GenomeNet

Database: UniProt
Entry: F1LS89_RAT
LinkDB: F1LS89_RAT
Original site: F1LS89_RAT 
ID   F1LS89_RAT              Unreviewed;      4938 AA.
AC   F1LS89;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 3.
DT   05-JUL-2017, entry version 51.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSRNOP00000059019};
GN   Name=Ryr2 {ECO:0000313|Ensembl:ENSRNOP00000059019,
GN   ECO:0000313|RGD:620314};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000059019, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000059019, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000059019,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000059019}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000059019};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
RA   Lundby C., Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14
RT   different rat organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000059019}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AABR07028327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07028328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07028329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07028330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07028331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07028332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07028333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07028334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07028335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07028336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; F1LS89; -.
DR   PRIDE; F1LS89; -.
DR   Ensembl; ENSRNOT00000067949; ENSRNOP00000059019; ENSRNOG00000017060.
DR   RGD; 620314; Ryr2.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Reactome; R-RNO-2672351; Stimuli-sensing channels.
DR   Reactome; R-RNO-5578775; Ion homeostasis.
DR   Proteomes; UP000002494; Chromosome 17.
DR   Bgee; ENSRNOG00000017060; -.
DR   ExpressionAtlas; F1LS89; baseline and differential.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4251   4270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4470   4490       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4545   4564       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4677   4696       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4739   4760       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4815   4838       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       87    142       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      149    194       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      202    257       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      263    320       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      328    385       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      576    786       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1002   1199       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1334   1540       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3994   4029       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4938 AA;  561284 MW;  1C8612E0182003D4 CRC64;
