ID F1L132_ASCSU Unreviewed; 661 AA.
AC F1L132;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Polyadenylate-binding protein {ECO:0000256|RuleBase:RU362004};
DE Short=PABP {ECO:0000256|RuleBase:RU362004};
DE Flags: Fragment;
OS Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY43836.1};
RN [1] {ECO:0000313|EMBL:ADY43836.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21685128; DOI=10.1101/gr.121426.111;
RA Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA Davis R.E.;
RT "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT functional diversification, and novel developmental profiles.";
RL Genome Res. 21:1462-1477(2011).
CC -!- FUNCTION: Binds the poly(A) tail of mRNA.
CC {ECO:0000256|RuleBase:RU362004}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU362004}.
CC -!- SIMILARITY: Belongs to the polyadenylate-binding protein type-1 family.
CC {ECO:0000256|ARBA:ARBA00008557, ECO:0000256|RuleBase:RU362004}.
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DR EMBL; JI169363; ADY43836.1; -; mRNA.
DR AlphaFoldDB; F1L132; -.
DR EnsemblMetazoa; AgB07_g035_t01; AgB07_g035_t01; AgB07_g035.
DR EnsemblMetazoa; AgB07_g035_t02; AgB07_g035_t02; AgB07_g035.
DR EnsemblMetazoa; AgB07_g035_t05; AgB07_g035_t05; AgB07_g035.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12378; RRM1_I_PABPs; 1.
DR CDD; cd12379; RRM2_I_PABPs; 1.
DR CDD; cd12380; RRM3_I_PABPs; 1.
DR CDD; cd12381; RRM4_I_PABPs; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR Gene3D; 1.10.1900.10; c-terminal domain of poly(a) binding protein; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR036053; PABP-dom.
DR InterPro; IPR006515; PABP_1234.
DR InterPro; IPR002004; PABP_HYD.
DR InterPro; IPR034364; PABP_RRM1.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR045305; RRM2_I_PABPs.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR NCBIfam; TIGR01628; PABP-1234; 1.
DR PANTHER; PTHR24012:SF915; POLYADENYLATE-BINDING PROTEIN; 1.
DR PANTHER; PTHR24012; RNA BINDING PROTEIN; 1.
DR Pfam; PF00658; PABP; 1.
DR Pfam; PF00076; RRM_1; 4.
DR SMART; SM00517; PolyA; 1.
DR SMART; SM00360; RRM; 4.
DR SMART; SM00361; RRM_1; 3.
DR SUPFAM; SSF63570; PABC (PABP) domain; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS51309; PABC; 1.
DR PROSITE; PS50102; RRM; 4.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|RuleBase:RU362004};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176,
KW ECO:0000256|RuleBase:RU362004}.
FT DOMAIN 19..97
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 107..184
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 200..279
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 305..382
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 580..658
FT /note="PABC"
FT /evidence="ECO:0000259|PROSITE:PS51309"
FT REGION 528..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 661
FT /evidence="ECO:0000313|EMBL:ADY43836.1"
SQ SEQUENCE 661 AA; 72484 MW; 8498AF447E111159 CRC64;
MAAAVATAGT GMTPSYPMAS LYVGDLHPDV TEAMLFEKFS SAGPVLSIRV CRDAITRRSL
GYAYVNFQQP ADAERALDTM NFDVMYGKPI RIMWSQRDPS MRRSGAGNIF IKNLDKSIDN
KAIYDTFSMF GNILSCKVAN DEESNSKGYG FVHFETEESA QKAIEKVNGM LLEGKKVYVG
KFQPRAARMR EMGETARRFT NVFIKNFADE LDKEKLEKLF AKFGKITSCA VMSDADGKSK
GFGFVAFENP EDAEKAVNEM HEYQLPDSER KLYVCRAQKK NERSAELKRR YEQQKVERMQ
RYQGVNLYVK NLDDTVDDEV LRQNFESYGK ITSAKVMCDD NGRSKGFGFV CFEKPDEATK
AVTEMNGKMM CTKPLYVALA QRKEDRKAQL ASQYMQRLAS IRMHNAGAMP GTMYTPGNGG
FFVSSALQNQ RAATFMPTAT IPGAQMRGSA PRWSAIGAAA AGFGVQSPYM VQSGGYGQAG
RGGARAATAG SAAAAMRAQG QYPGPAQAAT ARGPQAQRMA AGTIVQGQQT ARPQQLAGGR
QGQGAKPGQG QQMLYQSYGA MAARPGQVQQ QQSGIVVQGQ EPLTAHMLAQ ALPQEQKQML
GERIYPLIER IYQGPDVGKI TGMMLEMDNS ELLMMLENEE LLQSKVSEAA SVLASAKNEA
R
//
