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Database: UniProt
Entry: F1MHA5_BOVIN
LinkDB: F1MHA5_BOVIN
Original site: F1MHA5_BOVIN 
ID   F1MHA5_BOVIN            Unreviewed;      4903 AA.
AC   F1MHA5;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   30-AUG-2017, entry version 52.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSBTAP00000036054};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSBTAP00000036054};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000036054, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000036054, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000036054,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000036054}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000036054};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000036054}.
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DR   EMBL; DAAA02028389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02028390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9913.ENSBTAP00000036054; -.
DR   PaxDb; F1MHA5; -.
DR   Ensembl; ENSBTAT00000036191; ENSBTAP00000036054; ENSBTAG00000025642.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; F1MHA5; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Reactome; R-BTA-2672351; Stimuli-sensing channels.
DR   Reactome; R-BTA-5578775; Ion homeostasis.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000025642; -.
DR   ExpressionAtlas; F1MHA5; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4212   4240       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4444   4464       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4512   4531       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4704   4725       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4784   4807       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        8     63       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       70    115       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      123    177       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      183    241       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      251    308       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      503    714       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      930   1126       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1270   1484       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3946   3981       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4903 AA;  555960 MW;  BC3A3B46F5B6A175 CRC64;
     QAAQGGGHRT LLYGHAILLR HSFSGMYLTC LTTSRSQTDK LAFDVGLREH ATGEACWWTI
     HPASKQRSEG EKVRIGDDLI LVSVSSERYL HLSISNGNIQ VDASFMQTLW NVHPTCSGSS
     IEEGYLLGGH VVRLFHGHDE CLTIPSTDQN DSQHRRIYYE AGGAGTRARS LWRVEPLRIS
     WSGSNIRWGQ AFRLRHLTTG HYLALTEDQG LILQDRGKSD TKSTAFSFRA SKEIKEKLDS