     DDEVVLQCTA TIHKEQQKLC LAAEGFGNRL CFLESTSNSK NVPPDLSICT FVLEQSLSVR
     ALQEMLANTV EKSEGKTNMK TAQGGGHRTL LYGHAILLRH SYSGMYLCCL STSRSSTDKL
     AFDVGLQEDT TGEACWWTIH PASKQRSEGE KVRVGDDLIL VSVSSERYLH LSYGNSSWRV
     DAAFQQTLWS VAPISSGSEA AQGYLIGGDV LRLLHGHMDE CLTVPSGEHG EEQRRTVHYE
     GGAVSVHARS LWRLETLRVA WSGSHIRWGQ PFRLRHVTTG KYLSLMEDKN LLLMDKEKAD
     VKSTAFAFRS SKEKLDAGVR KEVDGMGTSE IKYGDSICYI QHVDTGLWLT YQAVDVKSAR
     MGSIQRKAIM HHEGHMDDGL NLSRSQHEES RTARVIRSTV FLFNRFIRGL DALSKRAKLP
     TVDLPIESVS LSLQDLIGYF HPPDEHLEHE DKQNRLRALK NRQNLFQEEG MINLVLECID
     RLHVYSSAAH FADVAGREAG ESWKSILNSL YELLAALIRG NRKNCAQFSG SLDWLISRLE
     RLEASSGILE VLHCVLVESP EALNIIKEGH IKSIISLLDK HGRNHKVLDV LCSLCVCHGV
     AVRSNQHLIC DNLLPGRDLL LQTRLVNHVS SMRPNIFLGV SEGSAQYKKW YYELMVDHTE
     PFVTAEATHL RVGWASTEGY SPYPGGGEEW GGNGVGDDLF SYGFDGLHLW SGCIARTVSS
     PNQHLLRTDD VISCCLDLSA PSISFRINGQ PVQGMFENFN IDGLFFPVVS FSAGIKVRFL
     LGGRHGEFKF LPPPGYAACY EAVLPKEKLK VEHSREYKQE RTYTRDLLGP TVSLTQAAFT
     PVPVDTSQIV LPPHLERIRE RLAENIHELW VMNKIELGWQ YGPVRDDNKR QHPCLVEFCK
     LPEQERNYNL QMSLETLKTL LALGCHVGIA DEHAEEKVKK MKLPKNYQLT SGYKPAPMDL
     SFIKLTPSQE AMVDKLAENA HNVWARDRIR QGWTYGIQQD VKNRRNPRLV PYTLLDDRTK
     KSNKDSLREA VRTLLGYGYH LEAPDQDHAS RAEVCSGTGE RFRIFRAEKT YAVKAGRWYF
     EFEAVTAGDM RVGWSRPGCQ PDLELGSDER AFAFDGFKAQ RWHQGNEHYG RSWQAGDVVG
     CMVDMNEHTM MFTLNGEILL DDSGSELAFK DFDVGDGFIP VCSLGVAQVG RMNFGKDVST
     LKYFTICGLQ EGYEPFAVNT NRDITMWLSK RLPQFLQVPS NHEHIEVTRI DGTIDSSPCL
     KVTQKSFGSQ NSNTDIMFYR LSMPIECAEV FSKSVAGGIP GAGFYGPKND LEDFDVDSDF
     EVLMKTAHGH LVPDRMDKDK ETPKPEFNNH KDYAQEKPSR LKQRFLLRRT KPDYSTSHSA
     RLTEDVLADD RDDYEYLMQT STYYYSVRIF PGQEPANVWV GWITSDFHQY DTGFDLDRVR
     TVTVTLGDEK GKVHESIKRS NCYMVCAGES MSPGQGRNNS NGLEIGCVVD AASGLLTFIA
     NGKELSTYYQ VEPSTKLFPA VFAQATSPNV FQFELGRIKN VMPLSAGLFK SEHKNPVPQC
     PPRLHVQFLS HVLWSRMPNQ FLKVDVSRIS ERQGWLVQCL DPLQFMSLHI PEENRSVDIL
     ELTEQEELLQ FHYHTLRLYS AVCALGNHRV AHALCSHVDE PQLLYAIENK YMPGLLRAGY
     YDLLIDIHLS SYATARLMMN NEFIVPMTEE TKSITLFPDE NKKHGLPGIG LSTSLRPRMC
     FSSPSFVSIS NECYQYSPEF PLDILKAKTI QMLTEAVKEG SLHARDPVGG TTEFLFVPLI
     KLFYTLLIMG IFHNEDLKHI LQLIEPSVFK EAATPEEEGG APEKEISIDD SKLEVKEEAK
     AGKRPKEGLL QMKLPEPVKL QMCLLLQYLC DCQVRHRIEA IVAFSDDFVA KLQDNQRFRY
     NEVMQALNMS AALTARKTKE FRSPPQEQIN MLLNFKDDKS ECPCPEEIRD QLLDFHEDLM
     THCGIELDED GSLDGSNDLT IRGRLLSLVE KVTYLKKKQA EKPVASDSRK SSSLQQLISE
     TMVRWAQESV IEDPELVRAM FVLLHRQYDG IGGLVRALPK TYTINGVSVE DTINLLASLG
     QIRSLLSVRM GKEEEKLMIR GLGDIMNNKV FYQHPNLMRA LGMHETVMEV MVNVLGGGES
     KEITFPKMVA NCCRFLCYFC RISRQNQKAM FDHLSYLLEN SSVGLASPAM RGSTPLDVAA
     ASVMDNNELA LALREPDLEK VVRYLAGCGL QSCQMLVSKG YPDIGWNPVE GERYLDFLRF
     AVFCNGESVE ENANVVVRLL IRRPECFGPA LRGEGGNGLL AAMEEAIKIA EDPSRDGPSP
     TSGSSKTLDA EEEEDDTIHM GNAIMTFYAA LIDLLGRCAP EMHLIHAGKG EAIRIRSILR
