ID F1N373_BOVIN Unreviewed; 386 AA.
AC F1N373;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=Pepsin A {ECO:0000256|ARBA:ARBA00039700};
DE EC=3.4.23.1 {ECO:0000256|ARBA:ARBA00011924};
GN Name=PGA5 {ECO:0000313|Ensembl:ENSBTAP00000019640.5};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000019640.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000019640.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000019640.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000019640.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000019640.5};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Shows particularly broad specificity; although bonds
CC involving phenylalanine and leucine are preferred, many others are also
CC cleaved to some extent. {ECO:0000256|ARBA:ARBA00002318}.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR RefSeq; NP_001001600.2; NM_001001600.2.
DR AlphaFoldDB; F1N373; -.
DR SMR; F1N373; -.
DR MEROPS; A01.001; -.
DR Ensembl; ENSBTAT00000019640.6; ENSBTAP00000019640.5; ENSBTAG00000014761.6.
DR GeneID; 414350; -.
DR KEGG; bta:414350; -.
DR CTD; 5222; -.
DR VEuPathDB; HostDB:ENSBTAG00000014761; -.
DR GeneTree; ENSGT00940000155036; -.
DR HOGENOM; CLU_013253_3_0_1; -.
DR InParanoid; F1N373; -.
DR OMA; ENYMDME; -.
DR OrthoDB; 1120702at2759; -.
DR TreeFam; TF314990; -.
DR Reactome; R-BTA-5683826; Surfactant metabolism.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000014761; Expressed in abomasum and 63 other cell types or tissues.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd05478; pepsin_A; 1.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR034162; Pepsin_A.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF22; PEPSIN A-3-RELATED; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Digestion {ECO:0000256|ARBA:ARBA00022757};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..386
FT /note="Pepsin A"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013084799"
FT DOMAIN 74..383
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 92
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 275
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 105..110
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 266..270
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 309..342
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 386 AA; 41557 MW; 5114491D5F282E05 CRC64;
MKWLLLLALV ALSECSVVKI PLVKKKSLRQ NLIENGKLKE FMRTHKYNLG SKYIREAATL
VSEQPLQNYL DTEYFGTIGI GTPAQDFTVI FDTGSSNLWV PSIYCSSEAC TNHNRFNPQD
SSTYEATSET LSITYGTGSM TGILGYDTVQ VGGISDTNQI FGLSETEPGS FLYYAPFDGI
LGLAYPSISS SGATPVFDNI WDQGLVSQDL FSVYLSSNEE SGSVVIFGDI DSSYYSGSLN
WVPVSVEGYW QITVDSITMN GESIACSDGC QAIVDTGTSL LAGPTTAISN IQSYIGASED
SSGEVVISCS SIDSLPDIVF TINGVQYPVP PSAYILQSNG ICSSGFEGMD ISTSSGDLWI
LGDVFIRQYF TVFDRGNNQI GLAPVA
//