unreviewed; 786 AA.
AC F1KSR5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=ARF GTPase-activating protein GIT2 {ECO:0000313|EMBL:ADY40919.1};
OS Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY40919.1};
RN [1] {ECO:0000313|EMBL:ADY40919.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21685128; DOI=10.1101/gr.121426.111;
RA Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA Davis R.E.;
RT "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT functional diversification, and novel developmental profiles.";
RL Genome Res. 21:1462-1477(2011).
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DR EMBL; JI165263; ADY40919.1; -; mRNA.
DR AlphaFoldDB; F1KSR5; -.
DR EnsemblMetazoa; AgR005_g049_t01; AgR005_g049_t01; AgR005_g049.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd08833; ArfGap_GIT; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR047161; GIT-like.
DR InterPro; IPR032352; GIT1/2_CC.
DR InterPro; IPR022018; GIT1_C.
DR InterPro; IPR013724; GIT_SHD.
DR PANTHER; PTHR46097:SF3; ARF GTPASE-ACTIVATING PROTEIN GIT; 1.
DR PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF12205; GIT1_C; 1.
DR Pfam; PF16559; GIT_CC; 1.
DR Pfam; PF08518; GIT_SHD; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00555; GIT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 38..151
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 192..224
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 86771 MW; 6D052B64F09B4C9B CRC64;
MLIGRDGSSR EKKLPRPEMI SPTFTSTGAS SVRGPFQCAD CSADDPQWAS LNKGVLICSE
CCSVHRNLGR HISQVRSLKK GVWDSNQLEL MYVLYSNGSN NIWEHSLLDP QCSSKIKKKP
SPHDPVLPTK ENFIKAKYAD MAFMLRPAKD DAPITQEDLN RQLWSCVRTA HVETTLRLLV
LGADPNYMDP DKHCTPLHVA AKEGQALQVE LLWIYGGDVG QLNAGDLTPS QVARLENHVE
LAARLEELQF EVTNRLTMYL CGRRPDHSKQ QHFLIPELLG QGSDAVNLKV IRKQLRTVPA
PCFERIMQDV YDEVDRRETV AAWFATTQGT QPSHLGSDQC VAAFLPPNPQ LSAIRNQLRQ
KLAVCDAREL ATLIIDALCE AKRRYLGLPV EEDLDDSVED SPKKSSLTVD PINLSSVTAS
DRVTCPSDNR DYDEVAESPQ NKSRTSGSTK RSSDRKSDDS GNVLQENVIV SVDDFLELKE
KVFDSETKLN NVQQTNTHML RMLTGMQAKI DRISEENRGM HREIRKLKDS HSMALAKRQP
SPKTVLASGA SASNIPSSLG FDRQSVSSSK PPHEPSHIGC GYMSGRAASR GGCRHCGLTS
PPGGYASSVP RATSGLPPST RGPGAMHRNG SAPPLDHTGR GDSVEHIVKI ERDWAHDRSN
ERGEHLHRAL TQHIPTTFPD NLIAVTELLT QAIRELLLDA QNGVLPSHAA NHAQAIITLS
NRIWKTVPED RLTSQIEWCL TRMSDATVVL SAKCNAPLLS VDETCNAAYA VAKAAKQLLV
TVHWVF
//