ID F1N1Q7_BOVIN Unreviewed; 1653 AA.
AC F1N1Q7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 {ECO:0000313|Ensembl:ENSBTAP00000040802.4};
GN Name=PREX1 {ECO:0000313|Ensembl:ENSBTAP00000040802.4,
GN ECO:0000313|VGNC:VGNC:57017};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000040802.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000040802.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000040802.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000040802.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000040802.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; F1N1Q7; -.
DR STRING; 9913.ENSBTAP00000040802; -.
DR PaxDb; 9913-ENSBTAP00000040802; -.
DR Ensembl; ENSBTAT00000043215.4; ENSBTAP00000040802.4; ENSBTAG00000015609.6.
DR VEuPathDB; HostDB:ENSBTAG00000015609; -.
DR VGNC; VGNC:57017; PREX1.
DR eggNOG; KOG3519; Eukaryota.
DR GeneTree; ENSGT00940000159925; -.
DR HOGENOM; CLU_003935_0_0_1; -.
DR InParanoid; F1N1Q7; -.
DR OMA; TMPHYEF; -.
DR OrthoDB; 24739at2759; -.
DR TreeFam; TF328639; -.
DR Reactome; R-BTA-193648; NRAGE signals death through JNK.
DR Reactome; R-BTA-416482; G alpha (12/13) signalling events.
DR Reactome; R-BTA-8980692; RHOA GTPase cycle.
DR Reactome; R-BTA-9013106; RHOC GTPase cycle.
DR Reactome; R-BTA-9013148; CDC42 GTPase cycle.
DR Reactome; R-BTA-9013149; RAC1 GTPase cycle.
DR Reactome; R-BTA-9013404; RAC2 GTPase cycle.
DR Reactome; R-BTA-9013406; RHOQ GTPase cycle.
DR Reactome; R-BTA-9013408; RHOG GTPase cycle.
DR Reactome; R-BTA-9013409; RHOJ GTPase cycle.
DR Reactome; R-BTA-9013423; RAC3 GTPase cycle.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000015609; Expressed in neutrophil and 106 other cell types or tissues.
DR ExpressionAtlas; F1N1Q7; baseline.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
DR GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
DR GO; GO:0023051; P:regulation of signaling; IBA:GO_Central.
DR GO; GO:0030217; P:T cell differentiation; IEA:Ensembl.
DR CDD; cd04440; DEP_2_P-Rex; 1.
DR CDD; cd00136; PDZ; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF6; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN; 1.
DR Pfam; PF00610; DEP; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50186; DEP; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 47..238
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 269..390
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 419..494
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 527..595
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 623..670
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1029..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1104..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1653 AA; 185300 MW; 9863E82B2E5C44EB CRC64;
MEVSGGRDPG GDGAGDSAPP DALAHGAAAP NSGPCAAARE SERQLRLRLC VLNEILGTER
DYVGTLRFLQ SAFLHRIRQN AADSVEKGLT EENVKILFSN IEDILEVHKD FLEALEFCLH
PEPQSQHELG NVFLKFKDKF CVYEEYCSNH EKALRLLVEL NKIPAVRAFL LSCMLLGGRK
TTDIPLEGYL LSPIQRICKY PLLLKELAKR TPGKHPDHPA VQSALQAMKT VCSNINETKR
QMEKLEALEQ LQSHIEGWEG SNLTDICTQL LLQGTLLKIS AGNIQERAFF LFDNLLVYCK
RKSRVTGGKK STKRTKSING SLYIFRGRIN TEVMEVENVE DGTADYHSNG YTVTNGWKIH
NTAKNKWFVC MAKTAEEKQK WLDAIIRERE QRESLKLGME RDAYVMIAEK GEKLYHMMMS
KKVNLIKDRR RKLSTVPKCF LGNEFVAWLL EIGEISKTEE GVNLGQALLE NGIIHHVSDK
HQFKNEQVMY RFRYDDGTYK ARSELEDIMS KGVRLYCRLH SLYTPVIKDR DYHLKTYKSV
LPGSKLVDWL LAQGDCQTRE EAVALGVGLC NNGFMHHVLE KSEFKDESQY FRFHADEEME
GTSSKNKQLR NDFKLVENIL AKRLLILPQE EDYGFDIEEK NKAVVVKSVQ RGSLAEMAGL
QVGRKIFSIN EDLVFLRPLA EVESILNQSF CSRHPLRLLV ATKAKEIVKV PDHPEALCFQ
IRGAAPPYVY AVGRGSEAAA AGLCAGQCIL KVNGNNVTND GASEVLEHFQ AFRSRQEEAL
GLYQWIYRTH EDAQEAREAA GEDPSGEGAG EEDQLNSAFP LMSLGAQPSQ HEDSPLVSLT
VDNVHLEHGV VYEYVSTAGV KCHVLEKIVE PRGCFSLTAK ILEAFAADDS VFVQNCGRLM
ALSSNMRTMS HFEFRNICDT KLESIGQRIA CYQEFAAQLK SRISPPFKQA PLEPHPLCGL
DFCPTNCHVN LMEVSYPKTT PSVGRSFSIR FGRKPSLIGL DPEQGHLNPM SYTQHCITTM
AAPSWKCLPA ADGDPQRQGP NDSSFGPANG ALGQEDRGLS FLLKQEDREI QDAYLQLFTK
LDVALKEMKQ YVTQINRLLS TITEPSSSGS CDPAVAEEAS SPPLVSEESE MDRTDHGASK
KVCFKVCEED QEDSGHDTMS YRDSYSECNS NRDSVLSYTS VRSNSSYLGS DEMGSGDELP
CDMRIPSDKQ DKLHGCLEHL FNQVDSIHTL LKGPVMSRAF EETKHFPMDH SLQEFKQKEE
CTIRGRNLIQ ISIQEDPWNL PNSIKTLVDN IQRYVEDGKN QLLLALLKCT DTELQLRRDG
IFCQALVAAV CAFSEQLLAA LSYRYNNNGE YEESSRDASR KWLEQVAATG VLLHCQSLLS
PAVKEERTML EDIWVTLSEL DNVTFSFKQL DENCVANTNV FYHIEGSRQA LKVVLYLDSY
HFSKLPSRLE SGASLRLHTV LFTKALESME VSPPPGSQAV EDLQQEINAQ SLEKVQQYYR
KLRAFYLERS NLPTDASTTA VKIDQLIRPI NALDELCRLM KSLVHPKPGA AGSLGAGLIP
ISSELCYRLG ACQIAMCATG MQRSTLSLSL EQAAILARSH GLLPKCIMQA TDIMRKQGPR
VEILAKNLRV KDQVPQGAPR LYRLCQPPVD GDL
//
