GenomeNet

Database: UniProt
Entry: F1M7G0_RAT
LinkDB: F1M7G0_RAT
Original site: F1M7G0_RAT 
ID   F1M7G0_RAT              Unreviewed;      2027 AA.
AC   F1M7G0;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 3.
DT   22-NOV-2017, entry version 45.
DE   SubName: Full=Transient receptor potential cation channel, subfamily M, member 6 {ECO:0000313|Ensembl:ENSRNOP00000017892};
GN   Name=Trpm6 {ECO:0000313|Ensembl:ENSRNOP00000017892,
GN   ECO:0000313|RGD:1309942};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000017892, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000017892, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000017892,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000017892}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000017892};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSRNOP00000017892}.
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DR   EMBL; AABR07006452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10116.ENSRNOP00000017892; -.
DR   PaxDb; F1M7G0; -.
DR   Ensembl; ENSRNOT00000017892; ENSRNOP00000017892; ENSRNOG00000013053.
DR   UCSC; RGD:1309942; rat.
DR   RGD; 1309942; Trpm6.
DR   eggNOG; ENOG410KCTA; Eukaryota.
DR   eggNOG; ENOG410ZSH9; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   InParanoid; F1M7G0; -.
DR   OMA; NERMAMK; -.
DR   OrthoDB; EOG091G0DHL; -.
DR   TreeFam; TF314204; -.
DR   Reactome; R-RNO-3295583; TRP channels.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000013053; -.
DR   GO; GO:0016324; C:apical plasma membrane; ISO:RGD.
DR   GO; GO:0031526; C:brush border membrane; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005261; F:cation channel activity; ISO:RGD.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0030001; P:metal ion transport; ISO:RGD.
DR   GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR   GO; GO:0009636; P:response to toxic substance; ISO:RGD.
DR   Gene3D; 1.20.5.1010; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR004166; MHCK_EF2_kinase.
DR   InterPro; IPR029597; TRPM6.
DR   InterPro; IPR032415; TRPM_tetra.
DR   InterPro; IPR037162; TRPM_tetra_sf.
DR   PANTHER; PTHR13800:SF15; PTHR13800:SF15; 1.
DR   Pfam; PF02816; Alpha_kinase; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF16519; TRPM_tetra; 1.
DR   SMART; SM00811; Alpha_kinase; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51158; ALPHA_KINASE; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    750    768       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    848    867       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    915    933       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    945    964       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    984   1004       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1057   1080       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1755   1985       Alpha-type protein kinase.
