ID F1MRT5_BOVIN Unreviewed; 514 AA.
AC F1MRT5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Docking protein 1 {ECO:0000313|Ensembl:ENSBTAP00000024727.4};
GN Name=DOK1 {ECO:0000313|Ensembl:ENSBTAP00000024727.4,
GN ECO:0000313|VGNC:VGNC:28165};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000024727.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000024727.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000024727.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000024727.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000024727.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOK family. Type A subfamily.
CC {ECO:0000256|ARBA:ARBA00010955}.
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DR AlphaFoldDB; F1MRT5; -.
DR SMR; F1MRT5; -.
DR Ensembl; ENSBTAT00000024727.4; ENSBTAP00000024727.4; ENSBTAG00000018579.5.
DR VEuPathDB; HostDB:ENSBTAG00000018579; -.
DR VGNC; VGNC:28165; DOK1.
DR GeneTree; ENSGT00940000155980; -.
DR HOGENOM; CLU_030101_3_1_1; -.
DR InParanoid; F1MRT5; -.
DR OMA; KPQGLAF; -.
DR TreeFam; TF324994; -.
DR Reactome; R-BTA-8849469; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.
DR Reactome; R-BTA-8853659; RET signaling.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000018579; Expressed in vas deferens and 104 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0038145; P:macrophage colony-stimulating factor signaling pathway; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR CDD; cd14676; PH_DOK1_2_3; 1.
DR CDD; cd01203; PTB_DOK1_DOK2_DOK3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037751; Dok1/2/3_PTB.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR21258:SF46; DOCKING PROTEIN 1; 1.
DR PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 182..290
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 514 AA; 55182 MW; 94565B19B519A284 CRC64;
MGTPPASPAP PRPAPPPGPP GQEARKEPPG AMDGAVMEGP LFLQSQRFGT KRWRKTWAVL
YPASPHGVAR LEFFDHKGSS SGGGRGSSRR LDCKVIRLAE CVSVAPVAVE SPPEPGAAAF
RLDTAQRSHL LAADAPSSAA WVQTLCQNAF PKGSWALAPA ENPPKLSALE MLENSLYSPS
WEGSQFWVTV QKTEAAERCG LHGSYVLRVE AERLTLLAPG AQRQILEPLL FWPYTLLRRY
GRDKVMFSFE AGRRCPSGPG TFTFQTAQGN DIFQAVETAI HRQKIQGKAG QGQDVLRADS
HEGEVADGKL ASLAAPLELP GSPPALYSEP LDSLRIPPGP SQDSLYSDPL DSTPARAGEG
TQLKKALYWD LCEHVQQKLI KAKLTDPKED PIYDEPEGLA PATLRGLYDL PQEPKDAWWC
QARVKEEGYE LPYNPAMDDY AVPPPRSTKP FPAPKPQGLA LSESGAATGS GSQGHSSDTA
LYSQVQKSGA SGSWDCGLSG VVTDRTGAKS EGST
//
