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Database: UniProt
Entry: F1MXA8_BOVIN
LinkDB: F1MXA8_BOVIN
Original site: F1MXA8_BOVIN 
ID   F1MXA8_BOVIN            Unreviewed;       454 AA.
AC   F1MXA8;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   30-AUG-2017, entry version 36.
DE   SubName: Full=Lipase H {ECO:0000313|Ensembl:ENSBTAP00000035908};
GN   Name=LIPH {ECO:0000313|Ensembl:ENSBTAP00000035908};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000035908, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000035908, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000035908,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000035908}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000035908};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU004262,
CC       ECO:0000256|SAAS:SAAS00591292}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000035908}.
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DR   EMBL; DAAA02001858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02001859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9913.ENSBTAP00000035908; -.
DR   PaxDb; F1MXA8; -.
DR   Ensembl; ENSBTAT00000036044; ENSBTAP00000035908; ENSBTAG00000001535.
DR   eggNOG; ENOG410IKYJ; Eukaryota.
DR   eggNOG; ENOG4111AHY; LUCA.
DR   GeneTree; ENSGT00760000119069; -.
DR   InParanoid; F1MXA8; -.
DR   OMA; SFHSAVV; -.
DR   OrthoDB; EOG091G0680; -.
DR   TreeFam; TF324997; -.
DR   Reactome; R-BTA-1483166; Synthesis of PA.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000001535; -.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR   GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR   GO; GO:0004620; F:phospholipase activity; IEA:Ensembl.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:Ensembl.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR016272; Lipase_LIPH.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00709807};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Secreted {ECO:0000256|SAAS:SAAS00439306}.
FT   DOMAIN       36    307       Lipase. {ECO:0000259|Pfam:PF00151}.
FT   ACT_SITE    154    154       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    178    178       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
FT   ACT_SITE    251    251       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR000865-1}.
SQ   SEQUENCE   454 AA;  50978 MW;  C47B71CA0540424C CRC64;
     MFKLHSTRSS LLLGTSDTDE TCPSFTKLSF HSAVVGTGLN VKLMLYTRRN PTCAQAINST
     VLGNLNVTKK TTFVVHGFRP TGSAPVWIED LVEGLLSVED MNVVIVDWNR GATTVMYNHA
     SSKTRKVATV LKEFIDLMLA EGASLDDIYI IGVSLGAHIA GFVGKMYDGQ LGRITGLDPA
     GPLFNGRPPE DRLDPRDAQF VDVIHSDTDA LGYKKQLGNI DFYPNGGLDQ PGCPQTIFGD
     NQGMQYFKCD HQRSVYLYLS SLRENCTITA YPCDSYQDYR NGKCINCGIS QTEPCPVLGY
     YADNWKDYLR EGDPPMIKAF FDTAEEKPFC IYHYFVDIIT WNKNVRRGSI TIKLKDKAGN
     TTESKINHEP ATFQKYHQVS LLARFNQDLD KVEAISLVFS TGSVIGPRYK LRILRMKLRS
     LGHPERPQLC RYDLVLMENV ETVFQPILCP KLQM
//
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