ID F1LQT4_RAT Unreviewed; 565 AA.
AC F1LQT4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Carboxypeptidase N subunit 2 {ECO:0000313|Ensembl:ENSRNOP00000049568.2};
GN Name=Cpn2 {ECO:0000313|Ensembl:ENSRNOP00000049568.2,
GN ECO:0000313|RGD:1305170};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000049568.2, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000049568.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000049568.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000049568.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000049568.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1LQT4; -.
DR SMR; F1LQT4; -.
DR STRING; 10116.ENSRNOP00000049568; -.
DR PaxDb; 10116-ENSRNOP00000049568; -.
DR Ensembl; ENSRNOT00000048746.4; ENSRNOP00000049568.2; ENSRNOG00000024384.6.
DR UCSC; RGD:1305170; rat.
DR AGR; RGD:1305170; -.
DR RGD; 1305170; Cpn2.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000163072; -.
DR HOGENOM; CLU_000288_18_6_1; -.
DR InParanoid; F1LQT4; -.
DR OMA; REVFCSD; -.
DR TreeFam; TF351124; -.
DR Reactome; R-RNO-977606; Regulation of Complement cascade.
DR Proteomes; UP000002494; Chromosome 11.
DR Bgee; ENSRNOG00000024384; Expressed in liver.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24373:SF271; CARBOXYPEPTIDASE N SUBUNIT 2; 1.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01462; LRRNT; 1.
DR SMART; SM00364; LRR_BAC; 10.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 4.
PE 1: Evidence at protein level;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1LQT4};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..44
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 45..565
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003269096"
FT DOMAIN 44..76
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
FT DOMAIN 418..469
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
SQ SEQUENCE 565 AA; 62640 MW; 0C79AD5EFDD3EFD4 CRC64;
MKFSSVSEEK PGLLAPPAQP LTKMFQGAWL CWASLLLLVR VTQPCPVGCD CFDRKIFCSD
EQLAAIPLDI PSHVTDIVFV ETSFTTVGTR AFSGSPNLTK VVFLNTRVHH LEPDAFGGLP
RLEDLEVTGS PFSNLSANIF SNLSSLGKLT LDFNRLAALP EDLFHHMDTL ESLQLQGNQL
QTLPGRLFQS LRYLRTLNLA QNLLTQLPKG MFQSLSSLQI LKLSDNMFAR LPEGVLSNLG
SLQELFLDSN AITELSPHLF SHLLSLEKLW LQHNAISLLP VSAFSSLRNL TFLNLKDNAL
RTLPAGLFTH NPGLLHLSLS YNQLETVPEG SFANLRKLAS LTLSHNAITH LPENVFRNLE
QLVKLSLDSN NLTVLHPTLF HNLSKLQLLD LSRNQLTMLP GGIFDTNYDL FNLALLGNPW
QCDCRLSYLT SWLRLYNDRI FNTHTFCAGP AYLKGQLVPN LKQEQLVCPG NPGQLGLDDR
EPAGSWDLAV EGRAAHRQCI YGNPEGTVLL ACEEAQCRWL NIQLSSREGS DVTAMAYNSS
QEWELRSTCG SVRVTVSIEA QAAGP
//
