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Database: UniProt
Entry: F1MXG4_BOVIN
LinkDB: F1MXG4_BOVIN
Original site: F1MXG4_BOVIN 
ID   F1MXG4_BOVIN            Unreviewed;       740 AA.
AC   F1MXG4;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 70.
DE   RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE            EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN   Name=TMTC4 {ECO:0000313|Ensembl:ENSBTAP00000023929.4,
GN   ECO:0000313|VGNC:VGNC:36148};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000023929.4, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000023929.4, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000023929.4,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000023929.4}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000023929.4};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|ARBA:ARBA00004922}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TMTC family.
CC       {ECO:0000256|ARBA:ARBA00007882}.
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DR   RefSeq; XP_005214011.1; XM_005213954.3.
DR   AlphaFoldDB; F1MXG4; -.
DR   SMR; F1MXG4; -.
DR   PaxDb; 9913-ENSBTAP00000023929; -.
DR   Ensembl; ENSBTAT00000023929.5; ENSBTAP00000023929.4; ENSBTAG00000007066.5.
DR   VEuPathDB; HostDB:ENSBTAG00000007066; -.
DR   VGNC; VGNC:36148; TMTC4.
DR   eggNOG; KOG1124; Eukaryota.
DR   GeneTree; ENSGT00940000158521; -.
DR   HOGENOM; CLU_011615_2_0_1; -.
DR   OrthoDB; 155869at2759; -.
DR   TreeFam; TF328339; -.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000009136; Chromosome 12.
DR   Bgee; ENSBTAG00000007066; Expressed in thymus and 104 other cell types or tissues.
DR   ExpressionAtlas; F1MXG4; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR   GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
DR   GO; GO:1905584; P:outer hair cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0032470; P:positive regulation of endoplasmic reticulum calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR013618; TMTC_DUF1736.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR44227; -; 1.
DR   PANTHER; PTHR44227:SF3; PROTEIN O-MANNOSYL-TRANSFERASE TMTC4; 1.
DR   Pfam; PF08409; TMTC_DUF1736; 1.
DR   Pfam; PF13432; TPR_16; 3.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 7.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50005; TPR; 4.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        144..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        201..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        224..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        268..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        354..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        385..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        412..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        440..461
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          293..365
FT                   /note="DUF1736"
FT                   /evidence="ECO:0000259|Pfam:PF08409"
FT   REPEAT          481..514
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          515..548
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          583..616
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          685..718
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   740 AA;  83160 MW;  8224A3C01CA06B6F CRC64;
     MAEWDASLDH VIPSSLLPPF WAKFLVGFAS LMCFARSYDG DFVFDDSEAI VNNKDLRAET
     PLGDLWHHDF WGSRLSSNTS HKSYRPLTVL TFRMNYYLSG GFHPVSFHVV NIALHGGVCV
     LLVDVFSVLF GGLQYTSRGR RLNLAPRSSL LAALLFAVHP VHTECVAGVV GRADLLGALF
     FLLSFLGYCK AFRETNKEGT HSTFWVLLSI LLGAVAMLCK EQGITVLGLN AIFDILVIGK
     LNVLEIVRKL LRKDRSLESP GMLRTGGLLF RMTLLALGGA GVLYVRWKIM GTGPPVFTEV
     DNPASFADSV LVRAINYNYY YSLNAWLLLC PWWLCFDWSM GCIPLIKSVG DWRVIALAAL
     WFCLIGLICQ ALCSEDSHKR RILTLGLGFL IIPFLPASNL FFRVGFVVAE RVLYLPSAGY
     CMLLTFGFAA LSKHTKKKKL IAALILGILF LNTLRCVVRS GEWRSEDHLF RSALSVCPLN
     AKVHYNVGKN LADKGNQTAA IRYYREAVRL NPKYVHAMNN LGNILKERNE LQEAEELLSL
     AVQIQPDFAA AWMNLGIVQN SLKRFQAAEQ SYRTAIKHRR KYPDCYYNLG RLYADLNRHV
     DALNAWRNAT VLKPEHSLAW NNMIILLDNT GNLAQAEAVG REALELIPND HSLMFSLANV
     LGKSQKYKES EALFLKAIKA HPNTASYHGN LAVLYHRWGH LDLAKKHYEI SLRLDPTASG
     TKENYGLLRR KLEQMQKKNV
//
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