ID F1KYS4_ASCSU Unreviewed; 720 AA.
AC F1KYS4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 22-FEB-2023, entry version 42.
DE SubName: Full=Protein unc-112 {ECO:0000313|EMBL:ADY43028.1};
OS Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY43028.1};
RN [1] {ECO:0000313|EMBL:ADY43028.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21685128; DOI=10.1101/gr.121426.111;
RA Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA Davis R.E.;
RT "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT functional diversification, and novel developmental profiles.";
RL Genome Res. 21:1462-1477(2011).
CC -!- SIMILARITY: Belongs to the kindlin family.
CC {ECO:0000256|ARBA:ARBA00008052}.
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DR EMBL; JI168192; ADY43028.1; -; mRNA.
DR AlphaFoldDB; F1KYS4; -.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13205; FERM_C_fermitin; 1.
DR CDD; cd17095; FERM_F0_kindlins; 1.
DR CDD; cd01237; PH_fermitin; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR037843; Kindlin/fermitin.
DR InterPro; IPR040790; Kindlin_2_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037837; PH_Kindlin/fermitin.
DR PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR PANTHER; PTHR16160:SF13; FERMITIN 2-RELATED; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18124; Kindlin_2_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889}.
FT DOMAIN 403..508
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 150..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 81735 MW; 029ADFCE1EB6BE40 CRC64;
MAHLVENGVV NDGSWSLSVL VTDMNIQRTL FVTGQLHIGG LMLKLVDEID VTRDWSDHAL
WWPEKRKWLT HTRSTLDQMG ITADCSLEFT PQHKLARVQL PDLQMIDARL DFSVNVVKAT
QQLCREIGIR YSEELSLKRF IPPEMLRKGL GFESDQSGPQ PIRPGEESIG PGTLRRQTPI
SASACNLAGP LRRGTSPSLS TSGQMFNASE LGTLPRSGTL PRGVSPGPAA YSGTIGRTPM
MPSVSFCEGL ENEQYDMALV HSPRIVPNKE MTVFRPQNYI EKAALNRGWL DSSRSLMEQG
VFEGDVILLR FKFMTFFDMN PKYDPVRINQ LYEQAKWSIL LEEYDHTEEE AMLFAALQLQ
ATLQRNSPEP DPTERDDVDV LLDELEQNLD AAALSRRSDL TQVPELADYL KYMKPKKLAA
FKGFKRAYFS FRDLYLSWHQ NSNDISGPPL GHICLKGCEV NPDVSLAQSK FHIKLLIPSA
EGMSEFVLKC DTEHQYARWM AACRLASRGK SMADASYQSE VDSIKKLLQM QSGVTGSAQN
GTSKKKAPPV QLPPDFNVDE FVSQRYVRRA RSKQSLQQRI SDAHSNVRSL SSTEAKLQYI
RAWEALPEHG THYFVVRFRN GRKPELIGIA FNRIMKLNID SGESLKTWRF ATMKKWHVNW
EIRHLKIQFE NEDIEFKPLS ADCKVVHEFI GGYIFLSLRN KEQSQTLNEE LFHKLTGGWA
//
