ID F1LYI0_RAT Unreviewed; 1465 AA.
AC F1LYI0;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=CECR2, histone acetyl-lysine reader {ECO:0000313|Ensembl:ENSRNOP00000015499.6};
GN Name=Cecr2 {ECO:0000313|Ensembl:ENSRNOP00000015499.6,
GN ECO:0000313|RGD:1564182};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000015499.6, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000015499.6, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000015499.6,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000015499.6}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000015499.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008761473.1; XM_008763251.2.
DR AlphaFoldDB; F1LYI0; -.
DR STRING; 10116.ENSRNOP00000015499; -.
DR PaxDb; 10116-ENSRNOP00000015499; -.
DR Ensembl; ENSRNOT00000015499.7; ENSRNOP00000015499.6; ENSRNOG00000011566.8.
DR GeneID; 500308; -.
DR AGR; RGD:1564182; -.
DR CTD; 27443; -.
DR RGD; 1564182; Cecr2.
DR VEuPathDB; HostDB:ENSRNOG00000011566; -.
DR eggNOG; KOG1472; Eukaryota.
DR GeneTree; ENSGT00940000160360; -.
DR HOGENOM; CLU_006327_0_0_1; -.
DR InParanoid; F1LYI0; -.
DR OMA; HQGMRYP; -.
DR OrthoDB; 5403278at2759; -.
DR TreeFam; TF324727; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000011566; Expressed in skeletal muscle tissue and 16 other cell types or tissues.
DR GO; GO:0090537; C:CERF complex; ISO:RGD.
DR GO; GO:0000791; C:euchromatin; ISO:RGD.
DR GO; GO:0031010; C:ISWI-type complex; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; ISO:RGD.
DR GO; GO:0006338; P:chromatin remodeling; ISO:RGD.
DR GO; GO:0090102; P:cochlea development; ISO:RGD.
DR GO; GO:0097194; P:execution phase of apoptosis; ISO:RGD.
DR GO; GO:0060122; P:inner ear receptor cell stereocilium organization; ISO:RGD.
DR GO; GO:0001842; P:neural fold formation; ISO:RGD.
DR GO; GO:0001843; P:neural tube closure; ISO:RGD.
DR GO; GO:0021915; P:neural tube development; ISO:RGD.
DR GO; GO:0007338; P:single fertilization; ISO:RGD.
DR CDD; cd05509; Bromo_gcn5_like; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR029614; CECR2.
DR PANTHER; PTHR47092; CAT EYE SYNDROME CRITICAL REGION PROTEIN 2; 1.
DR PANTHER; PTHR47092:SF1; CAT EYE SYNDROME CRITICAL REGION PROTEIN 2; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 431..501
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 170..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 977..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1055..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1268..1295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1410..1465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 323..378
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 220..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..860
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..914
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1006
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1027
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1274..1295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1465 AA; 162448 MW; 2F9DE9475F59C118 CRC64;
MCPEEGGAAG LGELRSWWEV PAIAHFCSLF RTAFRLPDFE IEELEAALHR DDVDFISDLI
ACLLQGCYQR RDITPQTFHS YLEDIINYRW ELEEGKPNPL REASFQDLPL RTRVEILHRL
CDYRLDADDV FDLLKGLDAD SLRVEPLGED NSGALYWYFY GTRMYKEDPV QGRSNGELSL
SRESERQKNV SNVPGKTGKR RGRPPKRKKL QEEIISSEKQ EENSLTSDLQ TRNGSRGPGQ
GTWWLLCQTE EEWRQVTESF RERTSLRERQ LYKLLSEDFL PEICNMIAQK GKRPQRTKPE
LQHRFMSDHL SIKSTKLEET PMLTKIEKQK RKEEEEERQL LLAVQKKEQE QMLKEERKRE
LEEKVKAVED RAKRRKLREE RAWLLAQGKE LPPELSHLDL NSPMREGKKT KDIFELDDDF
TAMYKVLDVV KAHKDSWPFL EPVDESYAPN YYQIIKIPMD ISSMEKKLNG GLYCTKEEFV
NDMKTMFRNC RKYNGDSSEY TKMSENLERC FHRAMTKHFP GEDGDTDEEF WIREDEKREK
RRSRAGRSSG SHVWTRSRDT EGSSRKQPPM ENGGKSLPPA RRAASSGDDQ SSSSIQLPPE
VGTSNGRGFF HPLHYSRVPS QAPPLNQMRP AASGTFGSLQ GSDPTNLHGS SRIPEVPPGE
PLQHPPFAIQ APVGISNHRG SRLSAPEEKM CGGLTHLSNM GSHVPSLQLG QMNCNSQDGN
IYPPAPFQAG FIPSRHGGTP ARPPDFPESS EIPPSHIYHS YKYLNRVHPA VWNGNHGTTN
PGRLGPDEKP LVGPGASHHP HALGHMMDGR VMRQPIPPNQ WTKQSSFLPP GVPSSGYMQP
PCKSAGHRLQ PPPTPAPSPR FRGPSQALRG AQGGESMMDS PEMIAMQQLS SRVCPPGVPY
HPRQPTPPQL PGPFPQVAHS ASVCVSAPKP ALDNPGSTQE ISETQEPEGD RAEPVPGLEE
KAASICSSEG LYLKQLPHPA PPLSASCTRQ SSPHERETED SQLKSDASDS ADTYKASKNK
NPWPLDNSYN SAAVQGALHG GRDLAIVTER GNLPENGVVG EASPCRSEGK GLGGSGSEKP
LCPRGKTLQE TVPCTGQNAT TPPCTDPNLM AGTVNQFSPL YMPGIEYSNS ATHYPMSPSL
QGLGSMMGAK SPGSQPQSFS PRSFQANGPH PGLFPRYRPQ QGMRYSYQPS SQPSYHPYQR
TPYYTCPQGF SDWQRSLPSQ RSPSGPPGSH PPRPLFSDKN ALTSLQGCET LNAALTSPTQ
MDAVAAKVVP PDGHNSGPEE EKMDESMERP ESPKEFLDLD NHNAATKRQS SLSTNDYLYG
APPPPLSSGM TFGSSAFPPH SVMLQTGSPY TPQRSASHFQ PRAYASPVPA HPPPHPVATQ
PNGLSPEGPL YCCQEEGLGH FQAAMMEQTG TGSGIRGSFQ DAHRPPGLQM HPIQSQSLFP
KTPAPAASPE QLPPHKAPTL PLDQS
//