ID F1MFU5_BOVIN Unreviewed; 694 AA.
AC F1MFU5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=RNA polymerase II-associated protein 3 {ECO:0000256|ARBA:ARBA00040133};
GN Name=RPAP3 {ECO:0000313|Ensembl:ENSBTAP00000048352.3,
GN ECO:0000313|VGNC:VGNC:34100};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000048352.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000048352.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000048352.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000048352.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000048352.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RPAP3 family.
CC {ECO:0000256|ARBA:ARBA00038275}.
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DR AlphaFoldDB; F1MFU5; -.
DR SMR; F1MFU5; -.
DR STRING; 9913.ENSBTAP00000048352; -.
DR PaxDb; 9913-ENSBTAP00000024878; -.
DR Ensembl; ENSBTAT00000054570.3; ENSBTAP00000048352.3; ENSBTAG00000018690.6.
DR VEuPathDB; HostDB:ENSBTAG00000018690; -.
DR VGNC; VGNC:34100; RPAP3.
DR GeneTree; ENSGT00940000156749; -.
DR HOGENOM; CLU_1239755_0_0_1; -.
DR InParanoid; F1MFU5; -.
DR OMA; NFTPDRP; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000018690; Expressed in spermatocyte and 107 other cell types or tissues.
DR ExpressionAtlas; F1MFU5; baseline and differential.
DR GO; GO:0101031; C:protein folding chaperone complex; IBA:GO_Central.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR025986; RPAP3-like_C.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46423; RNA POLYMERASE II-ASSOCIATED PROTEIN 3; 1.
DR PANTHER; PTHR46423:SF1; RNA POLYMERASE II-ASSOCIATED PROTEIN 3; 1.
DR Pfam; PF13877; RPAP3_C; 1.
DR Pfam; PF00515; TPR_1; 2.
DR Pfam; PF13432; TPR_16; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..694
FT /note="RNA polymerase II-associated protein 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018755558"
FT REPEAT 162..195
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 230..263
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 311..344
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 379..412
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 575..665
FT /note="RNA-polymerase II-associated protein 3-like C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF13877"
FT REGION 70..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 43..70
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 286..316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 694 AA; 78864 MW; 1E545BCA80ACA9F7 CRC64;
MRAVRVLVRL RCYLLCAGGD WSVKTLHAVM ASTSKAIELQ LQVKQNAEEL QDFMRDLENW
EKDIKQKDME LRRQNGVPEE NLPPIRNGNF RKKKKGKVKE SSKKTKDENA KNRIKSYDYE
AWAKLDVDSI LDELDKEEST HDSVSQESES EEDGIHVDSQ KALALKEKGN KYFKQGKYDE
AIECYTKGMD ADPYNPVLPT NRASAYFRLK KFAVAESDCN LAIALNRSYT KAYARRGAAR
FALQKLEDAK KDYEKVLELE PNNFEATNEL RKINQALTSK EDSYPGETDT MVKSDEGEKK
QIEEQQNKQQ AVSEKDRGNA FFKEGKYERA IECYTRGIAA DGANALLPAN RAMAYLKIQK
YEEAEKDCTQ AVLLDGSYSK AFARRGTART FLGKLSEAKQ DFETVLLLEP GNKQAVTELS
KIKKELIEKG HWDDVFLDST QRQNVIKPID NLPHLGSTKP LKKVIIEETG NLIQTVDVRD
STATVAAAEC NPVTLASVTA TTGMTNKNTS QDDLLPTSDV PKAKVLKIEE ISDTSALHSH
VNLKKDVCQS LSEKIPTEVD KAPAQFIRTV LPPVPANSFQ LESDFRQLKS SPDMLYQYLK
QIEPSLYPKL FQKNLDPDVF NQIIKILHDF YIEKEKPSLI FEILQRLSEL RRFDMAVMFM
SESEKKITRV LFNHIDKSGL NDNSVEELKK RYGG
//
