ID F1MZM6_BOVIN Unreviewed; 591 AA.
AC F1MZM6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Ferric chelate reductase 1 {ECO:0000313|Ensembl:ENSBTAP00000004475.5};
GN Name=FRRS1 {ECO:0000313|Ensembl:ENSBTAP00000004475.5,
GN ECO:0000313|VGNC:VGNC:112682};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000004475.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000004475.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000004475.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000004475.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000004475.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FRRS1 family.
CC {ECO:0000256|ARBA:ARBA00009195}.
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DR AlphaFoldDB; F1MZM6; -.
DR SMR; F1MZM6; -.
DR Ensembl; ENSBTAT00000004475.5; ENSBTAP00000004475.5; ENSBTAG00000003440.6.
DR VEuPathDB; HostDB:ENSBTAG00000003440; -.
DR VGNC; VGNC:112682; FRRS1.
DR GeneTree; ENSGT00940000157704; -.
DR HOGENOM; CLU_028305_2_1_1; -.
DR InParanoid; F1MZM6; -.
DR OMA; CEDVQGY; -.
DR TreeFam; TF316169; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000003440; Expressed in zone of skin and 96 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016722; F:oxidoreductase activity, acting on metal ions; IBA:GO_Central.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; IBA:GO_Central.
DR CDD; cd08760; Cyt_b561_FRRS1_like; 1.
DR CDD; cd09628; DOMON_SDR_2_like; 1.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 1.20.120.1770; -; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM.
DR InterPro; IPR005018; DOMON_domain.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR PANTHER; PTHR45828; CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE; 1.
DR PANTHER; PTHR45828:SF3; FERRIC-CHELATE REDUCTASE 1; 1.
DR Pfam; PF03351; DOMON; 1.
DR Pfam; PF02014; Reeler; 1.
DR SMART; SM00665; B561; 1.
DR SMART; SM00664; DoH; 1.
DR PROSITE; PS50939; CYTOCHROME_B561; 1.
DR PROSITE; PS50836; DOMON; 1.
DR PROSITE; PS51019; REELIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..591
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018724665"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..179
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 216..331
FT /note="DOMON"
FT /evidence="ECO:0000259|PROSITE:PS50836"
FT DOMAIN 335..533
FT /note="Cytochrome b561"
FT /evidence="ECO:0000259|PROSITE:PS50939"
SQ SEQUENCE 591 AA; 65694 MW; 86AF267875E65DB1 CRC64;
MTAPGFTVSA FILLLHVSFV ANYPSGKVTK SCGGMIPEHG HTPQSHPAHN ISVSQKTFRP
GDQIKVTLSG PPFKGFLLEA RDAENLSGPP VGSFTLIDSH VSQLLTCEDV QGSAVSHRSP
SKKTEIKVFW DAPSGAPNHI TFLATVVEKY KIYWVKIPGP VISQPNVPPF TTPEATIAPM
PTVPSVSHLT RSFNASDCGN KKFCIRSPLN CDPEKERACV FLSFTRDDQS VMVEMSGPSK
GYLSVAFSHD RWMGDDDAYV CILEDQIVHI QPSHLTGRSH PIMDFGDPLE DMAWRLVDGV
MQCSFRRNIT LPGVKNRFDL NASYYIFVAD GAAVDGRIHK HSQQPLITYE KYNVTGDPKN
IGGSHSLLLL KVHGALMFVA WMTTVSVGVL IARFFKPVWS KALFGDAAWF QVHRTLMLTT
SALTFIAFLL PFIYRGGWNW HAGYHPYLGF IVMVLAVLQL LLAAFRPPLH DPRRQMFNWT
HWSMGTAARI IAVAAMFLGM DLPGLNLPGP WKTYAMIGFV AWHVGTEIIL EIHAYRLSRK
VEILDDDRIQ ILQSFTAAEA EGYVFKKVVL AIYVCGNLTF LTMFLSAINR L
//
