ID F1MFZ5_BOVIN Unreviewed; 929 AA.
AC F1MFZ5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Protein unc-45 homolog B {ECO:0000256|ARBA:ARBA00020768};
GN Name=UNC45B {ECO:0000313|Ensembl:ENSBTAP00000003766.5,
GN ECO:0000313|VGNC:VGNC:36668};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000003766.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000003766.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000003766.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000003766.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000003766.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, A band
CC {ECO:0000256|ARBA:ARBA00004161}. Cytoplasm, myofibril, sarcomere, Z
CC line {ECO:0000256|ARBA:ARBA00004216}. Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}.
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DR RefSeq; XP_002695676.1; XM_002695630.4.
DR RefSeq; XP_615458.3; XM_615458.6.
DR AlphaFoldDB; F1MFZ5; -.
DR SMR; F1MFZ5; -.
DR STRING; 9913.ENSBTAP00000003766; -.
DR PaxDb; 9913-ENSBTAP00000003766; -.
DR Ensembl; ENSBTAT00000003766.5; ENSBTAP00000003766.5; ENSBTAG00000002898.5.
DR GeneID; 535385; -.
DR KEGG; bta:535385; -.
DR CTD; 146862; -.
DR VEuPathDB; HostDB:ENSBTAG00000002898; -.
DR VGNC; VGNC:36668; UNC45B.
DR eggNOG; KOG4151; Eukaryota.
DR GeneTree; ENSGT00940000157654; -.
DR HOGENOM; CLU_007331_0_0_1; -.
DR InParanoid; F1MFZ5; -.
DR OMA; YEQATST; -.
DR OrthoDB; 1094381at2759; -.
DR TreeFam; TF314096; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000002898; Expressed in infraspinatus muscle and 44 other cell types or tissues.
DR GO; GO:0031672; C:A band; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR GO; GO:0051879; F:Hsp90 protein binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0061077; P:chaperone-mediated protein folding; IBA:GO_Central.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR024660; UCS_central_dom.
DR PANTHER; PTHR45994; FI21225P1; 1.
DR PANTHER; PTHR45994:SF2; PROTEIN UNC-45 HOMOLOG B; 1.
DR Pfam; PF11701; UNC45-central; 1.
DR SMART; SM00185; ARM; 4.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Myogenesis {ECO:0000256|ARBA:ARBA00022541};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 6..39
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 309..489
FT /note="UNC-45/Cro1/She4 central"
FT /evidence="ECO:0000259|Pfam:PF11701"
SQ SEQUENCE 929 AA; 103325 MW; D73B457947161187 CRC64;
MAEAEAMQLK EEGNQHFQLQ DYKAATKSYS QALKLTKDKA LLATLYRNRA ACGLKMESYV
QAASDASRAI DINSSDIKAL YRRCQALEHL GKLDQAFKDV QRCATLEPQN QSFQETLRRL
NTSIQEKLRV QFSTDSRVQT MFEILLDRNS EADKLEKAAN NLIVLSREEA GAERIFQNNG
VALLMQLLDT KRPELMLAAV RTLSGVCSSH RARATATLHA VRIDRICSLM AVESEEMSLA
VCNLLQGIID ALSGEDKQEH RGKEEALVLD SKKDLKQITN HLLDMLVSKK VSGQGRDQAL
NLLNKNVPRK DLAIHDNSRT IYVVDNGLRK ILKVVGQVPD LPSCLPLTDN TRMLASILIN
KLYDDLRCDP ERDHFRKICE EHITGTFDPQ DMDKNVIAIQ TVSGILQGPF DLGNQLLGLK
GVMEMMVALC GSERETDQLV AVEALIHAST KLSRATFIIT NGVSLLKEIY KTTKNEKIKI
RALVGLCKLG SAGGTDYALR QFAEGSTEKL AKQCRKWLCN ASIDTRTRKW AVEGLAYLTL
DADVKDDFVQ DIPALQAMFE LAKTPDKTIL YSVATTLVNC TNSYDVKEVI PELVQLAKFS
KQHVPEEHPK DKKDFVDMRV KRLLKAGVTS ALVCMVKADN AILTDQTKEL LARVFLALCD
NPKDRGTIVA QGGGKALIPL ALEGTDVGKV KAAHALAKIA AVSNPDIAFP GERVYEVVRP
LVSLLNTQRD GLQNYEALLG LTNLSGRSDK LRKKIFKEKA LPDIENYMFE NHDQLRQAAT
ECMCNMVVNK EVQERFLADG NDRLKLVVLL CGEDDDKLQN AAAGALAMLT AAHKKLCFKM
TEVTTQWLEI LQRLCLHDRL SVQHRGLVIA YNLLAADAEL AKKLVESELL EILTVVGKQE
PDEKRAAVVQ TARECLIKCM DYGFIKPVA
//