FT                                {ECO:0000259|PROSITE:PS51158}.
SQ   SEQUENCE   2027 AA;  232126 MW;  5FF5B32200F76C2A CRC64;
     LLLKKSWIER VFYKRECNKF IPSSKDPHRC TPGCQICQNL VRCYCGRLIQ EHQGLDRAWS
     LSATEGNGNE QWSVEKHTVK SPTDTFGTIN FQDGEHIYHS KYIRTSWDTK SDHLLHLMLK
     EWNMELPKLV ISVHGGLQNF KMPSKLKETF SQGLVKAAET TGAWIITEGI NSGVSKHVGD
     ALKAHSSMSL RKIWTVGIPP WGVIENQREL VGKDVVCMYQ TLSNPLSKLT TLNCMHSHFI
     LCDDGTVGKY GNEEKLRRNL EKHLSMQKIH TCSRQGVPVV GLVVEGGPNV ILWVWETVRN
     KEPVVVCEGT GRAADLLAFT YKHSEDGGIL RPQVKEEILC LIQNMFNFSL RQSKHLFQIL
     MECMVHKDSI TIFDADSEEH QDLDLAILKA LLKGTSLSIS EQLNLAMAWD RMDIAKKHIL
     IYGQHWKPGA LEQAMRDALV MDRVDFVKLL IENGVNLHRF LTISRLEDLY NTKQGPTNKF
     LRHLVQDVKQ HTLLSSYRIT LIDIGLVIEY LIGGAYRSSY TRKSFRVLYN DLYRKHKGMT
     SFAQGLSQHP LHQRHSLGNR KESSESTLHS QFFRTAQPYK SKDKPEDSHK PKKKSKERHS
     LSEDPGSAGF IYPYNDLLVW AVLMKRQKMA MFFWQHGEEA TVKAVIASIL YRAMAREAKE
     SNMVDDTSEE LKKYSEQFGQ LALDVLEKAF KQNEPMAMKL LTYELKNWSN STCLKLAVSG
     GLRPFVSHSC TQMLLTDMWM GRLKMRKNSW LKIIISILLP PMILTLEFKS KAEMSHVPQS
     QDFQFTWNYS DQGLSNTKEA ACLKDYDLER GPDEKLDEAL HLDLRNVPQS LPWTRRVYEF
     YSAPFVKFWF YTMAYLAFLM LFTYTVLVEM QPQPSVQEWL VIIYIFTNAI EKVREICISE
     PSKFTQKVKM WLSEYWNLME TVAIGLFAVG FGLRWGHPPL HTAGRLIYCI DIIFWFSRLL
     DFFAVNQHAG PYVTMIAKMA ANMFYIVIIM AIVLLSFGVA RKAILSPKEP PSWRLARDIV
     FEPYWMMYGE VYASEIDVCS NETSCPPGSF LTPFLQAVYL FVQYIIMVNL LIACFNTLYL
     ESQTMNVKLW QTKRARFDRA YGQRLWCPEP SLLLSHLCTT PQNIVCFSSP QEKEEGDRGR
     KLYLTKDDLK KLHDFEEQCV EKYFHEKTEG LNCSCEEQIR ATSERVSEMF FQLKEMNEKV
     SFIKDSLLSL DSQVGHLQDL SALTVDTLKV LSAVDTLQED EILLANRKHS TCRKRPHSWT
     NVICAKVLTD MESCGKQKFQ YYSMPPSLLR SLARSQLPPG VQRGALVEVT HNTREASHVR
     EDQKEREVEQ RTIASGVSHV RQAHSKYGQF LLVPPSEKQV SLSLENPPHL FRASGETGTD
     DVALQHRHPS DVTIHLPGQT PAVSHQALGA EHKDQHEAVI QMSGKPDKAE QDSLKFSGTP
     APMAVTSLPS RAISMQDEGG YVNWAFSESD EAGVFSFKKK WKTCLASTCD SGSKPGGDCS
     LQAAGRSGLD NSRLAQSCEW PAGPWTQARR SFWINPLCRD KPLLKSHSFR FHKEEKLRKT
     WKNNSHSKAS ETGSTWLKAK LLTKNRSLSK KRRKAQGLQV PVITVNACYQ SDQLTSESGE
     TNTTEDYSKN WLSVSNFSQI GLEPYIYQKM KMKEIERHTT QASYHLRQMQ EDPDKNPSWN
     SRSASVSRSF LTRSPNEVDK ISASLKSPPE PHRHYSAIER NNLMRLSQTI PFTPIQLFTG
     EEVTIYKLEE TSPLTLDKSM SSWSQHGRAA IIQVLSQEEM DGGLRKAMRV ISTWSEDDVL
     KPGQVFIVKS FLPEVVQTWY KIFQESTVLH LCLREIQQQR AAQKLIYTFN QVKPQTIPYT
     PRFLEVSLVY CHSANQWLTI EKYMTGEFRK YNNNNGDEIA PTNTLEELML AFSHWTYEYT
     RGELLVLDLQ GVGENLTDPS VIKPEDKQSR GMVFGPANLG EDAIRSFIAK HRCNSCCGKL
     RLPDLKRNDY SHARAHCNLE LAKTTEPAEE HPERDRNRSP LEDHTRL
//
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