GenomeNet

Database: UniProt
Entry: F1LPJ2_RAT
LinkDB: F1LPJ2_RAT
Original site: F1LPJ2_RAT 
ID   F1LPJ2_RAT              Unreviewed;      4848 AA.
AC   F1LPJ2;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 3.
DT   05-JUL-2017, entry version 48.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSRNOP00000041223};
GN   Name=Ryr3 {ECO:0000313|Ensembl:ENSRNOP00000041223,
GN   ECO:0000313|RGD:68952};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000041223, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000041223, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000041223,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000041223}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000041223};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000041223}.
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DR   EMBL; AABR07053394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07053395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07053396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07053397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07053398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; F1LPJ2; -.
DR   PRIDE; F1LPJ2; -.
DR   Ensembl; ENSRNOT00000040306; ENSRNOP00000041223; ENSRNOG00000006645.
DR   RGD; 68952; Ryr3.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Reactome; R-RNO-2672351; Stimuli-sensing channels.
DR   Reactome; R-RNO-5578775; Ion homeostasis.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000006645; -.
DR   ExpressionAtlas; F1LPJ2; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IDA:RGD.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IDA:RGD.
DR   GO; GO:0051481; P:negative regulation of cytosolic calcium ion concentration; IDA:RGD.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 7.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4165   4189       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4389   4409       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4457   4476       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4588   4606       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4649   4670       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4729   4752       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       83    138       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      145    190       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      198    252       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      258    316       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      326    383       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      568    781       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1009   1191       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1237   1449       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3898   3933       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4848 AA;  550247 MW;  7C38863BB39927F6 CRC64;
