ID F1MXG4_BOVIN Unreviewed; 740 AA.
AC F1MXG4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN Name=TMTC4 {ECO:0000313|Ensembl:ENSBTAP00000023929.4,
GN ECO:0000313|VGNC:VGNC:36148};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000023929.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000023929.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000023929.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000023929.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000023929.4};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMTC family.
CC {ECO:0000256|ARBA:ARBA00007882}.
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DR RefSeq; XP_005214011.1; XM_005213954.3.
DR AlphaFoldDB; F1MXG4; -.
DR SMR; F1MXG4; -.
DR PaxDb; 9913-ENSBTAP00000023929; -.
DR Ensembl; ENSBTAT00000023929.5; ENSBTAP00000023929.4; ENSBTAG00000007066.5.
DR VEuPathDB; HostDB:ENSBTAG00000007066; -.
DR VGNC; VGNC:36148; TMTC4.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00940000158521; -.
DR HOGENOM; CLU_011615_2_0_1; -.
DR OrthoDB; 155869at2759; -.
DR TreeFam; TF328339; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000009136; Chromosome 12.
DR Bgee; ENSBTAG00000007066; Expressed in thymus and 104 other cell types or tissues.
DR ExpressionAtlas; F1MXG4; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
DR GO; GO:1905584; P:outer hair cell apoptotic process; IEA:Ensembl.
DR GO; GO:0032470; P:positive regulation of endoplasmic reticulum calcium ion concentration; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR013618; TMTC_DUF1736.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44227; -; 1.
DR PANTHER; PTHR44227:SF3; PROTEIN O-MANNOSYL-TRANSFERASE TMTC4; 1.
DR Pfam; PF08409; TMTC_DUF1736; 1.
DR Pfam; PF13432; TPR_16; 3.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 4.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 293..365
FT /note="DUF1736"
FT /evidence="ECO:0000259|Pfam:PF08409"
FT REPEAT 481..514
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 515..548
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 583..616
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 685..718
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 740 AA; 83160 MW; 8224A3C01CA06B6F CRC64;
MAEWDASLDH VIPSSLLPPF WAKFLVGFAS LMCFARSYDG DFVFDDSEAI VNNKDLRAET
PLGDLWHHDF WGSRLSSNTS HKSYRPLTVL TFRMNYYLSG GFHPVSFHVV NIALHGGVCV
LLVDVFSVLF GGLQYTSRGR RLNLAPRSSL LAALLFAVHP VHTECVAGVV GRADLLGALF
FLLSFLGYCK AFRETNKEGT HSTFWVLLSI LLGAVAMLCK EQGITVLGLN AIFDILVIGK
LNVLEIVRKL LRKDRSLESP GMLRTGGLLF RMTLLALGGA GVLYVRWKIM GTGPPVFTEV
DNPASFADSV LVRAINYNYY YSLNAWLLLC PWWLCFDWSM GCIPLIKSVG DWRVIALAAL
WFCLIGLICQ ALCSEDSHKR RILTLGLGFL IIPFLPASNL FFRVGFVVAE RVLYLPSAGY
CMLLTFGFAA LSKHTKKKKL IAALILGILF LNTLRCVVRS GEWRSEDHLF RSALSVCPLN
AKVHYNVGKN LADKGNQTAA IRYYREAVRL NPKYVHAMNN LGNILKERNE LQEAEELLSL
AVQIQPDFAA AWMNLGIVQN SLKRFQAAEQ SYRTAIKHRR KYPDCYYNLG RLYADLNRHV
DALNAWRNAT VLKPEHSLAW NNMIILLDNT GNLAQAEAVG REALELIPND HSLMFSLANV
LGKSQKYKES EALFLKAIKA HPNTASYHGN LAVLYHRWGH LDLAKKHYEI SLRLDPTASG
TKENYGLLRR KLEQMQKKNV
//