ID F1KW64_ASCSU Unreviewed; 425 AA.
AC F1KW64;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 22-FEB-2023, entry version 24.
DE RecName: Full=Translocation protein SEC62 {ECO:0000256|ARBA:ARBA00021257};
OS Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY42118.1};
RN [1] {ECO:0000313|EMBL:ADY42118.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21685128; DOI=10.1101/gr.121426.111;
RA Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA Davis R.E.;
RT "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT functional diversification, and novel developmental profiles.";
RL Genome Res. 21:1462-1477(2011).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SEC62 family.
CC {ECO:0000256|ARBA:ARBA00010604}.
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DR EMBL; JI166892; ADY42118.1; -; mRNA.
DR AlphaFoldDB; F1KW64; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR004728; Sec62.
DR PANTHER; PTHR12443; TRANSLOCATION PROTEIN SEC62; 1.
DR PANTHER; PTHR12443:SF9; TRANSLOCATION PROTEIN SEC62; 1.
DR Pfam; PF03839; Sec62; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 206..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 103..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..378
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 425 AA; 48898 MW; 0D1F869B201E95AD CRC64;
MSDRRRGGRR KSNEATQKLS KEEDAIARFV RFNCPTKTTM FEGNEVHYFA GSKAVDILYE
SKKYGHNAKE VKFATRGAAV TFMRTLLEKG LFFRARKLVA KRKEDKKDGK EKDKGDVGKS
PKKKSKKEDQ LEKETEEERK GKKKEKAKDS DENDEEEEKE KKGRDKEDEE KKKRKVKLEL
HQDQSFNDSN DVYVWIFDPT PLFKKVIGAL MVLGTIAGCL FPLWPMWLRQ GVYYLSLVGL
GCFGLLIGVA IARTILFAII WATTMGRHRL WLLPNLTEDC GFFESFQPWY TYEYCPNGVS
ATGKKRKKPE DKKKSEEDSD KKTENEEDRK EEKEQRSEAE SSSDKTKSRR RKEERGDESA
ESEEGSASEA DEDEEESSQL QVSGISEEGS GEGGGDKKES EHATKVRQRR RARRTNDDFV
LVDKQ
//
