ID   F1KU92_ASCSU            Unreviewed;       832 AA.
AC   F1KU92;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=valine--tRNA ligase {ECO:0000256|ARBA:ARBA00013169};
DE            EC=6.1.1.9 {ECO:0000256|ARBA:ARBA00013169};
DE   AltName: Full=Valyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00029936};
OS   Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY41446.1};
RN   [1] {ECO:0000313|EMBL:ADY41446.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21685128; DOI=10.1101/gr.121426.111;
RA   Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA   Davis R.E.;
RT   "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT   functional diversification, and novel developmental profiles.";
RL   Genome Res. 21:1462-1477(2011).
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR   EMBL; JI165970; ADY41446.1; -; mRNA.
DR   AlphaFoldDB; F1KU92; -.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004832; F:valine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006438; P:valyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd07962; Anticodon_Ia_Val; 1.
DR   CDD; cd00817; ValRS_core; 1.
DR   Gene3D; 3.40.50.620; HUPs; 2.
DR   Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR033705; Anticodon_Ia_Val.
DR   InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR   InterPro; IPR002303; Valyl-tRNA_ligase.
DR   NCBIfam; TIGR00422; valS; 1.
DR   PANTHER; PTHR11946:SF111; VALINE--TRNA LIGASE; 1.
DR   PANTHER; PTHR11946; VALYL-TRNA SYNTHETASES; 1.
DR   Pfam; PF08264; Anticodon_1; 1.
DR   Pfam; PF00133; tRNA-synt_1; 1.
DR   PRINTS; PR00986; TRNASYNTHVAL.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   2: Evidence at transcript level;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363035};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363035};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363035}.
FT   DOMAIN          58..657
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          703..807
FT                   /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT                   anticodon-binding"
FT                   /evidence="ECO:0000259|Pfam:PF08264"
SQ   SEQUENCE   832 AA;  94642 MW;  09660579C5D54ED0 CRC64;
     MRICPIRHRN VGTQVWNKTR TLSTVNGAKE GKSSFDVRAV TADYERRTEL AAKNRTGADG
     SRVFRMVLPP PNVTGKLHLG HALTVTVEDV ICRHKRIYGH HAIWHVGFDH AGIATQAVVE
     RHLWNESKLR RHHISREQFL QLCHQWKDTR ISEISNQLKR LGATLDWSNP YFTMDERFGR
     AVAIAFCRLY SEGLIFRERR LVNWCPTLQS TISDQEVDHI DVGQSKTISI PSLGSSKERS
     IKMGVMHHIR YELVEKHRSA EHLEVATTRP ETTFADVALA VHPQDARYFH LIGKAVRHPL
     IPNRIMPIIG DENVKPDKGT GVLKITPSHD FVDLNIARRH KEEIDDEAMN RCCIDEQGRL
     VNAPGFNGLD RFEARSKVID RLREIGAYGG ESSCSGGQIP MCSRTGDIVE PMMKEQWFLR
     CDEINDAILD AVNTAKLHIT PDFLRTKLEE WLSNKEPWCL SRQLLWGHRI PAYRIANSNK
     WIAATSDEDA RRIFGTEVKN SAGIMQDEDV LDTWFSSSLV PLVVAGWPEK RLNSSPLSLM
     ETGHDIVGFW VARMLTVCYR LSGCIPFTHV LLHGLVRDSA GRKMSKSLGN VIDPVDVIDG
     ISIDDMIGRL KESSLPDSEK EVASSNLRTM YPNGVTRCGP DALRFALLRY DLTALDINVN
     ISETALEGLR FCNKLWNLCA YAKSLWSKAQ SGTESRKSIH PADRWIKSCL SNSLQAMNMR
     IDEGNVHLAF ASIHKFILAD LCDVYLETTK KALWNNEEKR INEIAVVLRE VIEKSLIALS
     VFMPFVSEYL FEQIRTDNRL CIYDRYLVEN ELSSDVDNEL ERRNLNSQIK FT
//