ID   F1MPW4_BOVIN            Unreviewed;      1045 AA.
AC   F1MPW4;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 3.
DT   27-MAR-2024, entry version 75.
DE   RecName: Full=Structural maintenance of chromosomes protein 5 {ECO:0000256|ARBA:ARBA00018687};
GN   Name=SMC5 {ECO:0000313|Ensembl:ENSBTAP00000053371.3,
GN   ECO:0000313|VGNC:VGNC:35002};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000053371.3, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000053371.3, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053371.3,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000053371.3}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053371.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the SMC family. SMC5 subfamily.
CC       {ECO:0000256|ARBA:ARBA00010171}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; F1MPW4; -.
DR   Ensembl; ENSBTAT00000061396.3; ENSBTAP00000053371.3; ENSBTAG00000018437.7.
DR   VEuPathDB; HostDB:ENSBTAG00000018437; -.
DR   VGNC; VGNC:35002; SMC5.
DR   eggNOG; KOG0979; Eukaryota.
DR   GeneTree; ENSGT00550000074816; -.
DR   HOGENOM; CLU_004969_1_0_1; -.
DR   TreeFam; TF105708; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000018437; Expressed in thymus and 113 other cell types or tissues.
DR   ExpressionAtlas; F1MPW4; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030915; C:Smc5-Smc6 complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003395; RecF/RecN/SMC_N.
DR   InterPro; IPR027131; SMC5.
DR   PANTHER; PTHR45916; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR   PANTHER; PTHR45916:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR   Pfam; PF02463; SMC_N; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN          55..987
FT                   /note="RecF/RecN/SMC N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02463"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          238..436
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          616..723
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          854..891
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1045 AA;  122013 MW;  226B1BD97EEF034F CRC64;
     MATPSRRTST QSPLASKRAI LSDPSSEVPS KKKSSVPPAA PRPLPSSGPF VEGSIVRIAM
     ENFLTYDVCE VSPGPHLNMI IGANGTGKSS IVCAICLGLA GKPAFMGRAD KVGFFVKRGC
     SKGMVEIELF RTSGNLVITR EIDVAKNQSS WFINKKSTSP KVVEEQVAAL NIQVGNLCQF
     LPQDKVGEFA KLSKIELLEA TEKSVGPPEM HKYHCELKNF REKEKQLETS CKQKTEYLEK
     MIQRNERYKQ DVDRFYERKR HLDLIEMLEA KRPWVEYENV RQEYEEVKLA RDQAKEEVRK
     LKESQIPITE RIEEMERQRH SLEARIREKA LAIKETSQKC KHKQDVIERK DKQIEELQQA
     LTVKQNEEHD RQRRISNTRK MIEDLQNELR TTENCENLQP QIDAITNDLR RVQDEKALCE
     SEIIDKRKER ETLEKEKRSV DDHIVRFDNL MNQKEDKLRQ RYRDTYDAVL WLRNNRDKFK
     QRVCEPIMLT VRDNKKLRVN AVIAPKNSYA DKAPSRSLND LKQYGFFSYL RELFDAPDPV
     MSYLCCQYHI HEVPVGTERT REKIERVIQE TRLKQIYTAE EKYVVKTSFY SNKVISSNTS
     LKVAQFLTVT VDLEQRRHLE EQLKEINRKL QAVDSGLIAL HETNKHLEHK DNELRQKKKE
     LLERKTKKRQ LEQKISSKLG SLKLMEQDTC NLEEEERKAS TKIKEINIQK AKLVTELTNL
     IKNCTALHIQ KVDLILQNTT VISEKNKLES DYMATSAQLR ITEQHFIELD ENRQRLLQKC
     KELMKRARQV CNLGAEQTVP QEYQTQVPTI PNGHNSSPPM AFQDLPNTLD EIDALLTEER
     SRASCFTGLN PTVVEEYTKR EEEIEQLTAE LKIKKVELDK YRENISQVKE RWLNPLKELV
     EKINEKFSYF FSSMQCAGEV DLHTENEEDY DKYGIRIRVK FRSSTELHEL TPHHQSGGER
     SVSTMLYLMA LQELNRCPFR VVDEINQHSM TVCFNTSQLL QNLPYSEKMT VLFVYNGPHM
     LEPNRWNLKA FQRRRRRITF TQPSQ
//