ID F1MCU5_BOVIN Unreviewed; 765 AA.
AC F1MCU5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Chondroadherin like {ECO:0000313|Ensembl:ENSBTAP00000050251.3};
GN Name=CHADL {ECO:0000313|Ensembl:ENSBTAP00000050251.3,
GN ECO:0000313|VGNC:VGNC:27265};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000050251.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000050251.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000050251.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000050251.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000050251.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|PIRNR:PIRNR037595}.
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DR AlphaFoldDB; F1MCU5; -.
DR PaxDb; 9913-ENSBTAP00000050251; -.
DR Ensembl; ENSBTAT00000055322.3; ENSBTAP00000050251.3; ENSBTAG00000040106.3.
DR VEuPathDB; HostDB:ENSBTAG00000040106; -.
DR VGNC; VGNC:27265; CHADL.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000154464; -.
DR HOGENOM; CLU_022061_0_0_1; -.
DR TreeFam; TF337463; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000040106; Expressed in laryngeal cartilage and 31 other cell types or tissues.
DR ExpressionAtlas; F1MCU5; baseline.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR017241; Toll-like_receptor.
DR PANTHER; PTHR24373:SF373; CHONDROADHERIN-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR Pfam; PF13855; LRR_8; 5.
DR PIRSF; PIRSF037595; Toll-like_receptor; 6.
DR SMART; SM00364; LRR_BAC; 6.
DR SMART; SM00369; LRR_TYP; 18.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00013; LRRNT; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 2.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|PIRNR:PIRNR037595};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..765
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018595052"
FT DOMAIN 28..62
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
FT DOMAIN 306..354
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT DOMAIN 388..422
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
FT DOMAIN 668..716
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 349..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 765 AA; 82378 MW; 84F2A70651D9B004 CRC64;
AEPQSLSLVL LLPLLLPLGP NRCAVAQRCP QACVCDNPRR HVACRHQNLT EVPTAIPELT
QRLDLQGNML KEIPPAAFRD LPHLTHLDLR RCQVELVAEG AFRGLGRLLL LNLASNRLRA
LPQEALDGLG SLQRLELAGN LLEELRPGTF GALGAVTTLN LAHNALVYLP AMAFQGLVRA
RWLQLSHNAL SVLAPEALAG LPALRRLSLH HNELQALPGA ALSQARGLAR LELGHNPFTY
TGEEDGLALP GLRELRLDHG ALQALDARAF ARCPRLHTLD LRGNQLDALP PLQGPGQLRR
LRLQGNPLWC GCRARPLLEW LARARVRSDG ACWGPRRLRG EALDALRPSD LRCPRPGAEE
EEEAEELKAA RPRAPGDAPG EEAGAAGPCP RTCVCVPESR HSSCEGRGLQ AVPRGFPNDT
QLLDLRRNRF PVVPQAAFPG LGRLVSLHLQ HCGLTELEAG ALAGLDSLIY LYLSDNRLSG
LSAAALEGAP RLGYLYLERN RFVRMPGAAL LALPSLFSLH LQDNALDHLA PGDLAGGRAL
RWLYLSGNRL ARVSPGALGP ARELEKLHLD RNQLGEVPTE ALEGLPALLE LQLSGNPLGA
LRDGAFRPVG RSLQHLFLNS SGLEQISPGA FSGLGPRLRS LHLQKNQLQT LPALPGLGEL
ELVDLSGNPF HCDCQLLPLH RWLAGLNLRV GATCATPPSA RGQRVKAAAA VFEACPGQAA
RKAKRTPAPR PGAWGTPTKG RRQRANKVGR GVVGSGFKAL MVVGV
//
