ID   F1KT05_ASCSU            Unreviewed;       970 AA.
AC   F1KT05;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Macoilin {ECO:0000313|EMBL:ADY41009.1};
OS   Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY41009.1};
RN   [1] {ECO:0000313|EMBL:ADY41009.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21685128; DOI=10.1101/gr.121426.111;
RA   Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA   Davis R.E.;
RT   "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT   functional diversification, and novel developmental profiles.";
RL   Genome Res. 21:1462-1477(2011).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane
CC       {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004232}. Rough endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004269}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004269}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JI165378; ADY41009.1; -; mRNA.
DR   AlphaFoldDB; F1KT05; -.
DR   EnsemblMetazoa; AgR029_g113_t01; AgR029_g113_t01; AgR029_g113.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0023041; P:neuronal signal transduction; IEA:InterPro.
DR   InterPro; IPR019130; Macoilin.
DR   PANTHER; PTHR13289:SF6; MACOILIN; 1.
DR   PANTHER; PTHR13289; PROTEIN PHOSPHATASE 1-BINDING PROTEIN BIFOCAL; 1.
DR   Pfam; PF09726; Macoilin; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        44..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        81..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        106..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          334..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          441..496
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          614..823
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        334..379
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        455..482
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   970 AA;  105327 MW;  C92C9FF9752C79A7 CRC64;
     MMKRSTRSID VPKLRRNMKN RSRIAETMCC GYLSGFAYVK LLVLWLVCIA LDLLIGFRFE
     LLYPVWLLIR NCYDSFRFQG LVSSLQYSAF SAFFVCATAT TDLICFVLLP VQLLLFLAST
     YVWVQFVWHT AERGVGSTQV LLWVALVSFE YNCRYRGDSP LYLLRGTTFA WTLNVVTGGV
     LSSWLGLRDS PSSGGASESG GTVSARECSS RAFSSSSVLG GFGVALTAAF AHSSSLTSDL
     CRPFAAHCIG YPVVTLGFGL KTYMSLWRFK RRQREVSREN EVYGRLLVEA LPSIYEGPKV
     YPQCNTAAIQ DHESAIDYET ELLPSLAICA SPSSGSALSS QRKSSRAGSS WKQNGCKQIN
     AKRIPSHSNG SLLSSRKDQT NHNANDDDDT ASTASVSGTS RMSLWRLAWD VILMAFSLLT
     GGGGESASSS LDDRISLSSN EIESEEEMME QEETSSQPDD LPVASSRLLS QQRSNNAKKS
     KGSCTRVKGG RTRARNMHPQ SEYVLGSVPT GPSLSSPSLS ASCSLNNNLL NLTTGGTANE
     KQLYSPSSAL SPTNNYQNSG GSALGNSIFI GTTQSVAPIA NKVGDDYVTL EEVEALKGEL
     RAARCQETDL RYLLQQAINA EKQAKGELAQ LKMKHEQTDN KLSNLVKARE QDKCSMQLLE
     KRLIEAHAKK NELEKELNAE RRSKLKEEHA AARALAAAQS IKNVDCGEAC KARKADLERE
     IRATRRDLKA KEELTSVYEE QLRQLREFKD NNDLQELQST LASLRDKNHH LEQSLSAENR
     LKQDLFRVLT ETRSQTEMLQ QQLRAKDLEL MELRQRLSNE ANDTCKISPT GNSRGAVQAL
     NSSSGVRCGG PSGGGSLLSP VVNGAGGALK MSSSVNTEQN MELLTAALSS AASSAYLPYS
     FGGHGSGNEH LLFDATVSAG GPGVNAPSST PAPAISVTAN ASGSADSLRF SNTSKFCVPS
     APNSASVRST
//