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Database: UniProt
Entry: F1MSJ0_BOVIN
LinkDB: F1MSJ0_BOVIN
Original site: F1MSJ0_BOVIN 
ID   F1MSJ0_BOVIN            Unreviewed;       793 AA.
AC   F1MSJ0;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   30-AUG-2017, entry version 54.
DE   SubName: Full=Two pore segment channel 1 {ECO:0000313|Ensembl:ENSBTAP00000029529};
GN   Name=TPCN1 {ECO:0000313|Ensembl:ENSBTAP00000029529};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000029529, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000029529, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000029529,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000029529}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000029529};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000029529}.
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DR   EMBL; DAAA02045423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9913.ENSBTAP00000029529; -.
DR   PaxDb; F1MSJ0; -.
DR   Ensembl; ENSBTAT00000029530; ENSBTAP00000029529; ENSBTAG00000011102.
DR   eggNOG; ENOG410INF7; Eukaryota.
DR   eggNOG; ENOG410XZT8; LUCA.
DR   GeneTree; ENSGT00530000063660; -.
DR   InParanoid; F1MSJ0; -.
DR   OMA; WLGFHTF; -.
DR   OrthoDB; EOG091G038K; -.
DR   TreeFam; TF328550; -.
DR   Reactome; R-BTA-2672351; Stimuli-sensing channels.
DR   Proteomes; UP000009136; Chromosome 17.
DR   Bgee; ENSBTAG00000011102; -.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0006816; P:calcium ion transport; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028801; TPC1.
DR   PANTHER; PTHR10037:SF262; PTHR10037:SF262; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     85    107       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    113    131       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    152    170       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    213    232       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    239    258       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    278    301       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    423    443       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    455    473       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    485    504       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    548    571       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    644    669       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      114    308       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      419    668       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   793 AA;  92117 MW;  179B46A82EC6BBFD CRC64;
     LFSQTWVVSE SPLADGGKYT VHDSQAPSLS LEGENSPSSP TEHDWEMNYQ EAAIYLQEGE
     NNDKFFTHPK NAKALAAYLF AHNHLFYLME LSAALLLLLL SLCEAPAVPA LRLGIYVHAT
     LELFALVVVV FELCMKLRWL GLHTFIRHRR TMVKTSVLVV QFVEAIVVLV RQTSHMRVTR
     ALRCIFLVDC RYCGGVRRNL RQMFQSLPPF MDILLLLLFF MIIFAILGFY LFSPNPSDPY
     FSTLENSIIS LFVLLTTANF PDVMMPSYSR NPWSCVFFIV YLSIELYFIM NLLLAVVFDT
     FNDIEKRKFK SLLLHKRTAI QHAYRLLVSQ RRPAGISYRQ FEGLMRFYKP RMSAGERYLT
     FKALNQSNTP LLSLKDFHDI YEVAALKWKA KRNREHWFDE LPRTAFLIFK GINILVKSKA
     FQYFMYLVVA VNGVWILVET FMLKGGNFVS RHVPWSHLVF LTIYAVELFL KVAGLGPIEY
     LSSGWNLFDF SVTAFAFLGL LALAFNMEPF YFIVVLRPLQ LLRLFKLKKR YRNVLDTMFE
     LLPRMASLGL TLLIFYYSFA IVGMEFFYGI LYPNCCNTST VADAYRWLNH SVGNRTVVEE
     GYYYLNNFDN ILNSFVTLFE LTVVNNWYII MEGVTSQTSH WSRLYFMTFY IVTMVVMTII
     VAFILEAFVF RMNYSRKNQD SEVDDGITLE KELSKDELVA VLKLYREAGG ANSDIAQLLK
     ILSQLERYEQ NTLVFLGRRS RTKSDLSLKM YQEEIQEWYE EHARKQEERQ LSSCVVPATQ
     QPPGSRQRSQ TIT
//
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