ID F1MK69_BOVIN Unreviewed; 323 AA.
AC F1MK69;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Placental and ovary 20alpha hydroxysteroid dehydrogenase protein {ECO:0000313|Ensembl:ENSBTAP00000051595.2};
GN Name=20ALPHA-HSD {ECO:0000313|Ensembl:ENSBTAP00000051595.2};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000051595.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000051595.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000051595.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000051595.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000051595.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family.
CC {ECO:0000256|ARBA:ARBA00007905}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F1MK69; -.
DR SMR; F1MK69; -.
DR STRING; 9913.ENSBTAP00000051595; -.
DR PaxDb; 9913-ENSBTAP00000051595; -.
DR Ensembl; ENSBTAT00000056823.3; ENSBTAP00000051595.2; ENSBTAG00000037453.3.
DR VEuPathDB; HostDB:ENSBTAG00000037453; -.
DR eggNOG; KOG1577; Eukaryota.
DR GeneTree; ENSGT00940000153677; -.
DR HOGENOM; CLU_023205_0_0_1; -.
DR InParanoid; F1MK69; -.
DR OMA; HWHHRVR; -.
DR TreeFam; TF106492; -.
DR Reactome; R-BTA-193368; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
DR Reactome; R-BTA-193775; Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
DR Reactome; R-BTA-193807; Synthesis of bile acids and bile salts via 27-hydroxycholesterol.
DR Reactome; R-BTA-975634; Retinoid metabolism and transport.
DR Reactome; R-BTA-9757110; Prednisone ADME.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000037453; Expressed in surface of tongue and 18 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IBA:GO_Central.
DR GO; GO:0047023; F:androsterone dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0032052; F:bile acid binding; IBA:GO_Central.
DR GO; GO:0047086; F:ketosteroid monooxygenase activity; IBA:GO_Central.
DR GO; GO:0044597; P:daunorubicin metabolic process; IBA:GO_Central.
DR GO; GO:0044598; P:doxorubicin metabolic process; IBA:GO_Central.
DR GO; GO:0042448; P:progesterone metabolic process; IBA:GO_Central.
DR GO; GO:0006693; P:prostaglandin metabolic process; IBA:GO_Central.
DR CDD; cd19108; AKR_AKR1C1-35; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR044482; AKR1C.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732:SF533; ALDO-KETO REDUCTASE FAMILY 1 MEMBER C4; 1.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 19..300
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 55
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 117
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 84
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 323 AA; 37187 MW; 23249C92E1B4DD14 CRC64;
MDPKYQRVKL NDGHFIPILG FGTYAPEEVP KSEALEITQL AIEVGFRHID CAHLYQNERQ
VGQAIRSKIA DGTVKREDIF YTSKLWSTCL QPELVRPALE KSLKNLQLDY VDLYIIHFPL
ALKPGEELFP KDENGKIIYD SVDFCRTWEA LEKCKDAGLT KSIGVSNFNH KQLEKILNKP
GLKYKPVCNQ VECHPYLNQN KLLEFCKSHD IVLVAYGALG SQRLKNWVNP NYPILLEDPV
LCAIAKKHKQ TPALVALRYQ IQRGVVVLAK SYNRKRIKEN MQVLDFELTP EDMKAIDGLN
SNIRYYDLVF LADHPDYPFS EEY
//
