GenomeNet

Database: UniProt
Entry: F1LNF5_RAT
LinkDB: F1LNF5_RAT
Original site: F1LNF5_RAT 
ID   F1LNF5_RAT              Unreviewed;      1966 AA.
AC   F1LNF5;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 2.
DT   05-JUL-2017, entry version 52.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=Scn5a {ECO:0000313|Ensembl:ENSRNOP00000060586,
GN   ECO:0000313|RGD:3637};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000060586, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000060586, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000060586,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000060586}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000060586};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
RA   Lundby C., Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14
RT   different rat organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000060586}.
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DR   EMBL; AC094738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; F1LNF5; -.
DR   Ensembl; ENSRNOT00000066932; ENSRNOP00000060586; ENSRNOG00000015049.
DR   RGD; 3637; Scn5a.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Reactome; R-RNO-5576892; Phase 0 - rapid depolarisation.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000015049; -.
DR   ExpressionAtlas; F1LNF5; baseline and differential.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    128    150       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    254    274       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    389    417       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    719    737       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    749    770       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    782    799       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    839    862       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    919    942       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1154   1173       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1194   1210       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1222   1243       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1271   1297       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1393   1419       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1478   1496       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1508   1526       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1538   1558       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1595   1623       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1698   1721       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      131    423       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      479    668       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      719    946       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      956   1149       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1153   1428       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1477   1731       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      414    452       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1966 AA;  221687 MW;  9FDC88BEC7F1B4F5 CRC64;
     MANLLLPRGT SSFRRFTRES LAAIEKRMAE KQARGGSATS QESREGLQEE EAPRPQLDLQ
     ASKKLPDLYG NPPRELIGEP LEDLDPFYST QKTFIVLNKG KTIFRFSATN ALYVLSPFHP
     VRRAAVKILV HSLFSMLIMC TILTNCVFMA QHDPPPWTKY VEYTFTAIYT FESLVKILAR
     GFCLHAFTFL RDPWNWLDFS VIVMAYTTEF VDLGNVSALR TFRVLRALKT ISVISGLKTI
     VGALIQSVKK LADVMVLTVF CLSVFALIGL QLFMGNLRHK CVRNFTELNG TNGSVEADGL
     VWNSLDVYLN DPANYLLKNG TTDVLLCGNS SDAGTCPEGY RCLKAGENPD HGYTSFDSFA
     WAFLALFRLM TQDCWERLYQ QTLRSAGKIY MIFFMLVIFL GSFYLVNLIL AVVAMAYEEQ
     NQATIAETEE KEKRFQEAME MLKKEHEALT IRGVDTVSHS SLEMSPLAPV TNHERKSKRR
     KRLSSGTEDG GDDRLPKSDS EDGPRALNQL SLTHGLSRTS MRPRSSRGSI FTFRRRDQGS
     EADFADDENS TAGESESHRT SLLVPWPLRH PSAQGQPGPG ASAPGYVLNG KRNSTVDCNG
     VVSLLGAGDA EATSPGSYLL RPMVLDRPPD TTTPSEEPGG PQMLTPQAPC ADGFEEPGAR
     QRALSAVSVL TSALEELEES HRKCPPCWNR FAQHYLIWEC CPLWMSIKQK VKFVVMDPFA
     DLTITMCIVL NTLFMALEHY NMTAEFEEML QVGNLVFTGI FTAEMTFKII ALDPYYYFQQ
     GWNIFDSIIV ILSLMELGLS RMGNLSVLRS FRLLRVFKLA KSWPTLNTLI KIIGNSVGAL
     GNLTLVLAII VFIFAVVGMQ LFGKNYSELR HRISDSGLLP RWHMMDFFHA FLIIFRILCG
     EWIETMWDCM EVSGQSLCLL VFLLVMVIGN LVVLNLFLAL LLSSFSADNL TAPDEDGEMN
     NLQLALARIQ RGLRFVKRTT WDFCCGILRR RPKKPAALAT HSQLPSCITA PRSPPPPEVE
     KVPPARKETR FEEDKRPGQG TPGDSEPVCV PIAVAESDTE DQEEDEENSL GTEEESSKQT
     PEDSYSEGST ADMTNTADLL EQIPDLGEDV KDPEDCFTEG CVRRCPCCMV DTTQSPGKVW
     WRLRKTCYRI VEHSWFETFI IFMILLSSGA LAFEDIYLEE RKTIKVLLEY ADKMFTYVFV
     LEMLLKWVAY GFKKYFTNAW CWLDFLIVDV SLVSLVANTL GFAEMGPIKS LRTLRALRPL
     RALSRFEGMR VVVNALVGAI PSIMNVLLVC LIFWLIFSIM GVNLFAGKFG RCINQTEGDL
     PLNYTIVNNK SECESFNVTG ELYWTKVKVN FDNVGAGYLA LLQVATFKGW MDIMYAAVDS
     RGYEEQPQWE DNLYMYIYFV VFIIFGSFFT LNLFIGVIID NFNQQKKKLG GQDIFMTEEQ
     KKYYNAMKKL GSKKPQKPIP RPLNKYQGFI FDIVTKQAFD VTIMFLICLN MVTMMVETDD
     QSPEKVNILA KINLLFVAIF TGECIVKMAA LRHYYFTNSW NIFDFVVVIL SIVGTVLSDI
     IQKYFFSPTL FRVIRLARIG RILRLIRGAK GIRTLLFALM MSLPALFNIG LLLFLVMFIY
     SIFGMANFAY VKWEAGIDDM FNFQTFANSM LCLFQITTSA GWDGLLSPIL NTGPPYCDPN
     LPNSNGSRGN CGSPAVGILF FTTYIIISFL IVVNMYIAII LENFSVATEE STEPLSEDDF
     DMFYEIWEKF DPEATQFIEY LALSDFADAL SEPLRIAKPN QISLINMDLP MVSGDRIHCM
     DILFAFTKRV LGESGEMDAL KIQMEEKFMA ANPSKISYEP ITTTLRRKHE EVSATVIQRA
     FRRHLLQRSV KHASFLFRQQ AGGSGLSDED APEREGLIAY MMNGNFSRRS APLSSSSISS
     TSFPPSYDSV TRATSDNLPV RASDYSRSED LADFPPSPDR DRESIV
//
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