ID   F1L5F2_ASCSU            Unreviewed;       460 AA.
AC   F1L5F2;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Protein disulfide-isomerase 2 {ECO:0000313|EMBL:ADY45356.1};
OS   Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY45356.1};
RN   [1] {ECO:0000313|EMBL:ADY45356.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21685128; DOI=10.1101/gr.121426.111;
RA   Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA   Davis R.E.;
RT   "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT   functional diversification, and novel developmental profiles.";
RL   Genome Res. 21:1462-1477(2011).
CC   -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC       {ECO:0000256|ARBA:ARBA00006347}.
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DR   EMBL; JI171714; ADY45356.1; -; mRNA.
DR   AlphaFoldDB; F1L5F2; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   CDD; cd02995; PDI_a_PDI_a'_C; 1.
DR   CDD; cd02982; PDI_b'_family; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 2.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR18929; PROTEIN DISULFIDE ISOMERASE; 1.
DR   PANTHER; PTHR18929:SF246; PROTEIN DISULFIDE-ISOMERASE; 1.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   Pfam; PF13848; Thioredoxin_6; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 2.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   2: Evidence at transcript level;
KW   Isomerase {ECO:0000313|EMBL:ADY45356.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        42..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          177..306
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   REGION          309..460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   460 AA;  53227 MW;  232C4C9B2B01EC07 CRC64;
     MPNKLSILKK RWACTLYWFV GTTTSFNVLT CTKFYFVYET RMAPVLIILL LTVTFAANIH
     AKGKPDPVTV FKRNTGKAIF TKDFPYYSVL IESKESEDYD DHFEEFEFAA KHFGDKVKFI
     FINTDVEENW ETIEYLGLIA EDVPTVLFID LTTGLSKYKA EFSEITRKNI ISFVQDCLDG
     KSVAFLKSED IPKNWDEKPL KQLVGKNFEK IVFEQKKTAF VLFYAPWCSA CQEALPEIEK
     LAELFADNKD VLIARMDATT NEVPRIPILD VPTLALFVKG DRKPIYYTDD ERTAEAFYKF
     ITTRMEKKES KKEEEVVQEE EKEADERHVG EKKKSERKTT KDEKETATKE KTERKTEKTE
     KKTEKAGKKT KTSAEDKMEP KEAKGKKSKK DTESKLEKDE KPKKEKEEKE KSKKKQADDA
     TQEKSTKSAK KTTTKKESDE KPKKDAKKSK GDKKSKKDEL
//