     EDEVVLQCIA NIHKEQRKFC LAAEGLGNRL CFLEPTSEAK YIPPDLCVCN FVLEQSLSVR
     ALQEMLANTV ENGGEGAAQG GSHRTLLYGH AILLRHSFSG MYLTCLTTSR SQTDKLAFDV
     GLREHATGEA CWWTIHPASK QRSEGEKVRI GDDLILVSVS SERYLHLSIS NGSIQVDASF
     MQTLWNVHPT CSGSSIEEGY LLGGHVVRLF HGHDECLTIP STDQNDSQHR RVFYEAGGAG
     TRARSLWRVE PLRISWSGSN IRWGQALRLR HLTTGHYLAL TEDQGLLLQD RGKADTKSTA
     FSFRASKEIK EKLDSSHKRD MEGMGVPEIK YGDSVCFVQH VASGLWVTYK AQDAKTSRLG
     PLKRKVILHQ EGHMDDGLTL QRCQQEESQA ARIIRNTTAL FSQFVSGNNR TAAPVALPIE
     EVLQTLQDLI AYFQPPEEDM QHEDKQNKLR SLKNRQNLFK EEGMLALVLN CIDRLNIYNS
     VAHFAGIIRE ENGMAWKEIL NLLYKLLAAL IRGNRNNCAQ FSNNLDWLIS KLDRLESSSG
     ILEVLHCILI ESPEALNLIA EGHIKSIISL LDKHGRNHKV LDVLCSLCLC NGVAVRANQN
     LICDNLLPRR NLLLQTRLIN DVTSIRPNIF LGVAEGSPQY KKWYFELIID QVEPFLTAEP
     THLRVGWASS SGYAPYPGGG EGWGGNGVGD DLYSYGFDGL HLWSGRIPRA VASINQHLLK
     SDDVVSCCLD LGVPSISFRI NGQPVQGMFE NFNTDGLFFP VMSFSAGVKT HFVAKLRHVE
     KKFLASSLHV PCISSLLPQE RKKERKKERK KERKKERKIL LCSQFYSNAV TVPTPVKSYQ
     VVLPLHLEKI RDRLAENIHE LWGMNKIELG WTFGKVRDDN KRQHPCLVEF SKLPETEKNY
     NLQMSTETLK TLLALGCHIA HVNPAAEEDL KKVKLPKNYM MSNGYKPAPL DLSDVKLLPP
     QEILVDKLAE NAHNVWAKDR IKQGWTYGIQ QDLKNKRNPR LVPYALLDER TKKSNRDSLR
     EAVRTFVGYG YNIEPSDQEL VADPTVEKVS IDKIRFFRVE RSYAVKSGKW YFEFEVVTGG
     DMRVGWARPG CRPDIELGAD DQAFVFEGSR GQRWHQGSGY FGRTWQPGDV VGCMINLDDA
     SMVFTLNGEL LITNKGSELA FADYEIENGF VPICSLGLSQ IGRMNLGTDA STFKFYTMCG
     LQEGFEPFAV NMNRDVAVWF SKRLPTFVNV PKDHPHIEVV RIDGTMDSPP CLKVTHKTFG
     TQNSNANMIY CRLSMPVECH SSFSHSPCLD SEAFQKRKQM QEILSHTTTQ CYYAIRIFAG
     QDPSCVWVGW VTPDYHLYSE KFDLNKNCTV TVTLGDERGR VHESVKRSNC YMVWGGDIVA
     SSQRSSRSNV DLEIGCLLDL AMGMLSFSAN GKELGTCYQV EPNTKVFPAV FLQPTSTSLF
     QFELGKLKNA MPLSAAIFKS EEKNPIPQCP PRLDVQTIQP VLWSRMPSSF LKVETERVSE
     RHGWVVQCLE PLQMMALHIP EENRCVDILE LCEQEDLMQF HYHTLRLYSA VCALGNSRVA
     SALCSHVDLS QLFYAIDNKY LPGLLRSGFY DLLISIHLAN AKERKLMMKN EYIIPITSST
     RNIRLYPDES KRHGLPGVGL RTCLKPGFRF STPCFVVTNE DHQKQSPEIP LQILKTKALS
     MLTEAVHCSG AHIRDPVGGS VEFQFVPVLK LIGTLLVMGV FDDDDVRQIL LLIDPSVFGE
     HSGETEEGVE KEVTHVEEKA VEAGEKASKE APVKGLLQTR LPESVKLQMC ELLSYLCDCE
     LQHRVEAIVA FGDIYVSKLQ ANQKFRYNEL MQALNMSAAL TARKTREFRS PPQEQINMLL
     NFHLGENCPC PEEIREELYD FHEDLLVHCG VPLEEEEEEE EDTSWTGKLC ALVYKIKGQP
     KPEKEPPTEE EEPYPTTLKE LVSQTMIRWA QENQIQDAEL VRMMFNLLRR QYDSIGELLQ
     ALRKTYTISQ ASVNDTINLL AALGQIRSLL SVRMGREEEL LMINGLGKIE QAEVFYPHPN
     LMRSPSVACM RTVMKMMVKV FGAKRSKIAF PKMVASCCRF LCYFCRISRQ NQKAMFEHLS
     YLLENSSVGL ASPSMRGSTH WMWQPPSVMD NNELALGLEE PDLEKVVTYL AGCGLQSCPM
     LLAKGYPDIG WNPIEGERYL SFLRFAVFVN SESVEENASV VVKLLIRRPE CFGPALRGEG
     GNGLLAAMQG AIKISESPAL DLPSQGYKTE VTQDDEEEEE IVHMGNAIMS FYSALIDLLG
     RCAPEMHLIQ TGKGEAIRIR SILRSLVPTE DLVGIISIPL KLPSLNKDGS VSEPDMAANF
     CPDHKAPMVL FLDRVYGIKD QTFLLHLLEV GFLPDLRASA SLDTVSLSTT EAALALNRYL
     CSAVLPLLTR CAPLFSGTEH CTSLIDSTLQ TIYRLSKGRS LTKAQRDTIE ECLLAICNHL
