ID   F1MTZ1_BOVIN            Unreviewed;       353 AA.
AC   F1MTZ1;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 3.
DT   27-MAR-2024, entry version 70.
DE   RecName: Full=Protein NDRG2 {ECO:0000256|ARBA:ARBA00015427, ECO:0000256|RuleBase:RU367129};
GN   Name=NDRG2 {ECO:0000313|Ensembl:ENSBTAP00000001121.6,
GN   ECO:0000313|VGNC:VGNC:50007};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000001121.6, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000001121.6, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000001121.6,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000001121.6}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000001121.6};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Contributes to the regulation of the Wnt signaling pathway.
CC       Down-regulates CTNNB1-mediated transcriptional activation of target
CC       genes. May be involved in neuron differentiation.
CC       {ECO:0000256|RuleBase:RU367129}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU367129}.
CC   -!- SIMILARITY: Belongs to the NDRG family. {ECO:0000256|ARBA:ARBA00005598,
CC       ECO:0000256|RuleBase:RU367129}.
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DR   AlphaFoldDB; F1MTZ1; -.
DR   ESTHER; bovin-ndrg2; Ndr_family.
DR   Ensembl; ENSBTAT00000001121.6; ENSBTAP00000001121.6; ENSBTAG00000000843.6.
DR   VEuPathDB; HostDB:ENSBTAG00000000843; -.
DR   VGNC; VGNC:50007; NDRG2.
DR   GeneTree; ENSGT00950000182872; -.
DR   HOGENOM; CLU_035361_1_0_1; -.
DR   TreeFam; TF313168; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000000843; Expressed in temporal cortex and 103 other cell types or tissues.
DR   ExpressionAtlas; F1MTZ1; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR004142; NDRG.
DR   PANTHER; PTHR11034; N-MYC DOWNSTREAM REGULATED; 1.
DR   PANTHER; PTHR11034:SF17; PROTEIN NDRG2; 1.
DR   Pfam; PF03096; Ndr; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU367129};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|RuleBase:RU367129};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782,
KW   ECO:0000256|RuleBase:RU367129};
KW   Neurogenesis {ECO:0000256|ARBA:ARBA00022902,
KW   ECO:0000256|RuleBase:RU367129};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:F1MTZ1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW   ECO:0000256|RuleBase:RU367129}.
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          316..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   353 AA;  38826 MW;  3372643D4EA3D5B7 CRC64;
     MAELREVQIT EEKPLLPGQT PEVAKTHSVE TPYGSVTFTV YGTPKPKRPA ILTYHDVGLN
     YKSCFQPLFQ FADMQEIIQN FVRVHVDAPG MEEGAPVFPL GYQYPSLDQL ADMIPCILQY
     LNFSTIIGIG VGAGAYVLSR YALTHPDTVE GLVLINIDPN AKGWMDWAAH KLTGLTSSIS
     EMILGHLFSQ EELSGNSELI QKYRNIIAHA PNLDNIELYW NSYNNRRDLN FVRGGDTTLK
     CPVMLVVGDQ APHEDAVVEC NSKLDPTQTS FLKVSNPIPH SPGKLTEAFK YFLQGMGYMA
     SSCMTRLSRS RTASLTSAAS IDGNRSRSRT LSQSSESGTL SSGPPGHTME VSC
//