ID F1L6P1_ASCSU Unreviewed; 446 AA.
AC F1L6P1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Homeobox protein homothorax {ECO:0000313|EMBL:ADY45795.1};
OS Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX NCBI_TaxID=6253 {ECO:0000313|EMBL:ADY45795.1};
RN [1] {ECO:0000313|EMBL:ADY45795.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21685128; DOI=10.1101/gr.121426.111;
RA Wang J., Czech B., Crunk A., Wallace A., Mitreva M., Hannon G.J.,
RA Davis R.E.;
RT "Deep small RNA sequencing from the nematode Ascaris reveals conservation,
RT functional diversification, and novel developmental profiles.";
RL Genome Res. 21:1462-1477(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family.
CC {ECO:0000256|ARBA:ARBA00009661}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JI172507; ADY45795.1; -; mRNA.
DR AlphaFoldDB; F1L6P1; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR032453; PKNOX/Meis_N.
DR PANTHER; PTHR11850:SF102; HOMEOBOX PROTEIN HOMOTHORAX; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF16493; Meis_PKNOX_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 327..390
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 329..391
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 446 AA; 49714 MW; 185AC10F8FF35510 CRC64;
MKRSSMASVI SENKESRATV IEENELRNER IKKAALLHEA LSQAGAVRAQ KRKQKAMFSN
EAVECRGDER LHKECPAKEE CDEGAAENII ISERSAKQLI KHKSYISAIK EHFLFPLLEL
MLKKCEAATW SMSSEAFAMD DVVEMINEMS ATNEAMEFAN SELDALLFNM ILMLRIHLIE
LLKVADLCND FKTKYTQSLK KKINQESMIG SGGDSDEDMG PSTAITELPP QLSHNILTVP
QGANRTIAML ATANGMVSIP LSLWDTTSIH PSTFCASTAE ECCSSNCDKG ACTSDVLRTS
SDAHAKSVIE CSALQSYAAR TFSDEDTIDA RRKCLLPAKA VDTLKSWLFL HASHPYPSEE
QKALLSKETG LQMVQINNWF INARRRILPS KLDACSNDEI DATVRQIGEW NKGTKRLRRE
SKSNNHVHHS VTNLFVADDT SPKIER
//