     SLIPLGDLVG VISIAFQMPT IAKDGKVVEP DMSAGFCPDH KAAMVLFLDR VYGIEVQDFL
     LHLLEVGFLP DLRAAASLDT AALSATDMAL ALNRYLCTAV LPLLTRCAPL FAGTEHHASL
     IDSLLHTVYR LSKGCSLTKA QRDSIEVCLL SICGQLRPSM MQHLLRRLVF DVPLLNEHAK
     MPLKLLTNHY ERCWKYYCLP GGWSNFGAAS EEELHLSRKL FWGIFDALSQ KKYEQELFKL
     ALPCLSAVAG ALPPDYMESN YVSMMEKQSS MDSEGNFNPQ PVDTSNITIP EKLEYFINKY
     AEHSHDKWSM DKLANGWIYG EIYSDSSKIQ PLMKPYKLLS EKEKEIYRWP IKESLKTMLA
     WGWRIERTRE GDSMALYNRT RRISQTSQVS IDAAHGYSPR AIDMSNVTLS RDLHAMAEMM
     AENYHNIWAK KKKMELESKG GGNHPLLVPY DTLTAKEKAK DREKAQDIFK FLQISGYAVS
     RGFKDLDLDT PSIEKRFAYS FLQQLIRYVD EAHQYILEFD GGSRSKGEHF PYEQEIKFFA
     KVVLPLIDQY FKNHRLYFLS AASRPLCTGG HASNKEKEMV TSLFCKLGVL VRHRISLFGN
     DATSIVNCLH ILGQTLDART VMKTGLDSVK SALRAFLDNA AEDLEKTMEN LKQGQFTHTR
     SQPKGVTQII NYTTVALLPM LSSLFEHIGQ HQFGEDLILE DVQVSCYRIL TSLYALGTSK
     IYVERQRSAL GECLAAFAGA FPIAFLETHL DKHNVYSIYN TRSSRERAAL SLPANVEDVC
     PNIPSLEKLM TEIIELAESG IRYTQMPHMM EVVLPMLCSY MSRWWEHGPE NHPERAEMCC
     TALNSEHMNT LLGNILKIIY NNLGIDEGAW MKRLAVFSQP IINKVKPQLL KTHFLPLMEK
     LKKKAAMVVS EEDHLKAEAR GDMSEAELLI LDEFTTLARD LYAFYPLLIR FVDYNRAKWL
     KEPNPEAEEL FRMVAEVFIY WSKSHNFKRE EQNFVVQNEI NNMSFLITDT KSKMSKAAIS
     DQERKKMKRK GDRYSMQTSL IVAALKRLLP IGLNICAPGD QELIALAKNR FSLKDTEEEV
     RDVIRSNIHL QGKLEDPAIR WQMALYKDLP NRAEDTSDPE RTVERVLDIA NVLFHLEQVE
     HPQRSKKAVW HKLLSKQRKR AVVACFRMAP LYNLPRHRAV NLFLQGYEKS WIETEEHYFE
     DKLIEDLAKP GSELPEEDEA MKRVDPLHQL ILLFSRTALT EKCKLEEDFL YMAYADIMAK
     SCHDEEDDDG EEEVKSFEVT GSQRSKEKEM EKQKLLYQQA RLHDRGAAEM VLQTFSASKG
     ETGPMVAATL KLGIAILNGG NSTVQQKMLD YLKEKKDVGF FQSLAGLMQS CSVLDLNAFE
     RQNKAEGLGM VTEEGSGEKV LQDDEFTCDL FRFLQLLCEG HNSDFQNYLR TQTGNNTTVN
     IIISTVDYLL RVQESISDFY WYYSGKDIID EQGQRNFSKA IQVAKQVFNT LTEYIQGPCT
     GNQQSLAHSR LWDAVVGFLH VFAHMQMKLS QDSSQIELLK ELMDLQKDMV VMLLSMLEGN
     VVNGTIGKQM VDMLVESSNN VEMILKFFDM FLKLKDLTSS DTFKEYDPDG KGVISKRDFH
     KAMESHKHYT QSETEFLLSC AETDENETLD YEEFVKRFHE PAKDIGFNVA VLLTNLSEHM
     PNDTRLQTFL ELAESVLNYF QPFLGRIEIM GSAKRIERVY FEISESSRTQ WEKPQVKESK
     RQFIFDVVNE GGEKEKMELF VNFCEDTIFE MQLAAQISES DLNERSANKE ESEKERPEEQ
     APRMGFFSLL TVQSALFALR YNVLTLVRML SLKSLKKQMK RMKKMTVKDM VSAFFSSYWS
     VFVTLLHFVA SVCRGFFRIV SSLLLGGSLV EGAKKIKVAE LLANMPDPTQ DEVRGDEEEG
     ERKPLESALP SEDLTDLKEL TEESDLLSDI FGLDLKREGG QYKLIPHNPN AGLSDLMTNP
     IPVPEVQEKF QEQKVKEEKE GKEETKSEPE KAEGEDGEKE EKAKDDKGKQ KLRQLHTHRY
     GEPEVPESAF WKKIIAYQQK LLNYFARNFY NMRMLALFVA FAINFILLFY KVSTSSVVEG
     KELPTRTSSD AAKVTTSLDS SPHRIIAVHY VLEESSGYME PTLRILAILH TIISFFCIIG
     YYCLKVPLVI FKREKEVARK LEFDGLYITE QPSEDDIKGQ WDRLVINTQS FPNNYWDKFV
     KRKVMDKYGE FYGRDRISEL LGMDKAALDF SDAREKKKPK KDSSLSAVCD QLDIYHFLWK
     LGVVFSSNSF LYLAWYMTMS VLGHYNNFFF AAHLLDIAMG FKTLRTILSS VTHNGKQLVL
     TVGLLAVVVY LYTVVAFNFF RKFYNKSEDG DTPDMKCDDM LTCYMFHMYV GVRAGGGIGD
     EIEDPAGDEY EIYRIIFDIT FFFFVIVILL AIIQGLIIDA FGELRDQQEQ VKEDMETKCF
     ICGIGNDYFD TVPHGFETHT LQEHNLANYL FFLMYLINKD ETEHTGQESY VWKMYQERCW
     EFFPAGDCFR KQYEDQLN
//
DBGET integrated database retrieval system