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Database: UniProt
Entry: F1MH43_BOVIN
LinkDB: F1MH43_BOVIN
Original site: F1MH43_BOVIN 
ID   F1MH43_BOVIN            Unreviewed;       832 AA.
AC   F1MH43;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   25-OCT-2017, entry version 40.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A1 {ECO:0000313|Ensembl:ENSBTAP00000043461};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000043461, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000043461, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000043461,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000043461}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000043461};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000043461}.
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DR   EMBL; DAAA02049190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; F1MH43; -.
DR   Ensembl; ENSBTAT00000046135; ENSBTAP00000043461; ENSBTAG00000019218.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   Reactome; R-BTA-1222556; ROS, RNS production in phagocytes.
DR   Reactome; R-BTA-6798695; Neutrophil degranulation.
DR   Reactome; R-BTA-77387; Insulin receptor recycling.
DR   Reactome; R-BTA-917977; Transferrin endocytosis and recycling.
DR   Reactome; R-BTA-983712; Ion channel transport.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000019218; -.
DR   ExpressionAtlas; F1MH43; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:F1MH43};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    401    425       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    445    464       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    542    563       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    569    593       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    634    658       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    765    788       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   832 AA;  95659 MW;  E14D4F8AF15517E5 CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEAN FEKIENELKE INTNQEALKR
     NFLELTELKF ILRKTQQFFD EMADPDLLEE SSSLLEPSEM GRGTPLRLGF VAGVINRERI
     PTFERMLWRV CRGNVFLRQA EIENPLEDPV TGDYVHKSVF IIFFQGDQLK NRVKKICEGF
     RASLYPCPET PQERKEMASG VNTRIDDLQM VLNQTEDHRQ RVLQAAAKNI RVWFIKVRKM
     KAIYHTLNLC NIDVTQKCLI AEVWCPVTDL DSIQFALRRG TEHSGSTVPS ILNRMQTNQT
     PPTYNKTNKF TYGFQNIVDA YGIGTYREIN PAPYTIITFP FLFAVMFGDL GHGILMTLFA
     VWMVLRESRI LSQKNENEMF STIFSGRYII LLMGVFSIYT GLIYNDCFSK SLNIFGSSWS
     VRPMFDIYNW TEETLRGNPV LQLNPAVTGV FGGPYPFGID PIWNIATNKL TFLNSFKMKM
     SVILGIIHML FGVSLSLFNH TYFKKPLNIY FGFIPEIIFM TSLFGYLVIL IFYKWTAYNA
     KTSEKAPSLL IHFINMFLFS YGDSGNSMLY SGQKGIQCFL VVVALLCVPW MLLFKPLVLR
     RQYLRRKHLG TLNFGGIRVG NGPTEEDAEI IQHDQLSTHS EDAEEFDFGD TMVHQAIHTI
     EYCLGCISNT ASYLRLWALS LAHAQLSEVL WTMVIHIGLK VKSLAGGLAL FFIFAAFATL
     TVAILLIMEG LSAFLHALRL HWVEFQNKFY SGTGFKFLPF SFEHIREGKF DD
//
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