ID F1MKK1_BOVIN Unreviewed; 376 AA.
AC F1MKK1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Pregnancy-associated glycoprotein 12 {ECO:0000313|Ensembl:ENSBTAP00000025567.5};
GN Name=PAG12 {ECO:0000313|Ensembl:ENSBTAP00000025567.5};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000025567.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000025567.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000025567.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000025567.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000025567.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR AlphaFoldDB; F1MKK1; -.
DR SMR; F1MKK1; -.
DR STRING; 9913.ENSBTAP00000025567; -.
DR PaxDb; 9913-ENSBTAP00000025567; -.
DR Ensembl; ENSBTAT00000025567.5; ENSBTAP00000025567.5; ENSBTAG00000019173.5.
DR VEuPathDB; HostDB:ENSBTAG00000019173; -.
DR eggNOG; KOG1339; Eukaryota.
DR GeneTree; ENSGT00940000153747; -.
DR HOGENOM; CLU_013253_3_0_1; -.
DR InParanoid; F1MKK1; -.
DR OMA; IFHGGTE; -.
DR TreeFam; TF314990; -.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000019173; Expressed in conceptus and 3 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF49; PEPSIN A-5; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..376
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030168674"
FT DOMAIN 68..373
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 86
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 267
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 99..104
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 258..262
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 300..333
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 376 AA; 42038 MW; C836AD7CF520D55D CRC64;
MKWLVLLGLV ALSECIVILP LRKMKTLRET LREKNLLNNF LEERAYRLSK RDSKITIHPL
KNYLDMAYVG NITIGTPPQE FRVVFDTGSA DLWVPSISCV SPACYTHKTF NLHNSSSFGQ
THQPISISYG PGIIQGFLGS DTVRIGNLVS LKQSFGLSQE EYGFDGAPFD GVLGLTYPSI
SIKGIIPIFD NLWSQGAFSE PVFAFYLNTC KPEGSVVMFG GVDHRYYKGE LNWIPVSQTR
YWQISMNRIS MNGNVTACSR GCQALLDTRT SMIHGPTRLI TNIHKLMNAR HQGSEYVVSC
DAVKTLPPVI FNINGIDYPL PPQAYITKAQ NFCLSIFHGG TETSSPETWI LGGVFLRQYF
SVFDRRNDRI GLALAV
//