     SHKRDIEGMG VPEIKYGDSV CFVQHIASGL WVTYKAQDAK TSRLGPLKRK VILHQEGHMD
     DGLTLQRCQR EESQAARIIR NTTALFSQFV SGIKKFSGSY MPNNGKTAPV TLPIEEVLQT
     LHDLIAYFQP PEEGMQHEGK QNKLRSLKNR QNLFKEEGML ALVLNCIDRL NIYNSIAHFA
     GIAREESGMA WKEILNLLYK LLAALIRGNR NNCAQFSNNL DWLISKLDRL ESSSGILEVL
     HCILIESPEA LNLIAEGHIK SIISLLDKHG RNHKVLDVLC SLCLCDGVAV RANQNLICDN
     LLPRRNLLLQ TRLINDVTSI RPNIFLGVAE GSAQYKKWYF ELIIDQVDPF LTAEPTHLRV
     GWASSSGYAP YPGGGEGWGG NGVGDDLYSY GFDGLHLWSG RIPRAVASIN QHLLKSDDVV
     SCCLDLGAPS ISFRINGQPV QGMFENFNTD GLFFPVVSFS AGVKVRFLLG GRHGEFKFLP
     PSGYAPCYEA LLPKEKMRLE PVKEYKRDAE GIRDLLGTTQ FLSQASFIPC PIDTSQVVLP
     PHLEKIRDRL AENIHELWGM NKIELGWTFG KIRDDNKRQH PCLVEFSKLP ETEKNYNLQM
     STETLKTLLA LGCHIAHVNP AAEDDLKKVK LPKNYMMSNG YKPAPLDLSD VKLLPPQEVL
     VDKLAENAHN VWAKDRIKQG WTYGIQQDLK NKRNPRLVPY SLLDERTKKS NRDSLREAVR
     TFVGYGYNIE PSDQELADPA VEKVSIDKIR FFRVERSYAV RSGKWYFEFE VVTGGDMRVG
     WARPGCRPDI ELGADDQAFV FEGSRGQRWH QGSGYFGRTW QPGDVVGCMI NLDDASMIFT
     LNGELLITNK GSELAFADYE IDNGFVPICS LGLSQIGRMN LGMDASTFKF YTMCGLQEGF
     EPFAVNMNRD VAMWFSKRLP TFVNVPKDHP QIEVVRIDGT MDTPPCLKVT HKTFGTQNSS
     ATMIYCRLSM PVECHSSFSH SPCMDSDAFQ KRAEELKHGL SSPQETDNIS MASLKWGKEK
     QLKGTPVEGE RGAVKNSGQK AMLPNFFLPS PDQKKKKKNC FFIKKMMKQS LKQTVPSSPQ
     QPEEPEETHS PQLGSLTPSV VSPQQCYYAI RIFAGQDPSC VWVGWVTPDY HLYSEKFDLN
     KNCTVTVTLG DERGRVHESV KRSNCYMVWG GDIVATSQRA SRSNVDLEIG CLVDLAMGML
     SFSANGRELG TCYQVEPNTK VFPAVFLQPT STSLFQFELG KLKNAMPLSA AIFKSEEKNP
     VPQCPPRLDV QTIQPVLWSR MPSSFLKVET ERVSERHGWV VQCLEPLQMM ALHIPEENRC
     VDILELCEQE DLMRFHYHTL RLYSALCALG NSRVAYALCS HVDLSQLFYA IDNKYLPGLL
     RSGFYDLLIS IHLASAKERK LMMKNEYIIP ITSTTRKIRL YPDESKRHGL PGVGPRTCLK
     PGFRFSTPCF ITTNEEHQKQ SPEIPLELLK TKALGMLTEA VQCSGAHIRD PVGGSVEFQF
     VPVLKLIGTL LIMGVFDDDD VRQILLLIDP SVFGEHSGET EEGAEKEEVT QVEEKAVEAG
     EKASREAPIK GLLQTRLPES VKLQMCELLS YLCDCELQHR VEAIVAFGDI YVSKLQENQK
     FRYNELMQAL NMSAALTARK TREFRSPPQE QINMLLNFQL GENCPCPEEI REELYDFHED
     LLLHCGVPLE EEEEEEEDSS WTGKFCALVQ RIKGPPKPEK EQPTEEEERC PTTLKELISQ
     TMIRWAQEDQ IQDAELVRMM FNLLRRQYDS IGELLQALRK TYTISQASVS DTISLLAALG
     QIRCLLSVRM GKEEELLMIN GLGDIMNNKV FYQHPNLMRV LGMHETVMEV MVNVLGAEKL
     QIAFPKMVAS CCRFLCYFCR ISRQNQKAMF EHLSYLLENS SVGLASPSMR GSTPLDVAAS
     SVMDNNELAL GLEEPDLEKV VTYLAGCGLQ SCPMLLAKGY PDVGWNPIEG ERYLSFLRFA
     VFVNSESVEE NASVVVKLLI RRPECFGPAL RGEGGNGLLA AMQGAIKISE NPALDLPSQG
     YKREVHHFCS TEDDDDEEEI VHMGNAIMSF YSALIDLLGR CAPEMHLIQT GKGEAIRIRS
     ILRSLVPTED LVGIISIPLK LPSLNKDGSV SEPDMAANFC PDHKAPMVLF LDRVYGIKDQ
     TFLLHLLEVG FLPDLRASAS LDTVSLSTTE AALALNRYIC SAVLPLLTRC APLFAGTEHY
     TSLIDSTLQT IYRLSKGRSL TKAQRDTIEE CLLAICNHLR PSMLQQLLRR LVFDVPQLNE
     YCKMPLKLLT NHYEQCWKYY CLPSGWGSYG LAVEEELHLT EKLFWGIFDS LSHKRYDPDL
