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Database: UniProt
Entry: F1MHP0_BOVIN
LinkDB: F1MHP0_BOVIN
Original site: F1MHP0_BOVIN 
ID   F1MHP0_BOVIN            Unreviewed;      2022 AA.
AC   F1MHP0;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   07-JUN-2017, entry version 50.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN5A {ECO:0000313|Ensembl:ENSBTAP00000012068};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000012068, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000012068, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000012068,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000012068}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000012068};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000012068}.
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DR   EMBL; DAAA02053650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02053651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02053652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9913.ENSBTAP00000012068; -.
DR   PaxDb; F1MHP0; -.
DR   Ensembl; ENSBTAT00000012068; ENSBTAP00000012068; ENSBTAG00000009155.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; F1MHP0; -.
DR   OMA; TWDFCCG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Reactome; R-BTA-5576892; Phase 0 - rapid depolarisation.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000009155; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    147       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    159    178       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    230    247       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    391    419       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    721    739       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    751    772       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    784    801       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    841    864       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    884    901       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    921    944       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1210   1229       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1250   1266       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1278   1299       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1327   1353       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1449   1475       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1534   1552       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1564   1586       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1598   1614       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1651   1679       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1754   1777       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      130    425       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      481    670       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      721    948       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      958   1205       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1209   1484       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1533   1787       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      416    450       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2022 AA;  228009 MW;  C2B786EEE9740445 CRC64;
     MAAFLLPRGT SSFRRFTRES LAAIEKRMAE KQARSSAASQ ESRDGLPEEE APRPQLDLQA
     SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LHVLSPFHPI
     RRVAVKILVH SLFSMLIMCT ILTNCVFMAQ HDPPPWTKYV EYIFTAIYTF ESLVKILARG
     FCLHAFTFLR DPWNWLDFSV IIMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV
     GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTVLNGT NSTNASVEAD
     GLIWASLDDY LNDPENYLLK NGTSDVLLCG NSSDAGTCPE GYRCLKAGEN PDHGYTSFDS
     FAWAFLALFR LMTQDCWERL YQQTLRSAGK IYMIFFMLVI FLGSFYLVNL ILAVVAMAYE
     EQNQATIAET EEKEKRFQEA MELLKKEQEA LAIRGVDTVS RSSLEMSPLA PVTTHERRSK
     RRKRMSSGME ECGDDKFPKS DSEDGPRAVN RFSITHGLSR TSMKPRSSHG SIFTFRRRDL
     GSETDFADDE NSTAGDSESH RTSLLVPWPL RRPSTLGQPS PGTSTPGHVL NGKRNSTVDC
     NGVVSLLGAG DPEATSPGSH LLHPMKLERP PDTTTPSEEP GRPQTLTPQA PCVDGFEEPG
     ERQRALSAVS VLTSALEELE ESQRRCPPCW IRFAQHYLIW ECCPLWMSIK QKVKFMVMDP
     FADLTITMCI VLNTLFMALE HYNMTTEFEE MLQVGNLVFT GIFTAEMTFK IIALDPYYYF
     QQGWNIFDSI IVILSLMELG LSRMGNLSVL RSFRLLRVFK LAKSWPTLNT LIKIIGNSVG
     ALGNLTLVLA IIVFIFAVVG MQLFGKNYSE QRHRISDSGL LPRWHMMDFF HAFLIIFRIL
     CGEWIETMWD CMEVSGQSLC LLVFLLVMVI GNLVVLNLFL ALLLSSFSAD NLTAPDEDGE
     MNNLQLALAR IQRGLRFIKR TTWDFCCVLL QRPPQKPTAL ASQGQLPGCI ATSSPPPQPE
     SEKAPPARKE TRFEEGQRPG QGAPGDAEPV CVPIAMAESD TDDPEEDEEN SLSTEEESSK
     QQESQPASGS PEALPEPRVW SQVSETTSSG AEASEVQADL RQQRRAEAPA PGCSELPEDS
     YSEGSTADMT NTADLLEQIP DLGEDVKDPE DCFTEGCVRR CPCCTVDTTQ AHGKVWWRLR
     KTCYRIVEHS WFETFIIFMI LLSSGALAFE DIYLEERKTI KVLLEYADKM FTYVFVLEML
     LKWVAYGFKK YFTNAWCWLD FLIVDVSLIS LVANALGFAE MGPIKSLRTL RALRPLRALS
     RFEGMRVVVN ALVGAIPSIM NVLLVCLIFW LIFSIMGVNL FAGKFGRCIN QTEGDLPLNY
     TIVNNKSDCE SFNVTGELYW TKVKVNFDNV GAGYLALLQV ATFKGWMDIM YAAVDSRGYE
     EQPQWEYNLY MYIYFVIFII FGSFFTLNLF IGVIIDNFNQ QKKKLGGQDI FMTEEQKKYY
     NAMKKLGSKK PQKPIPRPLN KYQGFIFDIV TKQAFDVTIM FLICLNMVTM MVETDDQSPE
     KVNILAKINL LFVGIFTAEC IFKMVALRHY YFTNSWNIFD FVVVILSIVG TVLSDIIQKY
     FFSPTLFRVI RLARIGRILR LIRGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYSIFG
     MANFAYVKWE AGIDDMFNFQ TFANSMLCLF QITTSAGWDG LLSPILNTGP PYCDPNLPNS
     NGSRGNCGSP AVGILFFTTY IIISFLIVVN MYIAIILENF SVATEESTEP LSEDDFDMFY
     EIWEKFDPEA TQFIEYLALS DFADALSEPL RIPKPNQISL INMDLPMVSG DRIHCMDILF
     AFTKRVLGES GEMDALKIQM EEKFMAANPS KISYEPITTT LRRKHEEVSA TIIQRAFRRH
     LLQRSVKHAS FLYRQQAGSS GLSEEDAPEQ EGLIAYMMNE NFSRRPGPPS SSSVSSTSFP
     PSYDSVTRAT SDNPQVRASD YSPSEDLADF PPTPDRDRES IV
//
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