ID F1N7N8_BOVIN Unreviewed; 1044 AA.
AC F1N7N8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=RAS p21 protein activator 1 {ECO:0000313|Ensembl:ENSBTAP00000012583.6};
GN Name=RASA1 {ECO:0000313|Ensembl:ENSBTAP00000012583.6,
GN ECO:0000313|VGNC:VGNC:33735};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000012583.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000012583.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000012583.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000012583.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000012583.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1N7N8; -.
DR SMR; F1N7N8; -.
DR Ensembl; ENSBTAT00000012583.6; ENSBTAP00000012583.6; ENSBTAG00000009565.6.
DR VEuPathDB; HostDB:ENSBTAG00000009565; -.
DR VGNC; VGNC:33735; RASA1.
DR GeneTree; ENSGT00940000155846; -.
DR HOGENOM; CLU_010968_1_0_1; -.
DR InParanoid; F1N7N8; -.
DR OMA; ICGCLQR; -.
DR OrthoDB; 22721at2759; -.
DR TreeFam; TF105301; -.
DR Reactome; R-BTA-186763; Downstream signal transduction.
DR Reactome; R-BTA-3928662; EPHB-mediated forward signaling.
DR Reactome; R-BTA-5218921; VEGFR2 mediated cell proliferation.
DR Reactome; R-BTA-8849471; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000009565; Expressed in spermatocyte and 110 other cell types or tissues.
DR ExpressionAtlas; F1N7N8; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051020; F:GTPase binding; IEA:Ensembl.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0048514; P:blood vessel morphogenesis; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0001953; P:negative regulation of cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:Ensembl.
DR CDD; cd08400; C2_Ras_p21A1; 1.
DR CDD; cd13260; PH_RASA1; 1.
DR CDD; cd05391; RasGAP_p120GAP; 1.
DR CDD; cd10354; SH2_Cterm_RasGAP; 1.
DR CDD; cd10353; SH2_Nterm_RasGAP; 1.
DR CDD; cd11788; SH3_RasGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR035842; RasGAP_C_SH2.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR035841; RasGAP_N_SH2.
DR InterPro; IPR035652; RasGAP_SH3.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 178..269
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 276..338
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 348..438
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 471..574
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 574..687
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 745..939
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
SQ SEQUENCE 1044 AA; 115892 MW; F9726A72FA39973A CRC64;
MMAAEAGGEE GGPVTAGAAG GGAAAASGAY PAVCRVKIPA ALPVAAAAPF PGLAEAGVAA
TLGGGAALGS GFLGPGSVAG TPGGVGLSAG GAAAGVAGVA AAAAGAGGEM AFAKGTTSLP
TETFGAGGGF PPLPPPPPQL PTLGAGLGTV DEGDSLDGPE YEEEEVAIPL TAPPTNQWYH
GKLDRTIAEE RLRQAGKSGS YLIRESDRRP GSFVLSFLSQ TNVVNHFRII AMCGDYYIGG
RRFSSLSDLI GYYSHVSCLL KGEKLLYPVA PPEPVEDRRR VRAILPYTKV PDTDEISFLK
GDMFIVHNEL EDGWMWVTNL RTDEQGLIVE DLVEEVGREE DPHEGKIWFH GKISKQEAYN
LLMTVGQVCS FLVRPSDNTP GDYSLYFRTS ENIQRFKICP TPNNQFMMGG RYYNSIGDII
DHYRKEQIVE GYYLKEPVPM QDQEQVLNDA VDGKEIYNTI RRKTKDAFYK NIVKKGYLLK
KGKGKRWKNL YFILEGSDAQ LIYFESEKRA TKPKGLIDLS VCSVYVVHDS LFGRPNCFQI
VVQHFSEEHY IFYFAGETPE QAEDWMKGLQ AFCNLRKSSP GTSNKRLRQV SSLILHIEEA
HKLPVKHFTN PYCNIYLNSV QVAKTHAREG QNPVWSEEFV FDDLPPDINR FEITLSNKTK
KSKDPDILFM RCQLSRLQKG HATDEWFLLS SHIPLKGIEP GSLRVRARYS MEKIMPEEEY
SEFKELILQK ELHVVYALSH VCGQDRTLLA SILLKIFLHE KLESLLLCTL NDREISMEDE
ATTLFRATTL ASTLMEQYMK ATATQFVHHA LKDSILRIME SKQSCELSPS KLEKNEDVNT
NLAHLLNILS ELVEKIFMAS EILPPTLRYI YGCLQKSVQH KWPTNTTMRT RVVSGFVFLR
LICPAILNPR MFNIISDSPS PIAARTLTLV AKSVQNLANL VEFGAKEPYM EGVNPFIKSN
KHRMIMFLDE LGNVPELPDT TEHSRTDLCR DLAALHEICV AHSDELRTLS NERGAQQHVL
KKLLAITELL QQKQNQYTKT NDVR
//