     FRMALPCLSA IAGALPPDYL DTRISATLEK QVSVDADGNF DPKPINTVNF SLPEKLEYIV
     TKYAEHSHDR WACDKSQNGW KYGISLDENV KTHPLIRPFK TLTEKEKDIY RWPARESLKT
     MLAVGWTVER TKEGEALVQQ RENEKLRSVS QASQVRPSRP KGNSYSPAPL DLSNVVLSRE
     LQGMVEVVAE NYHNIWAKKK KLELESKGGG SHPLLVPYDT LTAKEKFRDR EKAQDLFKFL
     QVNGIVVSRG MKDMELDASS MEKRFAYKFL KKVLKYVDSA QEFIAHLEAI VSSGKNEKSP
     HDQEIKFFAK VLLPLVDQYF INHRLYFLSS PLKPLSSSGY ASHKEKEMVA SLFCKLAALV
     RHRISLFGSD STTMVSCLHI LAQTLDTRTV MKSGSELVKA GLRAFFENAA EDLEKTLENL
     KLGKFTHSRT QIKGVSQNIN YTTVALLPIL TSIFEHVAQH QFGVDLLLGD VQLSCYHILC
     SLYSLGTGKN IYVERQRPAL GECLASLAAA IPVAFLEPTL NRYNPLSVFN TKTPRERSIL
     GMPDTVEEMC PDIPQLEGLM KEINDLAESG ARYTEMPHVI EVILPMLCNY LSYWWERGPE
     HLPPSAGPWC TKVTSEHLSV ILGNILKIIN NNLGIDEASW MKRIADTVYA QPIISKARPD
     LLRSHFIPTL EKLKKKAIKT VQEEEQLRAD SKGDTQEAEL LILDEFAVLC RDLYAFYPML
     IRYVDNNRSN WLKSPDADSD QLFRMVAEIF ILWCKSHNFK REEQNFVIQN EINNLAFLTG
     DSKSKMSKSG GQDQERKKTK RRGDFYSIQT SLIVAALKKM LPIGLNMCTP GDQELISLAK
     SRYSYKDTDE EVKEHLRNNL HLQEKSDDPA VKWQLNLYKD VLKSEEPSNP EKTVERVQRI
     SAAVFHLEQV EQPLRSKKAV WHKLLSKQRK RAVVACFRMA PLYNLPRHRS INLFLHGYQR
     FWIETEEYSF EEKLVQDLAK SPKVEEEEEE EVEKQPDPLH QIILHFSRNA LTERSKLEDD
     PLYTSYASMM AKSCQSGEDE DEDEDKEKTF EEKEMEKQKT LYQQARLHER GAAEMVLQMI
     SASKGEMSPM VVETLKLGIA ILNGGNAGVQ QKMLDYLKEK KDAGFFQSLS GLMQSCRSVL
     DLNAFERQNK AEGLGMVTEE GTLIVRERGE KVLQNDEFTR DLFRFLQLLC EGHNSDFQNF
     LRTQMGNTTT VNVIISTVDY LLRLQESISD FYWYYSGKDI IDESGQHNFS KALAVTKQIF
     NSLTEYIQGP CIGNQQSLAH SRLWDAVVGF LHVFANMQMK LSQDSSQIEL LKELLDLLQD
     MVVMLLSLLE GNVVNGTIGK QMVDTLVESS TNVEMILKFF DMFLKLKDLT SSDTFKEYDP
     DGKGIISKKE FQKAMEGQKQ YTQSEIDFLL SCAEADENDM FNYIDFVDRF HEPAKDIGFN
     VAVLLTNLSE HMPNDSRLKC LLDPAESVLN YFEPYLGRIE IMGGAKKIER VYFEISESSR
     TQWEKPQVKE SKRQFIFDVV NEGGEQEKME LFVNFCEDTI FEMQLASQIS ESDSADRPDE
     EEEEGGDSSY VLEVEGEEEE EEKSFECASA FAMACGSVKR NVANFLKRAT LKNLRKQYRK
     VKKMTFKELV KVFFSFFWTL FMGLFHLLFT IVGGIIQVLW STVFGGGLIE GAKNIRVTKI
     LGDMPDPTQF GIHDDAMEAE RAEVPEPGIA TELVHFVKGQ KGDADIMSDL FGLHPKKEGG
     LKHGPEVGLG DLSEIIGKDE TPTLESTVRK KRKAQVSTQA AEMKAAHEAE RKIESEKADM
     EDGEKEDTAK EEEQAEALWA DVTKRKKRRC GQKVEKPEAF MANFFKGLEI YQTKLLHYLA
     RNFYNLRFLA LFVAFAINFI LLFYKVTEEP LEEETEDVAN LWNSFNDEEE EEAVVFFVLQ
     ESTGYMAPTL RALAIIHTVI SLVCVVGYYC LKVPLVVFKR EKEIARKLEF DGLYITEQPS
     EDDIKGQWDR LVINTPSFPN NYWDKFVKRK VINKYGDLYG AERIAELLGL DKNALDFSPV
     EETKAEAASL VSWLSSIDMK YHVWKLGVVF TDNSFLYLAW YTTMSVLGHY NNFFFAAHLL
     DIAMGFKTLR TILSSVTHNG KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN KSEDDDEPDM
     KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP AGDPYEMYRI VFDITFFFFV IVILLAIIQG
     LIIDAFGELR DQQEQVREDM ETKCFICGIG NDYFDTTPHG FETHTLQEHN LANYLFFLMY
     LINKDETEHT GQESYVWKMY QERCWDFFPA GDCFRKQYED QLG
//
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