     RPSMLQQLLR RLVFDVPQLS EYCKMPLKLL TNHYEQCWKY YCLPSGWGSY GLAVEEELHL
     TEKLFWGIFD SLSHKKYDPD LFRMALPCLS AIAGALPPDY LDTRITATLE KQVSVDADGN
     FDPKPINTMN FSLPEKLEYI VTKYAEHSHD KWACDKSHSG WKYGISLDEN VKTHPLIRPF
     KTLTEKEKEI YRWPARESLK TMLAVGWTVE RTKEGEALVQ QRENEKLRCV SQSNQGNSYS
     PAPLDLSNVV LSRELQGMVE VVAENYHNIW AKKKKLELES KGGGSHPLLV PYDTLTAKEK
     LRDREKAQDL FKFLQVNGIL VSRGVKDMEL DASSMEKRFA YKFLRKILKY VDSAQEFIAH
     LEAIVSSGKT EKSPHDQEIK FFAKVLLPLV DQYFTNHRLY FLSSPLKPLS SSGYASHKEK
     EMVASLFCKL AALVRHRISL FGSDSTTMVS CLHILAQTLD TRTVMKSGSE LVKAGLRAFF
     ENAAEDLEKT SENLKLGKFT HSRTQIKGVS QNINYTTVAL LPILTSIFEH IAQHQFGVDL
     LLSDVQISCY HILCSLYSLG TGKNIYVERQ RPALGECLAS LAAAIPVAFL EPSLNRYNPL
     SVFNTKTPRE RSILGMPDKV EDMCPDVPQL EGLMKEINGL AESGARYTEM PHVIEVILPM
     LCNYLSYWWE RGPENLPPSI GPCCTKVTSE HLSLILGNIL KIINNNLGID EASWMKRIAV
     YAQPIISKAR PDLLRSHFIP TLEKLKKKAV KIVQEEEQLK TDGKGDTQEA ELLILDEFAV
     LCRDLYAFYP MLIRYVDNNR SNWLKSPDTD SDQLFRMVAE VFILWCKSHN FKREEQNFVI
     QNEINNLAFL TGDSKSKMSK SGGQDQERKK TKRRGDLYSI QTSLIVAALK KMLPIGLNMC
     TPGDQELISL AKSRYSCRDT DEEVKEHLRN NLHLQEKSDD PAVKWQLNLY KDVLRNEEPS
     NPEKTVERVQ RISAALFHLE QVEQPLRSKK AVWHKLLSKQ RKRAVVACFR MAPLYNLPRH
     RSINLFLHGY QRFWIETEAY SFEEKLVQDL AKSPRVEDEE EEETEKQPDP LHQIILHFSR
     NALTERSKLE DDPLYTSYSS MMAKSCQSGE DEEEEEDKEK TFEEKEMEKQ KTLYQQARLH
     ERGAAEMVLQ MISASKGEMS PMVVETLKLG IAILNGGNAG VQQKMLDYLK EKKDAGFFQS
     LSGLMQSCRS VLDLNAFERQ NKAEGLGMVT EEGTLIVRER GEKVLQNDEF TQDLFRFLQL
     LCEGHNSDFQ NFLRTQMGNT TTVNIIISTV DYLLRLQESI SDFYWYYSGK DIIDESGQHN
     FSKALAVTKQ IFNSLTEYIQ GPCIGNQQSL AHSRLWDAVV GFLHVFANMQ MKLSQDSSQI
     ELLKELLDLL QDMVVMLLSL LEGNVVNGTI GKQMVDTLVE SSTNVEMILK FFDMFLKLKD
     LTSSDTFKEY DPDGKGIISR KEFQKAMEGL KQYTQSEIDF LLSCTEADEN DMFNYVDFVE
     RFHEPAKDIG FNVAVLLTNL SEHMPNDSRL KCLLDPAESV LNYFEPYLGR IEIMGGAKKI
     ERVYFEISES SRTQWEKPQV KESKRQFIFD VVNEGGEQEK MELFVNFCED TIFEMQLASQ
     ISESDSTDRP EEEEEEDEDS YSVEIEGEEE DKSFESASAF AMACASAKRN VTKFLKKATL
     KNLRKQYRNV KKMSAKELVR VLSSFFWMLV VGLFQLLFSI LGGIFHILWN TVFGGGLVEG
     AKNIRVTKIL GDMPDPTQFG IHDDVMEIDR AEVTEPGITT ELVHFVKGEA GDTDVMSDLF
     GIHSKKEGGS KQGPEVGLGD LSEITGKDEP PTLESTVRKK RKAQAAEMKA VHEAEGRTES
     EKADMEDREK EDKIKEEGQA EYLWADTTVK KTRRRGQKAE KPVAFMANFF KGLEIYQTKL
     LHYLARNFYN LRFLALFVAF AINFILLFYK VTEEPLEEET EDVANLWNSF NEDDEEEAMV
     FFVLQESTGY MAPTLRALAI VHTVISLVCV VGYYCLKVPL VVFKREKEIA RKLEFDGLYI
     TEQPSEDDIK GQWDRLVINT PSFPNNYWDK FVKRKVINKY GDLYGAERIA ELLGLDKNAL
     DFSPVEEAKA EAASLVSWLS SIDMKYHIWK LGVVFTDNSF LYLAWYTTMS VLGHYNNFFF
     AAHLLDIAMG FKTLRTILSS VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF RKFYNKSEDD
     DEPDMKCDDM MTCYLFHMYV GVRAGGGIGD EIEDPAGDPY EMYRIVFDIT FFFFVIVILL
     AIIQGLIIDA FGELRDQQEQ VREDMETKCF ICGIGNDYFD TTPHGFETHT LQEHNLANYL
     FFLMYLINKD ETEHTGQESY VWKMYQERCW DFFPAGDCFR KQYEDQLG
//
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